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1982 • 10,680 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

PKB/Akt

2001 • 1,066 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Mutation of the PIK3CA Gene in Ovarian and Breast Cancer

2004 • 898 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1999 • 689 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

PTEN: Life as a Tumor Suppressor

2001 • 670 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Mutations in a signalling pathway

2005 • 551 citations

PIK3CA as an oncogene in cervical cancer

2000 • 432 citations

6-Alkylamino- and 2,3-Dihydro-3‘-methoxy-2-phenyl-4-quinazolinones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

2000 • 398 citations

Using structure to define the function of phosphoinositide 3‐kinase family members

1997 • 230 citations

Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents

2003 • 138 citations

Therapeutic Potential of Phosphoinositide 3-Kinase Inhibitors

2003 • 126 citations

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin.

1995 • 114 citations

Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase. 2. Identification and Structure−Activity Relationships of a Novel Series of N-Alkyl-N-(heteroaryl-substituted benzyl)-N‘-arylureas

1998 • 57 citations

Oxanilic acids, a new series of orally active antiallergic agents

1975 • 51 citations

A Surprising Function for the PTEN Tumor Suppressor

1998 • 41 citations

Photoinduced Single Electron Transfer on 5-Aryl-1,2,4-oxadiazoles: Some Mechanistic Investigations in the Synthesis of Quinazolin-4-ones

1999 • 27 citations

Synthesis and SAR of 5-, 6-, 7- and 8-Aza Analogues of 3-Aryl-4-hydroxyquinolin-2(1H)-one as NMDA/Glycine Site Antagonists

2001 • 20 citations

3,6-Bis-substituted s-Tetrazines

1979 • 15 citations

Mechanism of Hydrolysis of Ethyl Benzimidates in Acidic Solutions

1965 • 12 citations

166. Synthetic antimalarials. Part XVI. 4-Dialkylaminoalkylaminoquinazolines. Variation of substituents in the 6- and 7-positions

1947 • 11 citations

Syntheses of Ortho-Hydroxymethylpyridinols and Dioxaphosphorino[m,n-x]pyridines

1996 • 11 citations