Identification and Characterization of Factors Required for Microtubule Growth and Nucleation in the Early C. elegans Embryo

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

2003 • 3,597 citations

Dynamic instability of microtubule growth

1984 • 3,187 citations

Doublecortin Is a Microtubule-Associated Protein and Is Expressed Widely by Migrating Neurons

1999 • 1,297 citations

Dynamic instability of individual microtubules analyzed by video light microscopy: rate constants and transition frequencies.

1988 • 985 citations

Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans

2005 • 903 citations

Creation of Low-Copy Integrated Transgenic Lines in Caenorhabditis elegans

2001 • 830 citations

Dynamics and mechanics of the microtubule plus end

2003 • 725 citations

Kin I Kinesins Are Microtubule-Destabilizing Enzymes

1999 • 697 citations

Aurora B Regulates MCAK at the Mitotic Centromere

2004 • 527 citations

Polarity controls forces governing asymmetric spindle positioning in the Caenorhabditis elegans embryo

2001 • 511 citations

APC binds to the novel protein EB1.

1995 • 450 citations

The Mitotic Spindle: A Self-Made Machine

2001 • 447 citations

Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts

1990 • 444 citations

Cytoplasmic Dynein Is Required for Distinct Aspects of Mtoc Positioning, Including Centrosome Separation, in the One Cell Stage Caenorhabditis elegans Embryo

1999 • 443 citations

Aurora B Phosphorylates Centromeric MCAK and Regulates Its Localization and Microtubule Depolymerization Activity

2004 • 443 citations

Functional Analysis of Kinetochore Assembly in Caenorhabditis elegans

2001 • 440 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase

2003 • 415 citations

The dynamic behavior of the APC-binding protein EB1 on the distal ends of microtubules

2000 • 401 citations

Stimulation of Microtubule Aster Formation and Spindle Assembly by the Small GTPase Ran

1999 • 393 citations

Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts

1999 • 327 citations

Microtubule plus-end-tracking proteins: mechanisms and functions

2004 • 316 citations

SAS-4 Is a C. elegans Centriolar Protein that Controls Centrosome Size

2003 • 316 citations

The C. elegans zyg-1 Gene Encodes a Regulator of Centrosome Duplication with Distinct Maternal and Paternal Roles in the Embryo

2001 • 309 citations

Centriole Assembly Requires Both Centriolar and Pericentriolar Material Proteins

2004 • 298 citations

Centrosome Maturation and Mitotic Spindle Assembly in C. elegans Require SPD-5, a Protein with Multiple Coiled-Coil Domains

2002 • 280 citations

Depletion of Centromeric MCAK Leads to Chromosome Congression and Segregation Defects Due to Improper Kinetochore Attachments

2003 • 276 citations

Centrosome Maturation and Duplication in C. elegans Require the Coiled-Coil Protein SPD-2

2004 • 274 citations

Doublecortin, a Stabilizer of Microtubules

1999 • 263 citations

The Caenorhabditis elegans Centrosomal Protein SPD-2 Is Required for both Pericentriolar Material Recruitment and Centriole Duplication

2004 • 241 citations

Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation.

1985 • 239 citations

Centrosomes direct cell polarity independently of microtubule assembly in C. elegans embryos

2004 • 221 citations

Spindle Dynamics and the Role of γ-Tubulin in EarlyCaenorhabditis elegansEmbryos

2001 • 220 citations

The kinetically dominant assembly pathway for centrosomal asters in Caenorhabditis elegans is γ-tubulin dependent

2002 • 219 citations

Reconstitution of Physiological Microtubule Dynamics Using Purified Components

2001 • 210 citations

The mechanism of spindle assembly

2004 • 206 citations

EB1–Microtubule Interactions inXenopusEgg Extracts: Role of EB1 in Microtubule Stabilization and Mechanisms of Targeting to Microtubules

2002 • 205 citations

Centrosome maturation: Measurement of microtubule nucleation throughout the cell cycle by using GFP-tagged EB1

2004 • 204 citations

WormBase: a comprehensive data resource for Caenorhabditis biology and genomics

2004 • 192 citations

MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis

2000 • 188 citations

Ran GTPase Cycle and Importins α and β Are Essential for Spindle Formation and Nuclear Envelope Assembly in LivingCaenorhabditis elegansEmbryos

2002 • 180 citations

EB1 Targets to Kinetochores with Attached, Polymerizing Microtubules

2002 • 179 citations

Chaperonin-mediated folding of vertebrate actin-related protein and gamma-tubulin

1993 • 174 citations

ZYG-9, A Caenorhabditis elegans Protein Required for Microtubule Organization and Function, Is a Component of Meiotic and Mitotic Spindle Poles

1998 • 173 citations

The Microtubule-destabilizing Kinesin XKCM1 Regulates Microtubule Dynamic Instability in Cells

2002 • 159 citations

Chapter 13 Blastomere Culture and Analysis

1995 • 151 citations

Review: Postchaperonin Tubulin Folding Cofactors and Their Role in Microtubule Dynamics

2001 • 150 citations

EB1-Microtubule Interactions in Xenopus Egg Extracts: Role of EB1 in Microtubule Stabilization and Mechanisms of Targeting to Microtubules

2002 • 141 citations

TAC-1 and ZYG-9 Form a Complex that Promotes Microtubule Assembly in C. elegans Embryos

2003 • 141 citations

Organization and Dynamics of Growing Microtubule Plus Ends during Early Mitosis

2003 • 130 citations

XMAP215: a key component of the dynamic microtubule cytoskeleton

2002 • 129 citations

An Essential Function of the C. elegans Ortholog of TPX2 Is to Localize Activated Aurora A Kinase to Mitotic Spindles

2005 • 121 citations

TAC-1, a Regulator of Microtubule Length in the C. elegans Embryo

2003 • 118 citations

The GTPase Ran Regulates Chromosome Positioning and Nuclear Envelope Assembly In Vivo

2002 • 112 citations

Caenorhabditis elegans TAC-1 and ZYG-9 Form a Complex that Is Essential for Long Astral and Spindle Microtubules

2003 • 110 citations

The forces that position a mitotic spindle asymmetrically are tethered until after the time of spindle assembly

2004 • 105 citations

The mechanism, function and regulation of depolymerizing kinesins during mitosis

2004 • 104 citations

zyg-8, a Gene Required for Spindle Positioning in C. elegans, Encodes a Doublecortin-Related Kinase that Promotes Microtubule Assembly

2001 • 100 citations

PAR Proteins Regulate Microtubule Dynamics at the Cell Cortex in C. elegans

2003 • 97 citations

Cellular Samurai: katanin and the severing of microtubules

2000 • 90 citations

High-throughput RNAi in Caenorhabditis elegans: genome-wide screens and functional genomics

2004 • 89 citations

Differential functional interplay of TOGp/XMAP215 and the KinI kinesin MCAK during interphase and mitosis

2004 • 83 citations

Microtubules don and doff their caps: dynamic attachments at plus and minus ends

2001 • 80 citations

A Spindle Checkpoint Functions during Mitosis in the EarlyCaenorhabditis elegansEmbryo

2004 • 79 citations

Centrosomal TACCtics

2002 • 70 citations

Structure of the complex between the cytosolic chaperonin CCT and phosducin-like protein

2004 • 69 citations

Genetic and Molecular Characterization of the Caenorhabditis elegans Gene, mel-26, a Postmeiotic Negative Regulator of MEI-1, a Meiotic-Specific Spindle Component

1998 • 59 citations

Metazoan Motor Models: Kinesin Superfamily inC. elegans

2002 • 52 citations

Tubulin Folding Cofactors: Half a Dozen for a Dimer

2002 • 51 citations

A Novel Step in β-Tubulin Folding Is Important for Heterodimer Formation in Saccharomyces cerevisiae

2003 • 41 citations

Doublecortin Kinase-2, a Novel Doublecortin-related Protein Kinase Associated with Terminal Segments of Axons and Dendrites

2004 • 33 citations

Microtubule Cytoskeleton: A New Twist at the End

2005 • 5 citations

Dynamics and mechanics

2000 • 3 citations