Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

1989 • 933 citations

Phosphatidylinositol 3-Kinase Encoded by Yeast VPS 34 Gene Essential for Protein Sorting

1993 • 909 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

Phosphatidylinositol 3-kinase: Structure and expression of the 110 kd catalytic subunit

1992 • 692 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

The Receptor with High Affinity for Immunoglobulin E

1986 • 540 citations

Activation of phosphatidylinositol 3-kinase by insulin.

1990 • 531 citations

Role of Phosphatidylinositol Kinase in PDGF Receptor Signal Transduction

1989 • 516 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

Wortmannin, a microbial product inhibitor of myosin light chain kinase.

1992 • 434 citations

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

1993 • 369 citations

The mechanism of the calcium signal and correlation with histamine release in 2H3 cells.

1984 • 351 citations

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

1989 • 342 citations

Phosphoinositide kinases

1990 • 331 citations

Evidence for two distinct phosphatidylinositol kinases in fibroblasts. Implications for cellular regulation

1987 • 307 citations

An inositol tetrakisphosphate-containing phospholipid in activated neutrophils

1988 • 292 citations

Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

1990 • 266 citations

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1989 • 256 citations

Phosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinase.

1990 • 244 citations

Activation of phosphatidylinositol 3-kinase in cells expressing abl oncogene variants.

1991 • 224 citations

Activation of human neutrophil phospholipase D by three separable mechanisms

1990 • 220 citations

The calcium signal and phosphatidylinositol breakdown in 2H3 cells.

1984 • 214 citations

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

1992 • 212 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.

1991 • 184 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Calcium-dependent protein phosphorylation during secretion by exocytosis in the mast cell

1978 • 167 citations

Antigen-induced Secretion of Histamine and the Phosphorylation of Myosin by Protein Kinase C in Rat Basophilic Leukemia Cells

1989 • 161 citations

Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells.

1993 • 160 citations

Different isozymes of protein kinase C mediate feedback inhibition of phospholipase C and stimulatory signals for exocytosis in rat RBL-2H3 cells.

1993 • 158 citations

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1991 • 151 citations

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1987 • 142 citations

Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution.

1992 • 137 citations

Quantitative relationships between aggregation of IgE receptors, generation of intracellular signals, and histamine secretion in rat basophilic leukemia (2H3) cells. Enhanced responses with heavy water.

1986 • 133 citations

Fc epsilon R1-mediated tyrosine phosphorylation of multiple proteins, including phospholipase C gamma 1 and the receptor beta gamma 2 complex, in RBL-2H3 rat basophilic leukemia cells.

1992 • 132 citations

Membrane Ig cross-linking regulates phosphatidylinositol 3-kinase in B lymphocytes.

1992 • 128 citations

Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains

1992 • 123 citations

Receptor-coupled phospholipase D and its inhibition

1991 • 119 citations

Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1.

1992 • 119 citations

Demethoxyviridin and wortmannin block phospholipase C and D activation in the human neutrophil

1991 • 118 citations

Wortmannin, an antibiotic produced by Penicillium wortmanni

1957 • 112 citations

Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction.

1991 • 109 citations

Phospholipid methylation affects immunoglobulin E-mediated histamine and arachidonic acid release in rat leukemic basophils

1980 • 106 citations

Phosphatidylinositol kinase type I activity associates with various oncogene products.

1989 • 98 citations

H-2-restricted cytotoxic effectors generated in vitro by the addition of trinitrophenyl-conjugated soluble proteins

1978 • 83 citations

Differential activation of human basophils by anti‐IgE and formyl‐methionyl‐leucylphenylalanine. Indications for protein kinase C‐dependent and ‐independent activation pathways

1991 • 78 citations

Studies of protein kinase C in the rat basophilic leukemia (RBL-2H3) cell reveal that antigen-induced signals are not mimicked by the actions of phorbol myristate acetate and Ca2+ ionophore.

1989 • 71 citations

Isolation and purification of a hemorrhagic factor (wortmannin) from Fusarium oxysporum (N17B)

1988 • 66 citations

Antiinflammatory activity of the new mould metabolite 11-desacetoxy-wortmannin and of some of its derivatives

1974 • 65 citations

The effect of pertussis toxin on mediator release from human basophils.

1987 • 65 citations

Novel polyphosphoinositides in cell growth and activation.

1991 • 61 citations

Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction.

1990 • 55 citations

Two thrombin-activated Ca2+ channels in human platelets.

1992 • 55 citations

Suppression by wortmannin of platelet responses to stimuli due to inhibition of pleckstrin phosphorylation

1992 • 51 citations

Certain inhibitors of protein serine/threonine kinases also inhibit tyrosine phosphorylation of phospholipase C gamma 1 and other proteins and reveal distinct roles for tyrosine kinase(s) and protein kinase C in stimulated, rat basophilic RBL-2H3 cells.

1992 • 51 citations

Tyrosine phosphorylation of phospholipase C γ₁ couples the FCη receptor mediated signal to mast cells secretion

1992 • 50 citations

Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways.

1991 • 49 citations

Purification and characterization of membrane-bound phosphatidylinositol kinase from rat brain.

1988 • 49 citations

Phospholipase C-gamma 1 is translocated to the membrane of rat basophilic leukemia cells in response to aggregation of IgE receptors.

1992 • 45 citations

Inhibition of IgE-mediated histamine release by myosin light chain kinase inhibitors

1992 • 43 citations

Fungal products. Part III. Structure of wortmannin and some hydrolysis products

1972 • 42 citations

Inhibition of Ca2+-dependent catecholamine release by myosin light chain kinase inhibitor, wortmannin, in adrenal chromaffin cells

1992 • 41 citations

Selektive Funktionalisierung von Wortmannin mit Hilfe einer Furanring‐Maskierung

1975 • 30 citations

Immunosuppressive Effects of Dietary Wortmannin on Rats and Mice

1989 • 21 citations

[22] Phosphatidylinositol 4-kinases and phosphatidylinositol-4-phosphate 5-kinases from bovine brain brain membranes

1992 • 14 citations

Enhancement of the phosphorylation of membrane bound myosin light chain by antigen stimulation in rat basophilic leukemia cells

1989 • 10 citations

High-performance liquid chromatographic method for the evaluation of possible interferences in basophil-histamine release measurements

1990 • 7 citations

Rapid phosphorylation of a 92,000 MW protein on activation of rat basophilic leukaemia cells for histamine release.

1987 • 6 citations