Towards an integrated view of thymopoiesis

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice

1989 • 1,095 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

β2-Microglobulin deficient mice lack CD4−8+ cytolytic T cells

1990 • 997 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Positive and negative selection of an antigen receptor on T cells in transgenic mice

1988 • 758 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor

1989 • 646 citations

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

1988 • 618 citations

Death and the cell

1986 • 616 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells

1990 • 589 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia

1990 • 533 citations

Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice

1988 • 505 citations

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

1988 • 491 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Macrophage recognition of cells undergoing programmed cell death (apoptosis).

1985 • 460 citations

T Cell Selection in the Thymus

1988 • 405 citations

A novel population of T-cell receptor αβ-bearing thymocytes which predominantly expresses a single Vβ gene family

1987 • 397 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance

1990 • 380 citations

Differential expression of two distinct T-cell receptors during thymocyte development

1987 • 360 citations

Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterization

1980 • 343 citations

Self-Nonself Discrimination by T Cells

1990 • 331 citations

The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1989 • 331 citations

The effect of thymus environment on T cell development and tolerance

1988 • 330 citations

A Nondeletional Mechanism of Thymic Self Tolerance

1989 • 322 citations

The cell surface of mouse dendritic cells: FACS analyses of dendritic cells from different tissues including thymus

1989 • 318 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

The generation and fate of thymocytes.

1990 • 309 citations

Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

1990 • 306 citations

The Developmental Biology of T Lymphocytes

1988 • 300 citations

Role of self-peptides in positively selecting the T-cell repertoire

1990 • 300 citations

Does T-cell tolerance require a dedicated antigen-presenting cell?

1989 • 288 citations

Early events in human T cell ontogeny. Phenotypic characterization and immunohistologic localization of T cell precursors in early human fetal tissues.

1988 • 271 citations

Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage

1988 • 265 citations

Agents that elevate cAMP stimulate DNA fragmentation in thymocytes.

1990 • 265 citations

Cellular signalling in programmed cell death (apoptosis)

1990 • 255 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Characterization of murine thymocytes with CDS-associated T-cell receptor structures

1987 • 245 citations

Positive selection of the T cell repertoire: Where and when does it occur?

1989 • 242 citations

Early Events in T-Cell Maturation

1987 • 242 citations

Cell kinetics in the fetal mouse thymus: precursor cell input, proliferation, and emigration.

1987 • 230 citations

Monoclonal antibodies to stromal cell types of the mouse thymus

1984 • 228 citations

Programmed death of autoreactive thymocytes

1990 • 224 citations

Self-reactive γδ T cells are eliminated in the thymus

1990 • 221 citations

The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens

1989 • 219 citations

Expression and functional significance of the J11d marker on mouse thymocytes.

1987 • 218 citations

Thymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.

1987 • 213 citations

Developmental Status and Reconstitution Potential of Subpopulations of Murine Thymocytes

1988 • 211 citations

Compartmentalization of MHC class II gene expression in transgenic mice

1988 • 201 citations

A single stem cell can recolonize an embryonic thymus, producing phenotypically distinct T-cell populations

1985 • 199 citations

γ/δ T cells express a unique surface molecule appearing late during thymic development

1989 • 197 citations

Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment

1988 • 197 citations

T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.

1990 • 190 citations

Dynamics of Early T Cells: Prothymocyte Migration and Proliferation in the Adult Mouse Thymus

1986 • 188 citations

Antigen-induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*

1989 • 186 citations

The Human Thymic Microenvironment

1984 • 184 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

αβ lineage-specific expression of the α T cell receptor gene by nearby silencers

1989 • 182 citations

Thymic Epithelium Tolerizes for Histocompatibility Antigens

1990 • 179 citations

A novel MHC class II epitope expressed in thymic medulla but not cortex

1989 • 175 citations

Positive selection of CD4+ thymocytes controlled by MHC class II gene products

1988 • 174 citations

Deletion of self-reactive T cells before entry into the thymus medulla

1988 • 171 citations

Ontogeny of primary lymphoid organs and lymphoid stem cells

1984 • 169 citations

Differentiation potential of subsets of CD4−8− thymocytes

1987 • 169 citations

Tolerance Induced by Thymic Epithelial Grafts in Birds

1987 • 167 citations

Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development.

1986 • 167 citations

A role for clonal inactivation in T cell tolerance to Mis-1a

1990 • 166 citations

Heterogeneity of epithelial cells in the human thymus

1984 • 164 citations

Excision products of the T cell receptor gene support a progressive rearrangement model of the alpha/delta locus.

1989 • 162 citations

Ontogeny of the human thymus during fetal development

1987 • 152 citations

A cd3⁻ subset of cd4⁻8⁺ thymocytes: a rapidly cycling intermediate in the generation of cd4⁺8⁺ cells

1988 • 152 citations

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.

1989 • 151 citations

A distinct wave of human T cell receptor gamma/delta lymphocytes in the early fetal thymus: evidence for controlled gene rearrangement and cytokine production.

1990 • 148 citations

T Cell Reactivity to MHC Molecules: Immunity Versus Tolerance

1990 • 148 citations

Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny.

1990 • 148 citations

Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection

1989 • 147 citations

Positive selection determines T cell receptor V beta 14 gene usage by CD8+ T cells.

1989 • 146 citations

Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities.

1990 • 146 citations

An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen.

1987 • 145 citations

Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras.

1990 • 144 citations

NK1.1+ thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+ subset.

1990 • 141 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

The thymus has two functionally distinct populations of immature αβ+ T cells: One population is deleted by ligation of αβTCR

1989 • 140 citations

Migration and homing of lymphoid cells

1988 • 136 citations

Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities

1990 • 136 citations

Positive selection of CD4+ T cells mediated by MHC class ll-bearing stromal cell in the thymic cortex

1989 • 130 citations

Inhibition of T Cell Receptor Expression and Function in Immature CD4 ⁺ cD8 ⁺ Cells by CD4

1990 • 129 citations

Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells.

1980 • 127 citations

Unusual phenotype of B cells in the thymus of normal mice.

1988 • 127 citations

Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation.

1986 • 126 citations

In vivo thymocyte maturation. BUdR labeling of cycling thymocytes and phenotypic analysis of their progeny support the single lineage model.

1986 • 124 citations

The human thymus microenvironment: heterogeneity detected by monoclonal anti-epithelial cell antibodies.

1985 • 124 citations

Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors

1987 • 124 citations

The effects of MHC gene dosage and allelic variation on T cell receptor selection

1990 • 123 citations

Separate lineages of T cells expressing the αβ and γδ receptors

1989 • 118 citations

Strong T cell tolerance in parent----F1 bone marrow chimeras prepared with supralethal irradiation. Evidence for clonal deletion and anergy.

1990 • 112 citations

Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes

1987 • 112 citations

Seeding of thymic microenvironments defined by distinct thymocyte-stromal cell interactions is developmentally controlled.

1987 • 112 citations

Influence of the Major Histocompatibility Complex on Positive Thymic Selection of V_β17a⁺T Cells

1989 • 110 citations

T cell receptor-gamma and -delta genes preferentially utilized by adult thymocytes for the surface expression.

1989 • 110 citations

lnterleukin-2-dependent autocrine proliferation in T-cell development

1989 • 107 citations

Sequential events in thymocyte differentiation and thymus regeneration revealed by a combination of bromodeoxyuridine DNA labeling and antimitotic drug treatment.

1988 • 107 citations

Expression of antigen-specific, major histocompatibility complex-restricted receptors by cortical and medullary thymocytes in situ

1985 • 106 citations

Cell proliferation and differentiation in the fetal and early postnatal mouse thymus.

1989 • 104 citations

The phenotypic heterogeneity of mouse thymic stromal cells.

1990 • 104 citations

The selection of the α,β heterodimeric T-cell receptor for antigen

1986 • 100 citations

The Developmental Biology Of T Lymphocytes

1988 • 98 citations

Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.

1988 • 95 citations

Thymic Requirement for Clonal Deletion During T Cell Development

1989 • 95 citations

Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells.

1988 • 94 citations

Immature CD4− CD8+ murine thymocytes

1988 • 93 citations

Thymocyte LFA-1 and thymic epithelial cell ICAM-1 molecules mediate binding of activated human thymocytes to thymic epithelial cells.

1990 • 92 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

Self-tolerance to transgenic γδ T cells by intrathymic inactivation

1990 • 87 citations

Thymic cortical epithelial cells lack full capacity for antigen presentation

1989 • 85 citations

Ligand thresholds at different stages of T cell development

1990 • 84 citations

First T cell receptor alpha gene rearrangements during T cell ontogeny skew to the 5' region of the J alpha locus.

1990 • 84 citations

Monoclonal antibodies to CD2 and lymphocyte function-associated antigen 3 inhibit human thymic epithelial cell-dependent mature thymocyte activation.

1987 • 84 citations

Presentation of antigen, foreign major histocompatibility complex proteins and self by thymus cortical epithelium

1989 • 83 citations

Analysis of recent thymic emigrants with subse- and maturity-related markers

1990 • 83 citations

Early Deletion and Late Positive Selection of T-Cells Expressing a Male-Specific Receptor in T-Cell Receptor Transgenic Mice

1989 • 83 citations

Positive selection of CD4-CD8+ T cells in the thymus of normal mice

1989 • 81 citations

The function of Ia+ dendritic cells and Ia- dendritic cell precursors in thymocyte mitogenesis to lectin and lectin plus interleukin 1.

1988 • 81 citations

T cell receptor‐negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway

1990 • 79 citations

Removal of Fibroblasts from Human Epithelial Cell Cultures with Use of a Complement Fixing Monoclonal Antibody Reactive with Human Fibroblasts and Monocytes/Macrophages

1989 • 79 citations

Human intrathymic T cell differentiation.

1990 • 78 citations

CD4⁺CD8⁺ thymocytes are susceptible to DNA fragmentation induced by phorbol ester, calcium ionophore and anti‐CD3 antibody

1990 • 78 citations

The kinetics of immature murine thymocyte development in vivo

1990 • 77 citations

Blockage of αβ T-cell development by TCR γδ transgenes

1989 • 77 citations

Failure of T Cell Receptor V _β Negative Selection in an Athymic Environment

1989 • 76 citations

Development of CD4−CD8+ cytotoxic T cells requires interactions with class I MHC determinants

1988 • 76 citations

L3T4 antigen expression by hemopoietic precursor cells.

1989 • 75 citations

Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow.

1989 • 74 citations

Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance.

1989 • 72 citations

CD4+ murine T cells develop from CD8+ precursors in vivo

1987 • 71 citations

Developmental potential of CD4-8- thymocytes. Peripheral progeny include mature CD4-8- T cells bearing alpha beta T cell receptor.

1989 • 71 citations

Identification and in situ localization of the "thymic nurse cell" in man.

1983 • 70 citations

Engagement of CD4 and CD8 accessory molecules is required for T cell maturation.

1989 • 70 citations

Ontogeny of T cell receptors in the chicken thymus.

1990 • 70 citations

Cell surface topography of thymic microenvironments.

1988 • 69 citations

Surprisingly uneven distribution of the T cell receptor V beta repertoire in wild mice.

1990 • 69 citations

Thymotaxin, a Chemotactic Protein, Is Identical to β₂-Microglobulin

1989 • 68 citations

Demethylated CD8 Gene in CD4⁺T Cells Suggests that CD4⁺Cells Develop from CD8⁺Precursors

1988 • 68 citations

Positive and negative selection of T cell receptor V beta domains controlled by distinct cell populations in the thymus.

1989 • 67 citations

T‐Cell Lineages, Repertoire Selection and Tolerance Induction

1988 • 67 citations

The human thymic microenvironment. Phenotypic characterization of Hassall's bodies with the use of monoclonal antibodies.

1985 • 67 citations

The human thymic microenvironment: cortical thymic epithelium is an antigenically distinct region of the thymic microenvironment.

1984 • 67 citations

Novel post-translational regulation of TCR expression in CD4+CD8+ thymocytes influenced by CD4

1990 • 67 citations

The transcapsular route: a new way for (self-) antigens to by-pass the blood-thymus barrier?

1988 • 67 citations

Thymic epithelial antibodies: immunohistological analysis and introduction of nomenclature.

1989 • 66 citations

Expression and role of the T cell receptor in early thymocyte differentiation in vitro.

1987 • 66 citations

CD8 is required during positive selection of CD4-/CD8+ T cells.

1990 • 65 citations

Selective decreases in T cell receptor V beta expression. Decreased expression of specific V beta families is associated with expression of multiple MHC and non-MHC gene products.

1989 • 63 citations

Ligand binding to the LFA-3 cell adhesion molecule induces IL-1 production by human thymic epithelial cells.

1990 • 63 citations

Obese strain (OS) chickens with spontaneous autoimmune thyroiditis have a deficiency in thymic nurse cells.

1984 • 61 citations

Functional status of interleukin 2 receptors expressed by immature (Lyt-2-/L3T4-) thymocytes.

1986 • 60 citations

Thymocyte circular DNA excised from T cell receptor alpha-delta gene complex.

1988 • 59 citations

The murine thymic nurse cell: An isolated thymic microenvironment

1985 • 58 citations

The Development of the Human Thymus Microenviroment

1986 • 58 citations

Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation.

1990 • 58 citations

Analysis of the thymic microenvironment by monoclonal antibodies with special reference to thymic nurse cells.

1986 • 58 citations

Thymic nurse cells: possible sites of T-cell selection

1986 • 57 citations

Marked differences in the efficiency of expression of distinct alphabeta T cell receptor heterodimers

1990 • 57 citations

Heterogeneity of immature (Lyt-2-/L3T4-) thymocytes. Identification of four major phenotypically distinct subsets differing in cell cycle status and in vitro activation requirements.

1988 • 57 citations

Ontogeny of a novel CD4⁺CD8⁻CD3⁻thymocyte subpopulation: a comparison with CD4⁻ CD8⁺ CD3⁻thymocytes

1990 • 54 citations

Characterization of the subset of immature thymocytes which can undergo rapid in vitro differentiation

1989 • 54 citations

Evidence for CD8-independent T cell maturation in transgenic mice.

1990 • 53 citations

Qa-2 expression in the adult murine thymus. A unique marker for a mature thymic subset.

1989 • 53 citations

Preferential expression of fibronectin receptors on immature thymocytes.

1988 • 53 citations

Thymic ontogeny and selection of αβ and γδ T cells

1989 • 52 citations

Intra- and extrathymic B cells in physiologic and pathologic conditions

1988 • 51 citations

Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus

1990 • 51 citations

T cell differentiation within thymic nurse cells.

1986 • 51 citations

Mature T cells generated from single thymic clones are phenotypically and functionally heterogeneous.

1988 • 51 citations

T cell precursor migration towards beta 2-microglobulin is involved in thymus colonization of chicken embryos.

1990 • 51 citations

Prethymic and Intrathymic Mouse T‐Cell Progenitors. Growth Requirements and Analysis of the Expression of Genes Encoding TCR/T3 Components and other T‐Cell‐Specific Molecules

1988 • 50 citations

Intrathymic selection of murine TCRαβ⁺CD4⁻CD8⁻ thymocytes

1990 • 50 citations

Molecular, cellular, and functional properties of bone marrow T lymphocyte progenitor clones.

1987 • 50 citations

Purified lymphocyte function-associated antigen-3 (LFA-3) activates human thymocytes via the CD2 pathway.

1988 • 50 citations

The development of helper T cell precursors in mouse thymus.

1988 • 50 citations

Nuclear events after activation of CD4+8+ thymocytes.

1990 • 50 citations

The acquisition of CD4 and CD8 during the differentiation of early thymocytes in short-term culture

1989 • 50 citations

Avian thymic accessory cells.

1984 • 50 citations

Human postnatal CD4- CD8- CD3- thymic T cell precursors differentiate in vitro into T cell receptor delta-bearing cells.

1989 • 49 citations

Marked differences in the efficiency of expression of distinct alpha beta T cell receptor heterodimers.

1989 • 49 citations

IL-2 gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation.

1990 • 48 citations

Phenotype of stromal cell‐associated thymocytes in situ is compatible with selection of the T cell repertoire at an “immature” stage of thymic T cell differentiation

1987 • 48 citations

T cell specificity in twice-irradiated F1----parent bone marrow chimeras: failure to detect a role for immigrant marrow-derived cells in imprinting intrathymic H-2 restriction.

1986 • 48 citations

Thymic reticulum in mice II. Culture and characterization of nonepithelial phagocytic cells of the thymic reticulum: Their role in the syngeneic stimulation of thymic medullary lymphocytes

1983 • 47 citations

Immunohistological analysis of immigration of thymocyte-precursors into the thymus: Evidence for immigration of peripheral T cells into the thymic medulla

1989 • 47 citations

Selective expression of CD8α (Ly‐2) subunit on activated thymic γ/δ cells

1990 • 47 citations

Only dull CD3⁺ thymocytes bind to thymic epithelial cells. the binding is elicited by both CD2/LFA‐3 and LFA‐1/ICAM‐1 interactions

1989 • 46 citations

Positive selection of γδ T cells

1990 • 45 citations

Progenitor cells in the thymus: Most thymus-homing progenitor cells in the adult mouse thymus bear Pgp-1 glycoprotein but not interleukin-2 receptor on their cell surface

1986 • 44 citations

Characterization of the ligand(s) responsible for negative selection of V beta 11- and V beta 12-expressing T cells: effects of a new Mls determinant.

1990 • 44 citations

Lymphokine-mediated induction of antigen-presenting ability in thymic stromal cells.

1987 • 44 citations

Thymic epithelial cells induce in vitro differentiation of PRO-T lymphocyte clones into TCR alpha,beta/T3+ and TCR gamma,delta/T3+ cells.

1989 • 43 citations

Phenotypic characterization of murine thymic microenvironments.

1990 • 43 citations

A novel T cell-activating molecule (THAM) highly expressed on CD4-CD8- murine thymocytes.

1988 • 42 citations

Expression of T cell antigen receptor beta-chains on subsets of mouse thymocytes. Analysis by three-color flow cytometry.

1987 • 42 citations

Death and transfiguration of cortical thymocytes: a reconsideration

1990 • 42 citations

Intrathymic proliferation of perinatal mouse αβ and §γ T cell receptor-expressing mature T cells

1990 • 42 citations

The Expression of CD4 and CD8 Accessory Molecules on Mature T Cells is not Random but Correlates with the Specificity of the αβ Receptor for Antigen

1989 • 42 citations

Clonal analysis of CD4 CD8‐ human thymocytes expressing a T cell receptor γ/δ chain. Direct evidence for the de novo expression of CD8 surface antigen and of cytolytic activity against tumor targets^*

1988 • 41 citations

Thymic reticulum in mice. IV. The rosette formation between phagocytic cells of the thymic reticulum and cortical type thymocytes is mediated by complement receptor type three.

1985 • 41 citations

CD4⁻CD8⁻ thymocytes that express the T cell receptor may have previously expressed CD8

1990 • 41 citations

Interactions Between Epithelial Cells and T Lymphocytes: Role of Adhesion Molecules

1990 • 40 citations

T cell receptor expression on immature thymocytes with in vivo and in vitro precursor potential

1989 • 39 citations

Differences in turnover between thymic medullary dendritic cells and a subset of cortical macrophages.

1990 • 39 citations

Negative and positive selection of immature thymocytes: timing and the role of the ligand for alpha beta T cell receptor.

1990 • 39 citations

Molecular mechanisms for lineage commitment in T cell development.

1990 • 38 citations

Thymic stroma is required for the development of human T cell lineages in vitro

1989 • 38 citations

Thymic epithelial reticular cell subpopulations in mice defined by monoclonal antibodies.

1987 • 38 citations

The role of thymic epithelium in the acquisition of tolerance

1990 • 37 citations

Thymocyte subpopulations during early fetal development in sheep.

1986 • 37 citations

A novel CD3^‐ J11d⁺ subset of CD4⁺CD8^‐ cells repopulating thymus in radiation bone marrow chimeras

1989 • 37 citations

Development of innervation within syngeneic thymus tissue transplanted under the kidney capsule of the nude mouse: A light and ultrastructuarl microscope study

1987 • 36 citations

Control of prothymocyte proliferation by thymic accessory cells

1987 • 35 citations

In vivo dynamics of CD4^–8^– thymocytes. Proliferation, renewal and differentiation of different cell subsets studied by DNA biosynthetic labeling and surface antigen detection

1988 • 35 citations

IL-2 receptor inducibility is blocked in cortical-type thymocytes.

1988 • 35 citations

Characterization of stromal cell populations in the developing thymus of normal and nude mice

1984 • 35 citations

Parasympathetic innervation of the thymus: a histochemical and immunocytochemical study.

1986 • 34 citations

T cell differentiation in birds.

1990 • 34 citations

Identification and characterization of pro-T lymphocytes and lineage-uncommitted lymphocyte precursors from mice with three novel surface markers.

1990 • 34 citations

Ultrastructural study of macrophages in the rat thymus, with special reference to the cortico-medullary zone.

1987 • 33 citations

CD3-associated alpha/beta and gamma/delta heterodimeric receptors are expressed by distinct populations of CD4- CD8- thymocytes.

1988 • 32 citations

Heterogeneity of thymic epithelial cell (TEC) keratins--immunohistochemical and biochemical evidence for a subset of highly differentiated TEC in the mouse.

1985 • 32 citations

Ontogenic characterization of thymic B lymphocytes. Analysis in different mouse strains

1990 • 32 citations

The Role of Adhesion Molecules in Epithelial–T-Cell Interactions in Thymus and Skin

1990 • 32 citations

Mouse fetal thymus lobes cultured in IL-2 generate CD3+, TCR-gamma delta-expressing CD4-/CD8+ and CD4-/CD8- cells.

1989 • 31 citations

Identification and isolation of a T4+T8+ cell with high T3 expression in human thymus: a possible late intermediate in thymocyte differentiation.

1987 • 31 citations

Phenotype of thymic stromal cells. An immunoelectron microscopic study with anti-IA, anti-MAC-1, and anti-MAC-2 antibodies.

1988 • 31 citations

Ultrastructural studies of thymic reticulum: I. Epithelial [corrected] component.

1987 • 31 citations

Immunohistochemical characterization of rat thymic non-lymphoid cells. I. Epithelial and mesenchymal components defined by monoclonal antibodies.

1988 • 30 citations

Sympathetic innervation of fetal mouse thymus

1984 • 30 citations

Are the IL-2 Receptors Expressed in the Murine Fetal Thymus Functional?

1989 • 30 citations

Presentation of endogenous immunoglobulin determinant to immunoglobulin‐recognizing T cell clones by the thymic cells

1990 • 30 citations

Changes in inducibility of IL-2 receptor alpha-chain and T cell-receptor expression during thymocyte differentiation in the mouse.

1989 • 29 citations

Epithelial-thymocyte interactions in human thymus

1987 • 29 citations

Antibody which defines a subset of bone marrow cells that can migrate to thymus.

1989 • 29 citations

Accessory function of human thymic dendritic cells in Con A-induced proliferation of autologous thymocyte subsets.

1990 • 28 citations

Antibodies against the T cell receptor/CD3 complex interfere with distinct intra-thymic cell-cell interactionsin vivo: correlation with arrest of T cell differentiation

1989 • 28 citations

Human thymic dendritic cells. Characterization, isolation and functional assays.

1988 • 27 citations

Positive selection is an early event in thymocyte differentiation: high TCR expression by cycling immature thymocytes precedes final maturation by several days

1990 • 27 citations

In vivo treatment of neonatal mice with anti-I-A antibodies interferes with the development of the class I, class II, and Mls-reactive proliferating T cell subset.

1985 • 27 citations

Thymic nurse cells: a school for alloreactive and autoreactive cortical thymocytes?

1986 • 27 citations

Characterization of rat T cell precursors sorted by chemotactic migration toward thymotaxin

1989 • 27 citations

The Generation and Selection of the T Cell Repertoire: Insights from Studies of the Molecular Basis of T Cell Recognition

1988 • 27 citations

Molecular Indices of Functional Competence in Developing T Cells

1988 • 26 citations

Thymic stroma-derived T cell growth factor (TSTGF). I. Functional distinction of TSTGF from interleukins 2 and 4 and its preferential growth-promoting effect on helper T cell clones.

1987 • 26 citations

Characterization of lymphatic and venous emigrants from the thymus.

1990 • 26 citations

A comprehensive immunotopographic map of human thymus.

1988 • 25 citations

Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development. Evidence for positive selection.

1989 • 25 citations

Intrathymic lymphopoiesis: stromal cell-associated proliferation of T cells is independent of lymphocyte genotype.

1984 • 25 citations

Thymic selection process induced by hybrid antibodies

1988 • 25 citations

Intrathymic nurse cell lymphocytes can induce a specific graft-versus-host reaction.

1990 • 24 citations

Patterns of keratin expression in the murine thymus

1989 • 24 citations

The limited immunocompetence of thymocytes within murine thymic nurse cells

1985 • 24 citations

Analysis of thymic stromal cell subpopulations grown in vitro on extracellular matrix in defined medium. I. Growth conditions and morphology of murine thymic epithelial and mesenchymal cells.

1990 • 23 citations

Epithelial cell heterogeneity in the guinea pig thymus: Immunohistochemical characterization of four thymic epithelial subsets defined by monoclonal anti‐keratin antibodies

1986 • 22 citations

Distribution of LCA protein subspecies and the cellular adhesion molecules LFA-1, ICAM-1 and p150,95 within human foetal thymus.

1990 • 22 citations

Distribution of thymocytes expressing gamma delta receptors in the murine thymus during development.

1990 • 22 citations

Human thymic dendritic cell‐thymocyte association: ultrastructural cell phenotype analysis

1989 • 22 citations

Identification of subpopulations of mouse thymic epithelial cells in culture.

1989 • 22 citations

CD45R as a primary signal transducer stimulating IL-2 and IL-2R mRNA synthesis by CD3-4-8- thymocytes.

1989 • 22 citations

Molecular analysis of the influences of positive selection, tolerance induction, and antigen presentation on the T cell receptor repertoire.

1990 • 22 citations

Ontogeny of the rat thymus micro-environment: Development of the interdigitating cell and macrophage populations

1984 • 22 citations

The effects of interleukin 2 on early and late thymocyte differentitaion in foeatl thymus organ culture

1990 • 21 citations

Effect of interferon‐gamma and tumor necrosis factor‐alpha on lymphoepithelial interactions within thymic nurse cells

1990 • 21 citations

Immunohistology of T cell differentiation in the thymus of H‐Y‐specific T cell receptor α/β transgenic mice

1990 • 21 citations

Nature of the thymocytes associated with dendritic cells and macrophages in thymic rosettes

1989 • 20 citations

Contact-mediated maturational effects of thymic stromal cells on murine thymocytes in culture.

1989 • 20 citations

The immunobiology of gamma delta+ T cells.

1990 • 20 citations

Expression of a T cell receptor gamma-chain (V gamma 1.1J gamma 4C gamma 4) transgene in mice influences T cell receptor ontogeny and thymic architecture during development.

1990 • 20 citations

Activation of the interleukin 2 pathway precedes CD3‐T cell receptor expression in thymic development. Differential growth requirements of early and mature intrathymic subpopulations

1989 • 20 citations

Thymic nurse cells: morphological study during their isolation from murine thymus

1990 • 19 citations

Thymocytes with the predicted properties of pre-T cells.

1987 • 19 citations

Intrathymic presentation of nominal antigen by B cells

1990 • 19 citations

Macrophages phagocytose thymic lymphocytes with productively rearranged T cell receptor alpha and beta genes.

1988 • 18 citations

Sequential Analysis of the Thymocyte Differentiation in Fully Allogeneic Bone Marrow Chimera in Mice. II. Further Characterization of the CD4+ or CD8+ Single Positive Thymocytes

1990 • 18 citations

Thymic lymphoid-stromal cell complexes in mice: in vitro assay and mechanism of the complex formation.

1985 • 18 citations

The cytoarchitecture of the human thymus detected by monoclonal antibodies

1990 • 18 citations

Clonal deletion of self-reactive T cells at the early stage of T cell development in thymus of radiation bone marrow chimeras.

1990 • 18 citations

Expression of T cell receptor genes in the thymus: localization of transcripts in situ and comparison of mature and immature subsets

1990 • 18 citations

Functional responsiveness in vitro and in vivo of α/β T cell receptors expressed by the B2A2 (J11d)^– subset of CD4^–8^– thymocytes

1989 • 18 citations

IL-2-dependent proliferation of thymic accessory cells.

1988 • 17 citations

In vivo and in vitro repertoire of CD3⁺CD4−CD8–thymocytes

1990 • 17 citations

In individual T cells one productive alpha rearrangement does not appear to block rearrangement at the second allele.

1989 • 17 citations

A role for the thymic epithelium in the selection of pre-T cells from murine bone marrow.

1989 • 17 citations

Construction of chimeric thymuses in the mouse fetus by in utero surgery

1986 • 16 citations

Lymphocyte depletion in thymic nurse cells: a tool to identify in situ lympho-epithelial complexes having thymic nurse cell characteristics

1988 • 15 citations

Analysis of signal transducing mechanisms in CD3+ CD4- CD8- cells expressing the putative T cell receptor gamma gene product.

1987 • 15 citations

T cell tolerance.

1990 • 15 citations

Positive and negative selection of the T cell repertoire in MHC class II transgenic mice.

1989 • 15 citations

Heterogeneity of rat thymic epithelium defined by monoclonal anti-keratin antibodies.

1988 • 14 citations

γ/δ T cells and α/β T cells differ in their developmental patterns of receptor expression and modulation requirements

1990 • 14 citations

Phenotypic characterization of the thymus microenvironment study of the human thymus architecture.

1986 • 13 citations

Thymic epithelium in vitro

1987 • 12 citations

The myelopoietic inducing potential of mouse thymic stromal cells

1989 • 12 citations

Expression of murine IL-2 receptor beta-chain on thymic and splenic lymphocyte subpopulations as revealed by the IL-2-induced proliferative response in human IL-2 receptor alpha-chain transgenic mice.

1990 • 12 citations

The phenotype of thymocytes derived from a single clonogenic precursor.

1987 • 11 citations

Surface expression of CD4 and Thy-1 on mouse thymic stromal cells

1990 • 11 citations

Functional consequences of overexpressed Ia antigens in AK alpha/AK beta transgenic mice.

1990 • 10 citations

In situ characterization in freezefractured mouse thymuses of lymphoepithelial complexes ultrastructurally similar to isolated thymic nurse cells

1986 • 10 citations

Immunocytochemical Localization of a Medullary Thymic Epithelial Glycoprotein

1986 • 10 citations

Thymus Localization of Monoclonal Antibodies Circumventing the Blood‐Thymus Barrier

1987 • 10 citations

Thymic interdigitating reticulum cells demonstrated by immunocytochemistry.

1984 • 9 citations

Dynamics of Complex Formation between Thymocytes and Thymic Medullary Epithelial Cells

1989 • 9 citations

T cell repertoire selection during development

1989 • 9 citations

Selection of CD4+CD8+ thymocytes by complex formation with medulla-derived epithelial cells

1990 • 9 citations

Characterization of cells comprising murine thymocyte multicellular complexes.

1988 • 9 citations

Differentiation-associated cellular complex formation of murine thymocytes with thymic stromal cells.

1984 • 8 citations

T-cell development in T cell receptor alphabeta transgenic mice.

1989 • 8 citations

Clonogenic potential of murine CD4+8+ thymocytes. Direct demonstration using a V beta 6-specific proliferative stimulus in Mlsa mice.

1989 • 7 citations

Ontogeny and selection of the T cell repertoire in transgenic mice.

1989 • 7 citations

CD1+ thymocytes proliferate and give rise to functional cells after stimulation with monoclonal antibodies recognizing CD3, CD2 or CD28 surface molecules

1990 • 6 citations

Characterization of the molecules involved in thymocyte thymic epithelial cell adhesion

1988 • 3 citations

Microvasculature of the Sheep Thymus

1988 • 3 citations

Thymic accessory cells, cytokines and thymocyte activation

1990 • 3 citations

The preferential binding of immature thymocytes to a rat thymic epithelial cell line.

1989 • 2 citations

Repopulation Potential of Thymocytes Forming Rosettes with Phagocytic Cells of the Thymic Reticulum

1988 • 1 citations