Aberrant Expression of Tissue‐Specific Proteins in the Thymus: A Hypothesis for the Development of Central Tolerance

‘Actively Acquired Tolerance’ of Foreign Cells

1953 • 3,103 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

1997 • 931 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.

1995 • 804 citations

Illegitimate transcription: transcription of any gene in any cell type.

1989 • 647 citations

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

1990 • 468 citations

Development and Selection of T Cells: Facts and Puzzles

1995 • 450 citations

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

1980 • 343 citations

Is CTLA-4 a master switch for peripheral T cell tolerance?

1997 • 284 citations

Thymic nurse cells—Ia-bearing epithelium involved in T-lymphocyte differentiation?

1980 • 269 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Towards an integrated view of thymopoiesis

1991 • 205 citations

Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues II. Concomitant and mutually exclusive synthesis of trichocytic and epithelial cytokeratins in diverse human and bovine tissues (hair follicle, nail bed and matrix, lingual papilla, thymic reticulum)

1988 • 189 citations

Thymic emigration: conveyor belts or lucky dips?

1995 • 186 citations

The Neuroendocrine Thymus: Coexistence of Oxytocin and Neurophysin in the Human Thymus

1986 • 183 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

Comparison of peptides bound to spleen and thymus class II.

1993 • 168 citations

Distinct mechanisms of extrathymic T cell tolerance due to differential expression of self antigen

1992 • 128 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

Thymic cortical epithelial cells can present self-antigens in vivo

1989 • 108 citations

Cellular and peptide requirements for in vitro clonal deletion of immature thymocytes.

1992 • 90 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

The Thymus as a Neuroendocrine Organ. Synthesis of Vasopressin and Oxytocin in Human Thymic Epithelium^a

1987 • 83 citations

Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium

1989 • 83 citations

Mechanisms of immune tolerance induction through the thymic expression of a peripheral tissue-specific protein

1995 • 74 citations

Cell surface topography of thymic microenvironments.

1988 • 69 citations

The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier?

1988 • 67 citations

Thymic nurse cells are sites of thymocyte apoptosis.

1994 • 66 citations

The neuroendocrine thymus

1988 • 63 citations

The murine thymic nurse cell: An isolated thymic microenvironment

1985 • 58 citations

Why Positive Selection?

1993 • 52 citations

Thymic nurse cells as the site of thymocyte apoptosis and apoptotic cell clearance in the thymus of cyclophosphamide-treated mice.

1996 • 52 citations

A Challenge to the Instructive Model of Positive Selection

1993 • 24 citations

Antigen presenting ability of thymic macrophages and epithelial cells: Evidence for defects in the antigen processing function of thymic epithelial cells

1991 • 20 citations

Characterization of Thymic Nurse-Cell Lymphocytes, Using an Improved Procedure for Nurse-Cell Isolation

1992 • 16 citations

Murine Thymic Nurse Cells Express ICAM‐1 on Caveolar and Vacuolar Membranes

1997 • 12 citations

Role of the thymus in natural tolerance to an autologous protein antigen.

1989 • 12 citations