Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

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A 20s complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B

1995 • 964 citations

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1995 • 940 citations

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1991 • 858 citations

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1992 • 686 citations

Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15

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Monoclonal antibodies to mitotic cells.

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1991 • 566 citations

Genes involved in sister chromatid separation are needed for b-type cyclin proteolysis in budding yeast

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1990 • 558 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

Microtubule nucleation by γ-tubulin-containing rings in the centrosome

1995 • 530 citations

Purification and Molecular Cloning of Plx1, a Cdc25-Regulatory Kinase from Xenopus Egg Extracts

1996 • 506 citations

CDC25 Phosphatases as Potential Human Oncogenes

1995 • 498 citations

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

1995 • 471 citations

In vitro reconstitution of centrosome assembly and function: The central role of γ-tubulin

1994 • 457 citations

γ-Tubulin is a centrosomal protein required for cell cycle-dependent microtubule nucleation

1992 • 447 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

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γ-Tubulin is present in Drosophila melanogaster and homo sapiens and is associated with the centrosome

1991 • 405 citations

polo encodes a protein kinase homolog required for mitosis in Drosophila.

1991 • 403 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

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p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

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CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition

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1994 • 361 citations

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The kinesin-like protein KLP61F is essential for mitosis in Drosophila.

1993 • 299 citations

Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells

1992 • 298 citations

Induction and down-regulation of PLK, a humanserine/threonine kinase expressed in proliferating cells andtumors.

1994 • 278 citations

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5

1994 • 275 citations

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

1993 • 270 citations

Plk Is an M-Phase-Specific Protein Kinase and Interacts with a Kinesin-Like Protein, CHO1/MKLP-1

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Phosphoproteins are components of mitotic microtubule organizing centers.

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1992 • 211 citations

A molecular marker for centriole maturation in the mammalian cell cycle.

1995 • 197 citations

Identification by Targeted Differential Display of an Immediate Early Gene Encoding a Putative Serine/Threonine Kinase

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Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells

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Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle.

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Identification of an Early-Growth-Response Gene Encoding a Novel Putative Protein Kinase

1992 • 187 citations

Gamma-tubulin is required for the structure and function of the microtubule organizing centre in Drosophila neuroblasts.

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1987 • 166 citations

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

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Molecular components of the centrosome

1993 • 164 citations

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.

1993 • 158 citations

Recruitment of antigenic gamma-tubulin during mitosis in animal cells: presence of gamma-tubulin in the mitotic spindle

1994 • 152 citations

The NIMA protein kinase is hyperphosphorylated and activated downstream of p34cdc2/cyclin B: coordination of two mitosis promoting kinases.

1995 • 148 citations

Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase.

1992 • 135 citations

A conserved mitotic kinase active at late anaphase—telophase in syncytial Drosophila embryos

1993 • 128 citations

Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP-4 during mitosis

1991 • 121 citations

Distribution of cytoskeletal proteins sharing a conserved phosphorylated epitope.

1986 • 118 citations

Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase.

1994 • 116 citations

Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells.

1995 • 110 citations

Nucleation of microtubules from mitotic centrosomes is modulated by a phosphorylated epitope

1990 • 108 citations

cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor.

1994 • 100 citations

Sak, a murine protein-serine/threonine kinase that is related to the Drosophila polo kinase and involved in cell proliferation.

1994 • 100 citations

Functional Components Of Microtubule-Organizing Centers

1992 • 95 citations

Cell Cycle- and Terminal Differentiation-Associated Regulation of the Mouse mRNA Encoding a Conserved Mitotic Protein Kinase

1993 • 86 citations

A Multicopy Suppressor Gene of the Saccharomyces cerevisiae G₁ Cell Cycle Mutant Gene dbf4 Encodes a Protein Kinase and Is Identified as CDC5

1993 • 84 citations

Meiosis, mitosis and microtubule motors

1993 • 72 citations

Mitotic spindle morphogenesis in animal cells.

1991 • 57 citations

The family of polo-like kinases

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1990 • 50 citations

Centrosome and cell division

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Production and characterization of monoclonal antibodies to the mammalian sperm cytoskeleton

1990 • 10 citations