Wortmannin, a Widely Used Phosphoinositide 3-Kinase Inhibitor, also Potently Inhibits Mammalian Polo-like Kinase

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

1996 • 685 citations

Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 • 673 citations

Chemistry-Based Functional Proteomics Reveals Novel Members of the Deubiquitinating Enzyme Family

2002 • 565 citations

Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools

2000 • 564 citations

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

1988 • 546 citations

The Polo-like kinase Cdc5p and the WD-repeat protein Cdc20p/fizzy are regulators and substrates of the anaphase promoting complex in Saccharomyces cerevisiae

1998 • 488 citations

Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

2003 • 465 citations

Activity-based probes for the proteomic profiling of metalloproteases

2004 • 439 citations

Polo-like kinases: a team that plays throughout mitosis

1998 • 424 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

1995 • 376 citations

Profiling Serine Hydrolase Activities in Complex Proteomes

2001 • 361 citations

Polo-like kinases: positive regulators of cell division from start to finish

1998 • 346 citations

Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness

2002 • 344 citations

Prognostic significance of polo-like kinase (PLK) expression in non-small cell lung cancer

1997 • 320 citations

Chemical Approaches for Functionally Probing the Proteome

2002 • 293 citations

A Role for the Protease Falcipain 1 in Host Cell Invasion by the Human Malaria Parasite

2002 • 284 citations

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

2001 • 278 citations

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5

1994 • 275 citations

Malignant Transformation of Mammalian Cells Initiated by Constitutive Expression of thePolo-like Kinase1

1997 • 246 citations

Prognostic significance of polo-like kinase (PLK) expression in squamous cell carcinomas of the head and neck.

1999 • 228 citations

Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype

2002 • 224 citations

The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts

1998 • 214 citations

The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase

2000 • 203 citations

Phosphorylation of Threonine 210 and the Role of Serine 137 in the Regulation of Mammalian Polo-like Kinase

2002 • 201 citations

The Identification and Characterization of the Marine Natural Product Scytonemin as a Novel Antiproliferative Pharmacophore

2002 • 200 citations

The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs

1998 • 190 citations

Polo-like Kinase Is a Cell Cycle-regulated Kinase Activated during Mitosis

1995 • 165 citations

Wiley encyclopedia of molecular medicine

2002 • 158 citations

Chemical strategies for the global analysis of protein function

2000 • 156 citations

The Polo-like Kinase Plx1 Is Required for Activation of the Phosphatase Cdc25C and Cyclin B-Cdc2 inXenopusOocytes

2001 • 155 citations

Profiling the specific reactivity of the proteome with non-directed activity-based probes

2001 • 150 citations

Cell Cycle Regulation of the Human Polo-like Kinase (PLK) Promoter

1997 • 130 citations

Polo kinase and Asp are needed to promote the mitotic organizing activity of centrosomes

2001 • 124 citations

Purification and Cloning of a Protein Kinase That Phosphorylates and Activates the Polo-Like Kinase Plx1

1998 • 119 citations

Mapping Enzyme Active Sites in Complex Proteomes

2004 • 97 citations

Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability

2001 • 91 citations

The conserved mitotic kinase polo is regulated by phosphorylation and has preferred microtubule-associated substrates in Drosophila embryo extracts.

1996 • 84 citations

Caspase Activation of Mammalian Sterile 20-like Kinase 3 (Mst3)

2002 • 84 citations

Inactivation of the mitotic checkpoint as a determinant of the efficacy of microtubule-targeted drugs in killing human cancer cells

2004 • 82 citations

A Model for Binding of Structurally Diverse Natural Product Inhibitors of Protein Phosphatases PP1 and PP2A

1997 • 79 citations

Trifunctional Chemical Probes for the Consolidated Detection and Identification of Enzyme Activities from Complex Proteomes

2002 • 72 citations

Stk10, a New Member of the Polo-like Kinase Kinase Family Highly Expressed in Hematopoietic Tissue

2003 • 69 citations

Association of polo-like kinase with α-, β- and γ-tubulins in a stable complex

1999 • 65 citations

Design and Synthesis of AX7574: A Microcystin-Derived, Fluorescent Probe for Serine/Threonine Phosphatases

2004 • 47 citations

Paclitaxel-Induced FasL-Independent Apoptosis and Slow (Non-Apoptotic) Cell Death

2002 • 41 citations

Ceramide involvement in homocamptothecin- and camptothecin-induced cytotoxicity and apoptosis in colon HT29 cells

2002 • 31 citations

Water-soluble HPMA copolymer–wortmannin conjugate retains phosphoinositide 3-kinase inhibitory activity in vitro and in vivo

2001 • 31 citations

Selektive Funktionalisierung von Wortmannin mit Hilfe einer Furanring‐Maskierung

1975 • 30 citations

Synthesis and in Vitro Evaluation of New Wortmannin Esters: Potent Inhibitors of Phosphatidylinositol 3-Kinase

1996 • 27 citations

The Serine/Threonine Phosphatase Inhibitor Calyculin A Induces Rapid Degradation of IκBβ

1997 • 20 citations

Association of polo-like kinase with α-, β- and γ-tubulins in a stable complex

1999 • 11 citations

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