Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Ras, PI(3)K and mTOR signalling controls tumour cell growth

2006 • 1,934 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

PIK3CA is implicated as an oncogene in ovarian cancer

1999 • 1,170 citations

Ten years of protein kinase B signalling: a hard Akt to follow

2001 • 1,159 citations

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

2000 • 1,121 citations

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

2006 • 1,119 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Mutant PIK3CA promotes cell growth and invasion of human cancer cells

2005 • 873 citations

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

2005 • 813 citations

Pharmacokinetic/pharmacodynamic data analysis : concepts and applications

2002 • 718 citations

United Kingdom Co-ordinating Committee on Cancer Research (UKCCCR) Guidelines for the Welfare of Animals in Experimental Neoplasia (Second Edition)

1998 • 659 citations

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 • 596 citations

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

2006 • 587 citations

Structural insights into phosphoinositide 3-kinase catalysis and signalling

1999 • 478 citations

Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines

1999 • 470 citations

Signalling by PI3K isoforms: insights from gene-targeted mice

2005 • 432 citations

Antitumor Activity of ZSTK474, a New Phosphatidylinositol 3-Kinase Inhibitor

2006 • 381 citations

PTEN: from pathology to biology

2003 • 345 citations

Mutations of PIK3CA in Anaplastic Oligodendrogliomas, High-Grade Astrocytomas, and Medulloblastomas

2004 • 340 citations

The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells

1999 • 317 citations

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling

2004 • 307 citations

G₁ cell cycle progression and the expression of G₁ cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells

2004 • 302 citations

Oncogenic transformation induced by the p110β, -γ, and -δ isoforms of class I phosphoinositide 3-kinase

2006 • 272 citations

Role of the Pi3k Regulatory Subunit in the Control of Actin Organization and Cell Migration

2000 • 245 citations

Phosphoinositide 3-Kinase Signalling Pathways in Tumor Progression, Invasion and Angiogenesis

2004 • 220 citations

In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

1998 • 194 citations

Activation of the CPP32 Apoptotic Protease by Distinct Signaling Pathways with Differential Sensitivity to Bcl-xL

1996 • 190 citations

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110α inhibitors

2006 • 188 citations

Opportunities and challenges in the development of kinase inhibitor therapy for cancer

2003 • 171 citations

Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration

2005 • 160 citations

The phosphatidylinositol-3-kinase inhibitor PX-866 overcomes resistance to the epidermal growth factor receptor inhibitor gefitinib in A-549 human non–small cell lung cancer xenografts

2005 • 149 citations

The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway.

1998 • 145 citations

Synthesis and biological evaluation of pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110α inhibitors

2007 • 134 citations

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis

2006 • 108 citations

Targeting Serine / Threonine Protein Kinase B / Akt and Cell-cycle Checkpoint Kinases for Treating Cancer

2002 • 105 citations

Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026

2005 • 94 citations

Requirement for PI 3-kinase γ in macrophage migration to MCP-1 and CSF-1

2003 • 92 citations

Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment

2004 • 85 citations

LY294002 and LY303511 Sensitize Tumor Cells to Drug-Induced Apoptosis via Intracellular Hydrogen Peroxide Production Independent of the Phosphoinositide 3-Kinase-Akt Pathway

2005 • 83 citations

Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185.

1994 • 81 citations

PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors

2005 • 66 citations

Drugging the PI3 kinome

2006 • 63 citations

Growth inhibition of human malignant glioma cells induced by the PI3-K—specific inhibitor

2003 • 39 citations

TSC1-2 tumour suppressor and regulation of mTOR signalling: linking cell growth and proliferation?

2004 • 38 citations

Therapeutic potential of phosphoinositide 3-kinase inhibitors

2004 • 35 citations

PLC and PI3K Pathways are Important in the Inhibition of EGF-lnduced Cell Migration by Gefitinib (‘lressa’, ZD1839)

2004 • 33 citations

The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck

2005 • 30 citations

Evaluation of the cassette dosing approach for assessing the pharmacokinetics of geldanamycin analogues in mice

2004 • 21 citations

Intracellular signalling and cancer: complex pathways lead to multiple targets

2004 • 18 citations

Identification of novel effectors of invasive cell growth downstream of phosphoinositide 3-kinase

2004 • 6 citations