Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Involvement of chemokine receptors in breast cancer metastasis

2001 • 5,203 citations

High Frequency of Mutations of the PIK3CA Gene in Human Cancers

2004 • 3,304 citations

PI3K/Akt signalling pathway and cancer

2003 • 2,157 citations

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients

2004 • 1,810 citations

Cell migration: Rho GTPases lead the way

2003 • 1,412 citations

The tor pathway: a target for cancer therapy

2004 • 1,308 citations

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR

2001 • 981 citations

Role of Src expression and activation in human cancer

2000 • 832 citations

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

2000 • 805 citations

Interleukin-8 and human cancer biology

2001 • 679 citations

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

2002 • 584 citations

Phosphoinositide Recognition Domains

2003 • 556 citations

Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity

1999 • 539 citations

Ras Protein Farnesyltransferase: A Strategic Target for Anticancer Therapeutic Development

1999 • 538 citations

Oncogenic Mutations of PIK3CA in Human Cancers

2004 • 502 citations

Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase

2004 • 485 citations

The role of phosphoinositides in membrane transport

2001 • 482 citations

PTEN signaling pathways in melanoma

2003 • 472 citations

The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease

2004 • 468 citations

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

2002 • 460 citations

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

2004 • 460 citations

Molecular Mechanism for the Regulation of Protein Kinase B/Akt by Hydrophobic Motif Phosphorylation

2002 • 416 citations

Phosphoinositide 3-kinase signalling – which way to target?

2003 • 412 citations

Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

2004 • 384 citations

Directional Sensing Requires Gβγ-Mediated PAK1 and PIXα-Dependent Activation of Cdc42

2003 • 380 citations

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors

2004 • 349 citations

P<scp>hosphoinositide</scp>3-K<scp>inase</scp>: Diverse Roles in Immune Cell Activation

2004 • 341 citations

Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions

2003 • 322 citations

Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

2002 • 293 citations

Genetic Alterations and Aberrant Expression of Genes Related to the Phosphatidyl‐lnositol‐3′‐Kinase/Protein Kinase B (Akt) Signal Transduction Pathway in Glioblastomas

2003 • 233 citations

The Class II Phosphoinositide 3-Kinase C2α Is Activated by Clathrin and Regulates Clathrin-Mediated Membrane Trafficking

2001 • 217 citations

The Effects of Insulin-Like Growth Factors on Tumorigenesis and Neoplastic Growth

2000 • 206 citations

Control of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead

2004 • 201 citations

Inhibition of the mammalian target of rapamycin sensitizes U87 xenografts to fractionated radiation therapy.

2002 • 200 citations

14-3-3 Proteins Modulate the Expression of Epithelial Na+ Channels by Phosphorylation-dependent Interaction with Nedd4-2 Ubiquitin Ligase

2005 • 188 citations

Phosphoinositide 3-kinase regulates β2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/β-arrestin complex

2002 • 184 citations

Inducible shRNA expression for application in a prostate cancer mouse model

2003 • 174 citations

Membrane Recognition and Targeting by Lipid-Binding Domains

2003 • 173 citations

Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway

2004 • 169 citations

Protein Kinase C βII Regulates Akt Phosphorylation on Ser-473 in a Cell Type- and Stimulus-specific Fashion

2004 • 167 citations

Tuberous sclerosis complex: from Drosophila to human disease

2004 • 160 citations

Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571

2002 • 154 citations

Defective dendritic cell migration and activation of adaptive immunity in PI3Kγ-deficient mice

2004 • 147 citations

Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation

2004 • 144 citations

Oncogenic growth factor receptors: implications for signal transduction therapy

2004 • 143 citations

Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors. Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis

2004 • 143 citations

Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles

2004 • 141 citations

Protection from angiotensin II–mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ

2005 • 141 citations

Bcr–Abl variants: biological and clinical aspects

2002 • 133 citations

A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells

2000 • 132 citations

The biology of Kit in disease and the application of pharmacogenetics

2004 • 122 citations

PTEN and phosphatidylinositol 3'-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment.

2003 • 120 citations

Activation Loop Sequences Confer Substrate Specificity to Phosphoinositide 3-Kinase α (PI3Kα)

2001 • 88 citations

Roles of Stem Cell Factor/c-Kit and Effects of Glivec®/STI571 in Human Uveal Melanoma Cell Tumorigenesis

2004 • 84 citations

Topical Treatment with Inhibitors of the Phosphatidylinositol 3′-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice

2004 • 75 citations

Inhibition of phosphatidylinositol 3′-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway

2004 • 75 citations

G1 phase arrest by the phosphatidylinositol 3‐kinase inhibitor LY 294002 is correlated to up‐regulation of p27^Kip1 and inhibition of G1 CDKs in choroidal melanoma cells

1998 • 73 citations

Constitutive activation of PI3K is involved in the spontaneous proliferation of primary acute myeloid leukemia cells: direct evidence of PI3K activation

2004 • 67 citations

Assigning Functional Domains within the p101 Regulatory Subunit of Phosphoinositide 3-Kinase γ

2004 • 64 citations

Expression of the proto-oncogene c-KIT in normal and tumor tissues from colorectal carcinoma patients

2004 • 49 citations

Autotaxin promotes motility via G protein‐coupled phosphoinositide 3‐kinase γ in human melanoma cells

2002 • 38 citations

Multiple Domains of Ruk/CIN85/SETA/CD2BP3 are Involved in Interaction with p85α Regulatory Subunit of PI 3-kinase

2004 • 26 citations