Mitotic Activation of the Kinase Aurora-A Requires Its Binding Partner Bora

Basic local alignment search tool

1990 • 87,358 citations

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Amino acid substitution matrices from protein blocks.

1992 • 5,998 citations

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

2002 • 1,749 citations

A Whole-Genome Assembly of Drosophila

2000 • 1,532 citations

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

2001 • 1,430 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

1994 • 749 citations

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

1996 • 656 citations

Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics

2000 • 632 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Ran Induces Spindle Assembly by Reversing the Inhibitory Effect of Importin α on TPX2 Activity

2001 • 592 citations

Structural Basis of Aurora-A Activation by TPX2 at the Mitotic Spindle

2003 • 591 citations

Genetic control of cell division patterns in the Drosophila embryo

1989 • 567 citations

Human TPX2 is required for targeting Aurora-A kinase to the spindle

2002 • 563 citations

The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl

2003 • 553 citations

Chromosomal passengers and the (aurora) ABCs of mitosis

2001 • 535 citations

Asymmetric segregation of Numb and Prospero during cell division

1995 • 489 citations

Dare to Be Different: Asymmetric Cell Division in Drosophila, C. elegans and Vertebrates

2004 • 444 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Borealin

2004 • 432 citations

p34cdc2 is located in both nucleus and cytoplasm; part is centrosomally associated at G2/M and enters vesicles at anaphase.

1989 • 376 citations

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts

1999 • 375 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila

1991 • 360 citations

A Novel Mechanism for Activation of the Protein Kinase Aurora A

2003 • 358 citations

The Endocytic Protein α-Adaptin Is Required for Numb-Mediated Asymmetric Cell Division in Drosophila

2002 • 355 citations

A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly

2003 • 341 citations

Aurora kinases link chromosome segregation and cell division to cancer susceptibility

2003 • 341 citations

Sequential Roles of Cdc42, Par-6, aPKC, and Lgl in the Establishment of Epithelial Polarity during Drosophila Embryogenesis

2004 • 335 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Heterotrimeric G Proteins Direct Two Modes of Asymmetric Cell Division in the Drosophila Nervous System

2001 • 314 citations

Chromosomal passengers: the four-dimensional regulation of mitotic events

2004 • 310 citations

Asymmetric Rab11 Endosomes Regulate Delta Recycling and Specify Cell Fate in the Drosophila Nervous System

2005 • 306 citations

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

1993 • 301 citations

Distinct molecular mechanism regulate cell cycle timing at successive stages of Drosophila embryogenesis.

1994 • 301 citations

Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

2005 • 268 citations

Drosophila Aurora-A Is Required for Centrosome Maturation and Actin-Dependent Asymmetric Protein Localization during Mitosis

2002 • 257 citations

Frizzled regulates localization of cell-fate determinants and mitotic spindle rotation during asymmetric cell division

2000 • 249 citations

The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome

2005 • 234 citations

The Partner of Inscuteable/Discs-Large Complex Is Required to Establish Planar Polarity during Asymmetric Cell Division in Drosophila

2001 • 230 citations

The GIT-Associated Kinase PAK Targets to the Centrosome and Regulates Aurora-A

2005 • 229 citations

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

2002 • 223 citations

Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells

2002 • 208 citations

Aurora A activates D-TACC–Msps complexes exclusively at centrosomes to stabilize centrosomal microtubules

2005 • 163 citations

The LIM Protein Ajuba Is Recruited to Cadherin-dependent Cell Junctions through an Association with α-Catenin

2003 • 151 citations

hTPX2 Is Required for Normal Spindle Morphology and Centrosome Integrity during Vertebrate Cell Division

2002 • 142 citations

Asymmetric cell division in the Drosophila nrevous system

2001 • 128 citations

Numb and α‐Adaptin regulate Sanpodo endocytosis to specify cell fate in Drosophila external sensory organs

2005 • 127 citations

The Homeotic Target Gene centrosomin Encodes an Essential Centrosomal Component

1996 • 127 citations

Regulation of Xenopus Aurora A Activation by TPX2

2004 • 126 citations

An Essential Function of the C. elegans Ortholog of TPX2 Is to Localize Activated Aurora A Kinase to Mitotic Spindles

2005 • 121 citations

Targeting of RCC1 to Chromosomes Is Required for Proper Mitotic Spindle Assembly in Human Cells

2002 • 120 citations

The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration

2005 • 112 citations

cdc2 links the Drosophila cell cycle and asymmetric division machineries

2001 • 100 citations

CSC-1

2003 • 96 citations

The N terminus of the Drosophila Numb protein directs membrane association and actin-dependent asymmetric localization

1997 • 94 citations

Asymmetric localization and function of cell-fate determinants: a fly’s view

2004 • 85 citations

Aurora A and B kinases as targets for cancer: will they be selective for tumors?

2006 • 77 citations

A genomic map of a 6-Mb region at 13q21-q22 implicated in cancer development: identification and characterization of candidate genes

2001 • 71 citations

Quantitative Analysis of Protein Dynamics during Asymmetric Cell Division

2005 • 60 citations

Cdc2-Cyclin B Triggers H3 Kinase Activation of Aurora-A in Xenopus Oocytes

2003 • 60 citations

Regulation of Aurora-A kinase on the mitotic spindle

2003 • 58 citations

Differential regulation of Cdc2 and Aurora-A in Xenopus oocytes: a crucial role of phosphatase 2A

2005 • 33 citations

Localization-Dependent and -Independent Roles of Numb Contribute to Cell-Fate Specification in Drosophila

2005 • 31 citations

Pak GITs to Aurora-A

2005 • 13 citations

TPX or Not TPX?

2005 • 12 citations