Targeting phosphoinositide 3-kinase—Moving towards therapy

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

2002 • 18,132 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

AKT/PKB Signaling: Navigating Downstream

2007 • 5,728 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Atherosclerosis

2000 • 4,558 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

2006 • 3,767 citations

Therapeutic potential of resveratrol: the in vivo evidence

2006 • 3,675 citations

Evolving concepts of rheumatoid arthritis

2003 • 3,428 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Regulation of Cell Death Protease Caspase-9 by Phosphorylation

1998 • 3,129 citations

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

2006 • 3,099 citations

Atherosclerosis

2001 • 2,982 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Defining the Role of mTOR in Cancer

2007 • 2,755 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003 • 2,136 citations

Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery

2005 • 2,090 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

2003 • 2,041 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Ras, PI(3)K and mTOR signalling controls tumour cell growth

2006 • 1,934 citations

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

2001 • 1,789 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

2002 • 1,717 citations

Pathogenesis and therapy of psoriasis

2007 • 1,652 citations

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

1994 • 1,646 citations

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 • 1,631 citations

LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade

2003 • 1,599 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

The tor pathway: a target for cancer therapy

2004 • 1,308 citations

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

2006 • 1,210 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2000 • 1,121 citations

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

2006 • 1,119 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Two Distinct Vps34 Phosphatidylinositol 3–Kinase Complexes Function in Autophagy and Carboxypeptidase Y Sorting inSaccharomyces cerevisiae

2001 • 951 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Psoriasis

2005 • 904 citations

The DNA-dependent protein kinase

1999 • 896 citations

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

2005 • 873 citations

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

1996 • 870 citations

Multiple Roles of the PI3K/PKB (Akt) Pathway in Cell Cycle Progression

2003 • 869 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

Beclin–phosphatidylinositol 3‐kinase complex functions at the trans ‐Golgi network

2001 • 786 citations

PTEN: One Gene, Many Syndromes

2003 • 774 citations

Oncogenic PI3K deregulates transcription and translation

2005 • 768 citations

The Neurobiology of Multiple Sclerosis: Genes, Inflammation, and Neurodegeneration

2006 • 750 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

PI3K in lymphocyte development, differentiation and activation

2003 • 739 citations

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1993 • 738 citations

Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis

2005 • 735 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Concentration of the Phytoalexin Resveratrol in Wine

1992 • 711 citations

Frequent inactivation of PTEN/MMAC1 in primary prostate cancer.

1997 • 698 citations

Structure, regulation and function of PKB/AKT—a major therapeutic target

2003 • 695 citations

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase.

1994 • 678 citations

The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins

1998 • 675 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Cloning and Characterization of a G Protein-Activated Human Phosphoinositide-3 Kinase

1995 • 673 citations

Structure and function of phosphoinositide 3-kinases

1998 • 666 citations

Phosphatidylinositol-3-OH kinases are Rab5 effectors

1999 • 625 citations

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

2000 • 607 citations

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

2006 • 587 citations

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

2002 • 584 citations

cell cycle and death control: long live Forkheads

2002 • 583 citations

New concepts in the immunopathogenesis of multiple sclerosis

2002 • 582 citations

Deregulated Akt3 Activity Promotes Development of Malignant Melanoma

2004 • 566 citations

PI 3-kinase p110β: a new target for antithrombotic therapy

2005 • 558 citations

Will the real Cowden syndrome please stand up: revised diagnostic criteria

2000 • 553 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

New developments in FcεRI regulation, function and inhibition

2007 • 541 citations

A Family with Severe Insulin Resistance and Diabetes Due to a Mutation in AKT2

2004 • 537 citations

Signalling through Class I PI3Ks in mammalian cells

2006 • 529 citations

PKB Binding Proteins

2002 • 528 citations

Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin.

1998 • 526 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice

2002 • 507 citations

Oncogenic PI3K and its role in cancer

2005 • 505 citations

The expanding TOR signaling network

2005 • 499 citations

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

2001 • 494 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation

2005 • 490 citations

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

2004 • 485 citations

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1999 • 478 citations

Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol.

1984 • 476 citations

mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

2007 • 473 citations

PTEN signaling pathways in melanoma

2003 • 472 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

2004 • 464 citations

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

2004 • 460 citations

Protean PTEN: Form and Function

2002 • 456 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

2006 • 449 citations

Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty

2003 • 443 citations

Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase

1999 • 442 citations

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

2002 • 440 citations

PI 3-kinase related kinases: ‘big’ players in stress-induced signaling pathways

2004 • 433 citations

Exploring the specificity of the PI3K family inhibitor LY294002

2007 • 423 citations

p110δ, a novel phosphoinositide 3-kinase in leukocytes

1997 • 417 citations

Phosphoinositide 3-kinase signalling – which way to target?

2003 • 412 citations

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

2007 • 389 citations

Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay

2001 • 388 citations

Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

2004 • 384 citations

Induction of arthritis with monoclonal antibodies to collagen.

1992 • 382 citations

Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor

2006 • 381 citations

Proteomic and functional evidence for a P2X7 receptor signalling complex

2001 • 376 citations

Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer

2005 • 367 citations

Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement

2003 • 364 citations

Phosphatidylinositol 4-kinases: old enzymes with emerging functions

2006 • 355 citations

Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex

2002 • 355 citations

Molecular genetic advances in tuberous sclerosis

2000 • 354 citations

Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases

2007 • 354 citations

Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability

2005 • 353 citations

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system.

1995 • 349 citations

Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase

2002 • 316 citations

PI3Kγ inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

2005 • 311 citations

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

2004 • 307 citations

Essential role for Gab2 in the allergic response

2001 • 306 citations

Frequent Inactivation of PTEN by Promoter Hypermethylation in Microsatellite Instability-High Sporadic Colorectal Cancers

2004 • 302 citations

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

2005 • 298 citations

Structure, function, and biology of SHIP proteins

2000 • 298 citations

Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

2002 • 293 citations

Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells

2006 • 287 citations

Forkhead transcription factors contribute to execution of the mitotic programme in mammals

2001 • 282 citations

Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis.

1984 • 278 citations

Epigenetic Silencing of the PTEN Gene in Melanoma

2006 • 271 citations

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.

1996 • 261 citations

Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.

1993 • 259 citations

Collagen arthritis as a relevant model for rheumatoid arthritis. evidence pro and con

1982 • 256 citations

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

2005 • 248 citations

Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin

1997 • 247 citations

The Class II Phosphoinositide 3-Kinase C2α Is Activated by Clathrin and Regulates Clathrin-Mediated Membrane Trafficking

2001 • 217 citations

Characterization of p150, an Adaptor Protein for the Human Phosphatidylinositol (PtdIns) 3-Kinase

1997 • 215 citations

Role of Insulin, Adipocyte Hormones, and Nutrient-Sensing Pathways in Regulating Fuel Metabolism and Energy Homeostasis: A Nutritional Perspective of Diabetes, Obesity, and Cancer

2006 • 212 citations

Wortmannin binds specifically to 1-phosphatidylinositol 3-kinase while inhibiting guanine nucleotide-binding protein-coupled receptor signaling in neutrophil leukocytes.

1994 • 212 citations

The amino acid sensitive TOR pathway from yeast to mammals

2006 • 212 citations

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

2005 • 211 citations

Characterization of Type II Phosphatidylinositol 4-Kinase Isoforms Reveals Association of the Enzymes with Endosomal Vesicular Compartments

2002 • 208 citations

Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis

2000 • 206 citations

Class I_A Phosphoinositide 3-Kinase Regulates Heart Size and Physiological Cardiac Hypertrophy

2005 • 202 citations

Wortmannin, a Widely Used Phosphoinositide 3-Kinase Inhibitor, also Potently Inhibits Mammalian Polo-like Kinase

2005 • 201 citations

Increased p85/55/50 Expression and Decreased Phosphotidylinositol 3-Kinase Activity in Insulin-Resistant Human Skeletal Muscle

2005 • 201 citations

Role of Rab5 in the Recruitment of hVps34/p150 to the Early Endosome

2002 • 200 citations

PLA2 and PI3K/PTEN Pathways Act in Parallel to Mediate Chemotaxis

2007 • 196 citations

LKB1, a protein kinase regulating cell proliferation and polarity

2003 • 191 citations

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors

2006 • 188 citations

Furan-2-ylmethylene Thiazolidinediones as Novel, Potent, and Selective Inhibitors of Phosphoinositide 3-Kinase γ

2006 • 188 citations

Collagen Autoimmune Arthritis

1984 • 181 citations

Subcellular Locations of Phosphatidylinositol 4-Kinase Isoforms

1997 • 180 citations

Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo

2000 • 178 citations

Cloning and Characterization of a Wortmannin-sensitive Human Phosphatidylinositol 4-Kinase

1997 • 171 citations

p84, a New Gβγ-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110γ

2005 • 163 citations

A Cell-permeable, Activity-based Probe for Protein and Lipid Kinases

2005 • 162 citations

Tuberous sclerosis complex: from Drosophila to human disease

2004 • 160 citations

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration

2005 • 160 citations

The 400 kDa Subunit of the PCAF Histone Acetylase Complex Belongs to the ATM Superfamily

1998 • 160 citations

Chemistry and biology of wortmannin

2005 • 159 citations

A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16

2006 • 158 citations

Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

2005 • 155 citations

Treatment of lupus with corticosteroids

2001 • 155 citations

Therapeutic Potential of Phosphatidylinositol 3-Kinase Inhibitors in Inflammatory Respiratory Disease

2006 • 155 citations

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

2007 • 154 citations

Direct Effects of Caffeine and Theophylline on p110δ and Other Phosphoinositide 3-Kinases

2002 • 151 citations

Liphagal, a Selective Inhibitor of PI3 Kinase α Isolated from the Sponge Aka coralliphaga: Structure Elucidation and Biomimetic Synthesis

2005 • 151 citations

Apoptosis, fas and systemic autoimmunity: the MRL-Ipr/Ipr model

1994 • 151 citations

Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase

2005 • 150 citations

Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ-deficient mice

2004 • 147 citations

The Class II Phosphoinositide 3-Kinase PI3K-C2α Is Concentrated in the Trans-Golgi Network and Present in Clathrin-coated Vesicles

2000 • 144 citations

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1987 • 142 citations

Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ

2005 • 141 citations

A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction

1995 • 137 citations

Selective role of PI3Kδ in neutrophil inflammatory responses

2003 • 136 citations

The Isolation and Characterization of a cDNA Encoding Phospholipid-specific Inositol Polyphosphate 5-Phosphatase

2000 • 134 citations

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

2004 • 134 citations

Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110α inhibitors

2007 • 134 citations

Platelet-derived growth factor-induced phosphatidylinositol 3-kinase activation mediates actin rearrangements in fibroblasts

1994 • 134 citations

Phosphoinositide 3-kinase γ: a key modulator in inflammation and allergy

2003 • 124 citations

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110α inhibitors

2006 • 122 citations

Lambda-Interacting Protein, A Novel Protein That Specifically Interacts with the Zinc Finger Domain of the Atypical Protein Kinase C Isotype λ/ι and Stimulates Its Kinase Activity In Vitro and In Vivo

1996 • 121 citations

Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury

2006 • 119 citations

Type ii collagen-induced arthritis Studies with Purified Anticollagen Immunoglobulin

1983 • 118 citations

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1991 • 118 citations

PTEN promoter is methylated in a proportion of invasive breast cancers

2004 • 117 citations

Studies on the Mechanism of Phosphatidylinositol 3-Kinase Inhibition by Wortmannin and Related Analogs

1996 • 116 citations

Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110α inhibitors

2007 • 115 citations

A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3‐kinase

1994 • 115 citations

Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation

2007 • 113 citations

Wortmannin, an antibiotic produced by Penicillium wortmanni

1957 • 112 citations

Genetic alterations in cervical carcinomas: Frequent low‐level amplifications of oncogenes are associated with human papillomavirus infection

2002 • 107 citations

Role of class II phosphoinositide 3-kinase in cell signalling

2007 • 106 citations

The role of SHIP in cytokine-induced signaling

2003 • 104 citations

Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8.

1995 • 103 citations

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

2007 • 102 citations

Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase γ: structure–activity analysis and interactions with wortmannin

1997 • 102 citations

IgE- and IgE+Ag-mediated mast cell migration in an autocrine/paracrine fashion

2005 • 101 citations

Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis

2007 • 100 citations

Cloning and characterization of a human phosphatidylinositol 4-kinase.

1994 • 95 citations

Cloning of a Human Type II Phosphatidylinositol 4-Kinase Reveals a Novel Lipid Kinase Family

2001 • 95 citations

Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1

2003 • 92 citations

Molecular Cloning, cDNA Sequence, and Chromosomal Localization of the Human Phosphatidylinositol 3-Kinase p110α (PIK3CA) Gene

1994 • 91 citations

The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion

2007 • 89 citations

Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane

2002 • 88 citations

Nutrient sensing in the mTOR/S6K1 signalling pathway

2007 • 88 citations

An essential role for a protein and lipid kinase complex in secretory protein sorting

1992 • 86 citations

Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio

2003 • 82 citations

Class IB-Phosphatidylinositol 3-Kinase (PI3K) Deficiency Ameliorates IA-PI3K-Induced Systemic Lupus but Not T Cell Invasion

2006 • 81 citations

The role of SMG-1 in nonsense-mediated mRNA decay

2005 • 78 citations

Polo-like Kinases Inhibited by Wortmannin

2006 • 77 citations

Identification and cDNA Cloning of a Novel Mammalian C2 Domain-Containing Phosphoinositide 3-Kinase, HsC2-PI3K

1997 • 66 citations

Expression analysis of genes at 3q26-q27 involved in frequent amplification in squamous cell lung carcinoma

1999 • 65 citations

Auto-antibodies and autoreactive T-cells in rheumatoid arthritis

2007 • 59 citations

cDNA Cloning of a Third Human C2-Domain-Containing Class II Phosphoinositide 3-Kinase, PI3K-C2γ, and Chromosomal Assignment of This Gene (PIK3C2G) to 12p12

1998 • 59 citations

Mammalian Phosphatidylinositol 4‐Kinases

2003 • 57 citations

Nuclear localization of phosphatidylinositol 4-kinase β

2002 • 55 citations

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors

2007 • 54 citations

NTAL/LAB and LAT: a balancing act in mast-cell activation and function

2005 • 52 citations

Discovery of 3,3‘-(2,4-Diaminopteridine-6,7-diyl)diphenol as an Isozyme-Selective Inhibitor of PI3K for the Treatment of Ischemia Reperfusion Injury Associated with Myocardial Infarction

2007 • 51 citations

Type II Collagen‐induced Arthritis

1985 • 48 citations

Ablation of Phosphoinositide 3-Kinase-γ Reduces the Severity of Acute Pancreatitis

2004 • 47 citations

Check, Double Check: The G2 Barrier to Cancer

2006 • 45 citations

Crystal structure and absolute configuration of Wortmannin and of Wortmannin p-bromobenzoate

1972 • 45 citations

Mammalian Phosphatidylinositol 4-Kinases

2003 • 44 citations

Fungal products. Part III. Structure of wortmannin and some hydrolysis products

1972 • 42 citations

Identification of a Small-Molecule Inhibitor of Class Ia PI3Ks with Cell-Based Screening

2007 • 41 citations

An oncogenic fusion product of the phosphatidylinositol 3-kinase p85β subunit and HUMORF8, a putative deubiquitinating enzyme

1998 • 39 citations

Creating Chemical Diversity to Target Protein Kinases

2004 • 38 citations

Cloning of human p55γ, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor

1998 • 38 citations

Sites of Action of Protein Kinase C and Phosphatidylinositol 3-Kinase Are Distinct in Oxidized Low Density Lipoprotein-induced Macrophage Proliferation

2000 • 30 citations

Immunohistochemical localisation of two phosphatidylinositol 4-kinase isoforms, PI4K230 and PI4K92, in the central nervous system of rats

2000 • 29 citations

Identification and Chromosome Assignment of a Human Gene Encoding a Novel Phosphatidylinositol-3 kinase

1997 • 28 citations

Demethoxyviridin and demethoxyviridiol: new fungal metabolites

1975 • 26 citations

DNA Repair: How to PIKK a Partner

2005 • 24 citations

Granulocyte/macrophage Colony-stimulating Factor Plays an Essential Role in Oxidized Low Density Lipoprotein-induced Macrophage Proliferation

2000 • 23 citations

Phosphoinositide 3‐kinase γ controls autonomic regulation of the mouse heart through G_i‐independent downregulation of cAMP level

2004 • 22 citations

Design strategies for protein kinase inhibitors.

2004 • 21 citations

Isoform-selective PI3K inhibitors as novel therapeutics for the treatment of acute myocardial infarction

2007 • 20 citations

Synthesis and Activity of C11-Modified Wortmannin Probes for PI3 Kinase

2005 • 18 citations

Localization of two distinct type III phosphatidylinositol 4-kinase enzyme mRNAs in the rat

2000 • 18 citations

Chromosomal localization of human p85 alpha, a subunit of phosphatidylinositol 3-kinase, and its homologue p85 beta.

1992 • 17 citations

IN VITRO METABOLISM OF THE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR, WORTMANNIN, BY CARBONYL REDUCTASE

2004 • 16 citations

The structure of wortmannin, a steroidal fungal metabolite

1968 • 15 citations

Fungal products. Part 21. Biosynthesis of the fungal metabolite, wortmannin, from [1,2-13C2]-acetate

1979 • 15 citations

p110δ is required for innate immunity to transplantable lymphomas

2007 • 15 citations

Synthesis of fluorescent derivatives of wortmannin and demethoxyviridin as probes for phosphatidylinositol 3-kinase

2006 • 12 citations

Deleted Work

1955 • 0 citations