Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

2005 • 6,083 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

2004 • 1,178 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium salt XTT

1991 • 994 citations

ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

2004 • 979 citations

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

2000 • 922 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

The many substrates and functions of ATM

2000 • 777 citations

Toward Maintaining the Genome: DNA Damage and Replication Checkpoints

2002 • 773 citations

A quantitative assay for HIV DNA integration in vivo

2001 • 692 citations

ATM and ATR: networking cellular responses to DNA damage

2001 • 595 citations

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1998 • 533 citations

Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

2000 • 500 citations

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice

2000 • 425 citations

Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection

2001 • 351 citations

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

2003 • 331 citations

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

2000 • 278 citations

A Role for DNA-PK in Retroviral DNA Integration

1999 • 255 citations

Recombinant ATM protein complements the cellular A-T phenotype

1997 • 242 citations

Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection

1996 • 232 citations

Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice

2000 • 170 citations

Direct Effects of Caffeine and Theophylline on p110δ and Other Phosphoinositide 3-Kinases

2002 • 151 citations

Caffeine Inhibits Checkpoint Responses without Inhibiting the Ataxia-Telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) Protein Kinases

2003 • 147 citations

Roles of host cell factors in circularization of retroviral dna

2003 • 122 citations

DNA Damage Sensors ATM, ATR, DNA-PKcs, and PARP-1 Are Dispensable for Human Immunodeficiency Virus Type 1 Integration

2005 • 118 citations

Evidence that the retroviral DNA integration process triggers an ATR-dependent DNA damage response

2003 • 100 citations

Evaluation of synergism or antagonism for the combined action of antiviral agents

1990 • 98 citations

Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration

2001 • 97 citations

Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine

2004 • 88 citations

Wortmannin Potentiates Integrase-Mediated Killing of Lymphocytes and Reduces the Efficiency of Stable Transduction by Retroviruses

2001 • 79 citations

Effect of Ku80 Depletion on the Preintegrative Steps of HIV-1 Replication in Human Cells

2002 • 75 citations

Suppression of retroviral infection by the RAD52 DNA repair protein

2004 • 74 citations

Efficient retroviral infection of mammalian cells is blocked by inhibition of poly(ADP-ribose) polymerase activity

1996 • 57 citations

Histone H2AX Is Phosphorylated at Sites of Retroviral DNA Integration but Is Dispensable for Postintegration Repair

2004 • 56 citations

The Ataxia Telangiectasia-Mutated and Rad3-Related Protein Is Dispensable for Retroviral Integration

2005 • 49 citations

Drug Resistance and Drug Combination Features of the Human Immunodeficiency Virus Inhibitor, BCH-10652 [(±)-2′-Deoxy-3′-Oxa-4′-Thiocytidine, dOTC]

2000 • 37 citations

Poly(ADP-Ribose) Polymerase 1 Is Not Strictly Required for Infection of Murine Cells by Retroviruses

2002 • 32 citations

Processing of an HIV Replication Intermediate by the Human DNA Replication Enzyme FEN1

1998 • 29 citations

Stimulation of human flap endonuclease 1 by human immunodeficiency virus type 1 integrase: Possible role for flap endonuclease 1 in 5′-end processing of human immunodeficiency virus type 1 integration intermediates

2002 • 12 citations