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Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110α inhibitors

Data up to Jan 2025

Published2007
Citations134
References29

Total Citations Per Year

Abstract

References (29)

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

2006 • 1,119 citations

PKB/Akt

2001 • 1,066 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Mutation of the PIK3CA Gene in Ovarian and Breast Cancer

2004 • 898 citations

Signaling by Distinct Classes of Phosphoinositide 3-Kinases

1999 • 861 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

1999 • 689 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

PTEN: Life as a Tumor Suppressor

2001 • 670 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

2006 • 587 citations

Mutations in a signalling pathway

2005 • 551 citations

PIK3CA as an oncogene in cervical cancer

2000 • 432 citations

Isolation of amplified and overexpressed DNA sequences from adriamycin-resistant human breast cancer cells.

1987 • 296 citations

Using structure to define the function of phosphoinositide 3‐kinase family members

1997 • 230 citations

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors

2006 • 188 citations

Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents

2003 • 138 citations

Therapeutic Potential of Phosphoinositide 3-Kinase Inhibitors

2003 • 126 citations

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110α inhibitors

2006 • 122 citations

In vitro and in vivo antitumor activity of the phosphatidylinositol-3-kinase inhibitor, wortmannin.

1995 • 114 citations

A Surprising Function for the PTEN Tumor Suppressor

1998 • 41 citations

Synthesis of pyrido[3′,2′:4,5] thieno[3,2‐d]pyrimidine derivatives

1974 • 30 citations

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Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives… (2007) – Bioorganic & Medicinal Chemistry Letters | Metascience Observatory Explorer