mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

2003 • 7,305 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 • 5,837 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

2004 • 3,444 citations

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

2006 • 3,099 citations

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 • 2,561 citations

Metformin and reduced risk of cancer in diabetic patients

2005 • 2,278 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

Ras, PI(3)K and mTOR signalling controls tumour cell growth

2006 • 1,934 citations

The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

2005 • 1,901 citations

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

2004 • 1,631 citations

Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 • 1,358 citations

Hypothalamic mTOR Signaling Regulates Food Intake

2006 • 1,217 citations

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

2006 • 1,210 citations

Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer

2004 • 1,148 citations

Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40

2007 • 1,132 citations

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

2006 • 1,119 citations

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

2004 • 1,101 citations

The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 • 1,056 citations

Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

2006 • 1,038 citations

Hepatocellular carcinoma: Recent trends in the United States

2004 • 973 citations

Randomized Phase II Study of Multiple Dose Levels of CCI-779, a Novel Mammalian Target of Rapamycin Kinase Inhibitor, in Patients With Advanced Refractory Renal Cell Carcinoma

2004 • 958 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR

2003 • 927 citations

Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 • 773 citations

Plasma Amino Acid Levels and Insulin Secretion in Obesity

1969 • 772 citations

Overweight as an avoidable cause of cancer in Europe

2001 • 755 citations

Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

2005 • 744 citations

Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study

2005 • 698 citations

mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

2006 • 668 citations

Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling

2002 • 654 citations

Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

2006 • 650 citations

Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?

2005 • 643 citations

Rapamycin causes regression of astrocytomas in tuberous sclerosis complex

2006 • 616 citations

mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells

2004 • 606 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

2006 • 587 citations

Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis

2006 • 587 citations

The NF1 tumor suppressor critically regulates TSC2 and mTOR

2005 • 582 citations

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

2004 • 562 citations

Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family

1998 • 545 citations

hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase

2005 • 519 citations

The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation

2005 • 490 citations

Rheb fills a GAP between TSC and TOR

2003 • 467 citations

Phase II Study of Temsirolimus (CCI-779), a Novel Inhibitor of mTOR, in Heavily Pretreated Patients With Locally Advanced or Metastatic Breast Cancer

2005 • 467 citations

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

2004 • 464 citations

Regulation of mTOR and Cell Growth in Response to Energy Stress by REDD1

2005 • 432 citations

Akt-dependent transformation: there is more to growth than just surviving

2005 • 430 citations

PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR

2006 • 373 citations

The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses

2005 • 357 citations

Reduced Activation of Phosphatidylinositol-3 Kinase and Increased Serine 636 Phosphorylation of Insulin Receptor Substrate-1 in Primary Culture of Skeletal Muscle Cells From Patients With Type 2 Diabetes

2003 • 297 citations

Risk of mortality and adverse cardiovascular outcomes in type 2 diabetes: a comparison of patients treated with sulfonylureas and metformin

2006 • 289 citations

Nutrition, Insulin, Insulin-like Growth Factors and Cancer

2003 • 271 citations

A Novel Method for Measurement of Submembrane ATP Concentration

2000 • 270 citations

Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1

2006 • 247 citations

Rapamycin synergizes with the epidermal growth factor receptor inhibitor erlotinib in non–small-cell lung, pancreatic, colon, and breast tumors

2006 • 235 citations

<scp>L</scp>‐type amino acid transporter 1 as a potential molecular target in human astrocytic tumors

2006 • 233 citations

Obesity and risk of cancer in Japan

2004 • 216 citations

Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

2005 • 216 citations

The amino acid sensitive TOR pathway from yeast to mammals

2006 • 212 citations

Splanchnic glucose and amino acid metabolism in obesity.

1974 • 206 citations

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1

2002 • 187 citations

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

2002 • 180 citations

Turnover of the Active Fraction of IRS1 Involves Raptor-mTOR- and S6K1-Dependent Serine Phosphorylation in Cell Culture Models of Tuberous Sclerosis

2006 • 175 citations

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

2004 • 135 citations

Uncoupling insulin signalling by serine/threonine phosphorylation: a molecular basis for insulin resistance

2004 • 111 citations

Cancer Targets in the Ras Pathway

2005 • 109 citations

G-protein-coupled receptors and tyrosine kinases: crossroads in cell signaling and regulation

2006 • 103 citations

hvps34, an ancient player, enters a growing game: mTOR Complex1/S6K1 signaling

2007 • 102 citations

A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion

2002 • 99 citations

Nutrient sensor links obesity with diabetes risk

2004 • 71 citations

Characterization of a Conserved C-terminal Motif (RSPRR) in Ribosomal Protein S6 Kinase 1 Required for Its Mammalian Target of Rapamycin-dependent Regulation

2005 • 56 citations

Overexpression of LAT1/CD98 Light Chain Is Sufficient to Increase System l-Amino Acid Transport Activity in Mouse Hepatocytes but Not Fibroblasts

2001 • 56 citations

Leucine regulation of glucokinase and ATP synthase sensitizes glucose-induced insulin secretion in pancreatic beta-cells.

2006 • 54 citations

Leucine Regulation of Glucokinase and ATP Synthase Sensitizes Glucose-Induced Insulin Secretion in Pancreatic β-Cells

2006 • 50 citations

Mammalian Target of Rapamycin Inhibitors in Combination with Letrozole in Breast Cancer

2006 • 48 citations

Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: Mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity

2000 • 48 citations

Nutrition, energy balance and colon cancer risk: the role of insulin and insulin-like growth factor-I.

2002 • 26 citations

Are Plasma Amino Acid Levels Elevated in Obesity?

1970 • 26 citations

Rapamycin together with herceptin significantly increased anti‐tumor efficacy compared to either alone in ErbB2 over expressing breast cancer cells

2007 • 24 citations

Effects of Insulin on Free Amino Acids in Plasma and the Role of the Amino Acid Metabolism in the Etiology of Diabetic Microangiopathy

1993 • 16 citations