Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

Mitotic kinases as regulators of cell division and its checkpoints

2001 • 1,503 citations

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1998 • 1,288 citations

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

1998 • 1,210 citations

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

2003 • 1,175 citations

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore–microtubule attachment and in maintaining the spindle assembly checkpoint

2003 • 1,144 citations

The cellular geography of Aurora kinases

2003 • 1,118 citations

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

2004 • 944 citations

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

1995 • 822 citations

Aurora-A — A guardian of poles

2005 • 670 citations

Aurora-kinase inhibitors as anticancer agents

2004 • 658 citations

Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases

2002 • 636 citations

Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

2003 • 610 citations

Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis

2003 • 495 citations

Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

2001 • 417 citations

Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

2003 • 361 citations

Aurora‐B phosphorylates Histone H3 at serine28 with regard to the mitotic chromosome condensation

2002 • 345 citations

Aurora kinases link chromosome segregation and cell division to cancer susceptibility

2003 • 341 citations

Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules

2002 • 324 citations

Validating Aurora B as an anti-cancer drug target

2006 • 279 citations

The Xenopus protein kinase pEg2 associates with the centrosome in a cell cycle-dependent manner, binds to the spindle microtubules and is involved in bipolar mitotic spindle assembly

1998 • 240 citations

G1 tetraploidy checkpoint and the suppression of tumorigenesis

2002 • 226 citations

Identification of phosphorylated residues that affect the activity of the mitotic kinase Aurora-A

2002 • 223 citations

RNA Interference Targeting Aurora Kinase A Suppresses Tumor Growth and Enhances the Taxane Chemosensitivity in Human Pancreatic Cancer Cells

2005 • 217 citations

Roles of aurora‐A kinase in mitotic entry and G2 checkpoint in mammalian cells

2002 • 208 citations

The Kinase Activity of Aurora B Is Required for Kinetochore-Microtubule Interactions during Mitosis

2002 • 188 citations

Crosstalk of the mitotic spindle assembly checkpoint with p53 to prevent polyploidy

2004 • 159 citations

Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition

2005 • 141 citations

Aurora Kinase Inhibitor ZM447439 Blocks Chromosome-induced Spindle Assembly, the Completion of Chromosome Condensation, and the Establishment of the Spindle Integrity Checkpoint inXenopusEgg Extracts

2004 • 126 citations

Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase

2005 • 116 citations

Aurora A, mitotic entry, and spindle bipolarity

2006 • 115 citations

Activation of Aurora-A kinase by protein phosphatase inhibitor-2, a bifunctional signaling protein

2004 • 109 citations

Discovery of Novel and Potent Thiazoloquinazolines as Selective Aurora A and B Kinase Inhibitors

2006 • 90 citations

Progress in the Development of Selective Inhibitors of Aurora Kinases

2005 • 75 citations

The non-catalytic domain of the Xenopus laevis auroraA kinase localises the protein to the centrosome

2001 • 51 citations

Progress in the Development of Selective Inhibitors of Aurora Kinases

2005 • 31 citations