Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Mitotic Phosphorylation of Histone H3 Is Governed by Ipl1/aurora Kinase and Glc7/PP1 Phosphatase in Budding Yeast and Nematodes

2000 • 847 citations

Phosphorylation of Histone H3 Is Required for Proper Chromosome Condensation and Segregation

1999 • 701 citations

Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

2002 • 651 citations

Drosophila Aurora B Kinase Is Required for Histone H3 Phosphorylation and Condensin Recruitment during Chromosome Condensation and to Organize the Central Spindle during Cytokinesis

2001 • 616 citations

AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

2003 • 615 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53

2003 • 570 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

Aurora B Regulates MCAK at the Mitotic Centromere

2004 • 527 citations

Characterization of the p53-Dependent Postmitotic Checkpoint following Spindle Disruption

1998 • 498 citations

Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis

2003 • 495 citations

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1997 • 483 citations

Essential Roles of Drosophila Inner Centromere Protein (Incenp) and Aurora B in Histone H3 Phosphorylation, Metaphase Chromosome Alignment, Kinetochore Disjunction, and Chromosome Segregation

2001 • 457 citations

Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity

2004 • 443 citations

Borealin

2004 • 432 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

Tetraploid State Induces p53-dependent Arrest of Nontransformed Mammalian Cells in G1

2001 • 413 citations

The Chromosomal Passenger Complex Is Required for Chromatin-Induced Microtubule Stabilization and Spindle Assembly

2004 • 412 citations

AIM-1: a mammalian midbody-associated protein required for cytokinesis

1998 • 392 citations

Phosphorylation of CPE binding factor by Eg2 regulates translation of c-mos mRNA

2000 • 373 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

A Novel Mechanism for Activation of the Protein Kinase Aurora A

2003 • 358 citations

Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

2002 • 345 citations

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

2003 • 341 citations

Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells.

1998 • 324 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases

1999 • 318 citations

Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

2003 • 318 citations

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

2001 • 317 citations

INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow

2000 • 307 citations

Aurora-A Abrogation of p53 DNA Binding and Transactivation Activity by Phosphorylation of Serine 215

2004 • 307 citations

AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos

1998 • 303 citations

Incenp and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis

2000 • 301 citations

Phosphorylation by Aurora B Converts MgcRacGAP to a RhoGAP during Cytokinesis

2003 • 298 citations

Increased mitotic phosphorylation of histone H3 attributable to AIM-1/Aurora-B overexpression contributes to chromosome number instability.

2002 • 288 citations

Centrosome Maturation and Duplication in C. elegans Require the Coiled-Coil Protein SPD-2

2004 • 274 citations

Phosphorylation of CDC25B by Aurora-A at the centrosome contributes to the G2–M transition

2004 • 265 citations

Phosphorylation of the Carboxyl Terminus of Inner Centromere Protein (INCENP) by the Aurora B Kinase Stimulates Aurora B Kinase Activity

2002 • 262 citations

Aurora‐C kinase is a novel chromosomal passenger protein that can complement Aurora‐B kinase function in mitotic cells

2004 • 262 citations

Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis

2002 • 257 citations

The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone

2000 • 252 citations

Autophosphorylation of a Newly Identified Site of Aurora-B Is Indispensable for Cytokinesis

2004 • 227 citations

On the role of aurora-A in centrosome function

2002 • 223 citations

Differentiation of Cytoplasmic and Meiotic Spindle Assembly MCAK Functions by Aurora B-dependent Phosphorylation

2004 • 220 citations

The Xenopus laevis Aurora-related Protein Kinase pEg2 Associates with and Phosphorylates the Kinesin-related Protein XlEg5

1999 • 218 citations

Aurora B Overexpression Associates with the Thyroid Carcinoma Undifferentiated Phenotype and Is Required for Thyroid Carcinoma Cell Proliferation

2005 • 202 citations

Cell cycle progression after cleavage failure

2004 • 201 citations

Aurora-B Regulates the Cleavage Furrow-specific Vimentin Phosphorylation in the Cytokinetic Process

2003 • 201 citations

DNA rereplication in the presence of mitotic spindle inhibitors in human and mouse fibroblasts lacking either p53 or pRb function.

1997 • 198 citations

BRCA1 Phosphorylation by Aurora-A in the Regulation of G2 to M Transition

2004 • 198 citations

Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle

2001 • 189 citations

Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells

2002 • 186 citations

MgcRacGAP Is Involved in Cytokinesis through Associating with Mitotic Spindle and Midbody

2001 • 183 citations

Mitotic Kinase Expression and Colorectal Cancer Progression

1999 • 177 citations

APC/Fizzy‐Related targets Aurora‐A kinase for proteolysis

2002 • 162 citations

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

2004 • 144 citations

TheS. pombeaurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation

2001 • 141 citations

S. pombe Aurora Kinase/Survivin Is Required for Chromosome Condensation and the Spindle Checkpoint Attachment Response

2003 • 140 citations

Direct Association with Inner Centromere Protein (INCENP) Activates the Novel Chromosomal Passenger Protein, Aurora-C

2004 • 140 citations

Protein Kinase Profile of Sperm and Eggs: Cloning and Characterization of Two Novel Testis-Specific Protein Kinases (AIE1, AIE2) Related to Yeast and Fly Chromosome Segregation Regulators

1998 • 135 citations

Aurora-B Phosphorylation in Vitro Identifies a Residue of Survivin That Is Essential for Its Localization and Binding to Inner Centromere Protein (INCENP) in Vivo

2004 • 130 citations

Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells

2001 • 123 citations

Survivin Enhances Aurora-B Kinase Activity and Localizes Aurora-B in Human Cells

2002 • 122 citations

Interaction of Aurora-A and centrosomin at the microtubule-nucleating site in Drosophila and mammalian cells

2003 • 118 citations

Centrosomal Kinases, HsAIRK1 and HsAIRK3, are Overexpressed in Primary Colorectal Cancers

2000 • 114 citations

Evolutionary relationships of Aurora kinases: implications for model organism studies and the development of anti-cancer drugs.

2004 • 114 citations

CPEB phosphorylation and cytoplasmic polyadenylation are catalyzed by the kinase IAK1/Eg2 in maturing mouse oocytes

2001 • 114 citations

Degradation of human Aurora‐A protein kinase is mediated by hCdh1

2002 • 104 citations

Overexpression of Aurora-A potentiates HRAS-mediated oncogenic transformation and is implicated in oral carcinogenesis

2004 • 103 citations

Cloning of STK13, a Third Human Protein Kinase Related toDrosophilaAurora and Budding Yeast Ipl1 That Maps on Chromosome 19q13.3–ter

1998 • 89 citations

Chromosomes take the lead in spindle assembly

1995 • 83 citations

Functional STK15 Phe31Ile Polymorphism Is Associated with the Occurrence and Advanced Disease Status of Esophageal Squamous Cell Carcinoma

2004 • 83 citations

Suppression of p160ROCK bypasses cell cycle arrest after Aurora-A/STK15 depletion

2004 • 75 citations

Identification and characterization of STK12/Aik2: a human gene related to <i>aurora</i> of Drosophila and yeast <i>IPL1</i>

1998 • 72 citations

Genomic Organization, Expression, and Chromosome Localization of a Third Aurora-Related Kinase Gene,Aie1

2000 • 68 citations

Functional Phe31Ile polymorphism in Aurora A and risk of breast carcinoma

2004 • 66 citations

The S. pombe Cdc14-like Phosphatase Clp1p Regulates Chromosome Biorientation and Interacts with Aurora Kinase

2004 • 60 citations

STK15 polymorphism and breast cancer risk in a population-based study

2004 • 57 citations

Identification of a functional destruction box in the Xenopus laevis aurora‐A kinase pEg2

2001 • 53 citations

A novel Aurora B kinase inhibitor with potent anticancer activity either as a single agent or in combination with chemotherapy

2004 • 18 citations

Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

2005 • 13 citations

A novel Aurora B kinase inhibitor with potent anticancer activity either as a single agent or in combination with chemotherapy

2004 • 7 citations