Selectivity of the major histocompatibility complex class II presentation pathway of cortical thymic epithelial cell lines

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

On the thymus in the differentiation of "H-2 self-recognition" by T cells: evidence for dual recognition?

1978 • 870 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Positive Selection of Thymocytes

1995 • 604 citations

The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand

1996 • 417 citations

T Cell Selection in the Thymus

1988 • 405 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand

1989 • 386 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway

1996 • 337 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection

1996 • 331 citations

H-2 antigens of the thymus determinelymphocyte specificity

1978 • 321 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

1992 • 201 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

Endosomal aspartic proteinases are required for invariant-chain processing.

1994 • 182 citations

Invariant chain cleavage and peptide loading in major histocompatibility complex class II vesicles.

1995 • 150 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

Thymic cortical epithelial cells can present self-antigens in vivo

1989 • 108 citations

Medullary but not cortical thymic epithelial cells present soluble antigens to helper T cells.

1992 • 98 citations

CD4 T Cell Tolerance to Nuclear Proteins Induced by Medullary Thymic Epithelium

1996 • 83 citations

Chemistry and functional role of the invariant chain

1992 • 76 citations

HLA-DM: An in vivo facilitator of MHC class II peptide loading

1995 • 74 citations

Medullary thymic epithelial cells induce tolerance to intracellular proteins.

1996 • 63 citations

Proteolysis of major histocompatibility complex class II-associated invariant chain is regulated by the alternatively spliced gene product, p41.

1995 • 50 citations

Difference in antigen presentation pathways between cortical and medullary thymic epithelial cells

1996 • 47 citations

Class II-restricted presentation of a hen egg lysozyme determinant derived from endogenous antigen sequestered in the cytoplasm or endoplasmic reticulum of the antigen presenting cells.

1993 • 45 citations

Presentation of cytosolic antigen by HLA-DR requires a function encoded in the class II region of the MHC.

1993 • 35 citations

Class II MHC-restricted T cell determinants processed from either endosomes or the cytosol show similar requirements for host protein transport but different kinetics of presentation.

1991 • 32 citations