A highly conserved centrosomal kinase, AIR-1, is required for accurate cell cycle progression and segregation of developmental factors in Caenorhabditis elegans embryos

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.

1991 • 3,108 citations

[22] Using CLUSTAL for multiple sequence alignments

1996 • 1,594 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo

1995 • 940 citations

MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 • 836 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

1997 • 663 citations

Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules

1996 • 651 citations

XKCM1: A Xenopus Kinesin-Related Protein That Regulates Microtubule Dynamics during Mitotic Spindle Assembly

1996 • 539 citations

Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos

1983 • 534 citations

Regulation of microtubule dynamics by cdc2 protein kinase in cell-free extracts of Xenopus eggs

1990 • 446 citations

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

1995 • 407 citations

At the heart of the budding yeast cell cycle

1996 • 367 citations

Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans.

1987 • 346 citations

Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegans

1994 • 340 citations

Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster

1997 • 318 citations

pop-1 Encodes an HMG box protein required for the specification of a mesoderm precursor in Early C. elegans embryos

1995 • 314 citations

Formation of the first cleavage spindle in nematode embryos

1984 • 307 citations

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

1993 • 301 citations

One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis

1990 • 291 citations

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

Type 1 protein phosphatase acts in opposition to IpL1 protein kinase in regulating yeast chromosome segregation.

1994 • 271 citations

Cell Cycle-dependent Expression and Spindle Pole Localization of a Novel Human Protein Kinase, Aik, Related to Aurora of Drosophila and Yeast Ipl1

1997 • 265 citations

A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans

1996 • 262 citations

MEX-3 Is a KH Domain Protein That Regulates Blastomere Identity in Early C. elegans Embryos

1996 • 260 citations

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos

1996 • 254 citations

Centrosome movement in the early divisions of Caenorhabditis elegans: a cortical site determining centrosome position.

1989 • 250 citations

Multiple potential germ-line helicases are components of the germ-line-specific P granules of Caenorhabditis elegans

1996 • 241 citations

The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos

1992 • 240 citations

Coupling cell division and cell death to microtubule dynamics

1997 • 228 citations

The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase

1993 • 215 citations

Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis

1997 • 191 citations

The dissociation of nuclear and centrosomal division in gnu, a mutation causing giant nuclei in Drosophila

1986 • 186 citations

Trans-splicing and polycistronic transcription in Caenohabditis elegans

1995 • 181 citations

Going mobile: microtubule motors and chromosome segregation.

1996 • 175 citations

ZYG-9, A Caenorhabditis elegans Protein Required for Microtubule Organization and Function, Is a Component of Meiotic and Mitotic Spindle Poles

1998 • 173 citations

Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisation

1996 • 156 citations

Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo

1996 • 149 citations

The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule component

1997 • 142 citations

A Novel Mammalian, Mitotic Spindle–associated Kinase Is Related to Yeast and Fly Chromosome Segregation Regulators

1997 • 138 citations

Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase.

1992 • 135 citations

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.

1995 • 134 citations

An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes

1988 • 131 citations

Onset ofC. elegansGastrulation Is Blocked by Inhibition of Embryonic Transcription with an RNA Polymerase Antisense RNA

1996 • 117 citations

Genetic Requirements for PIE-1 Localization and Inhibition of Gene Expression in the Embryonic Germ Lineage ofCaenorhabditis elegans

1998 • 102 citations

Dynamic Changes in Nuclear Architecture during Mitosis: On the Role of Protein Phosphorylation in Spindle Assembly and Chromosome Segregation

1996 • 94 citations

Deficiency of protein phosphatase 2A uncouples the nuclear and centrosome cycles and prevents attachment of microtubules to the kinetochore in Drosophila microtubule star (mts) embryos

1996 • 92 citations

Anaphase onset and dephosphorylation of mitotic phosphoproteins occur concomitantly

1989 • 92 citations

par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.

1994 • 87 citations

Mitotic spindle morphogenesis in animal cells.

1991 • 57 citations

Cortical domains and the mechanisms of asymmetric cell division

1996 • 49 citations

Abnormal anaphase resolution (aar): a locus required for progression through mitosis in Drosophila

1993 • 43 citations

Cell polarity: Par for the polar course

1997 • 20 citations

Odd chromosome movement and inaccurate chromosome distribution in mitosis and meiosis after treatment with protein kinase inhibitors

1993 • 18 citations

Odd chromosome movement and inaccurate chromosome distribution in mitosis and meiosis after treatment with protein kinase inhibitors

1993 • 17 citations