Regulation of gene-activation pathways by PIAS proteins in the immune system

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

STATs and Gene Regulation

1997 • 3,927 citations

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Signalling pathways of the TNF superfamily: a double-edged sword

2003 • 2,602 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

The coregulator exchange in transcriptional functions of nuclear receptors

2000 • 2,219 citations

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

2002 • 2,139 citations

A signature motif in transcriptional co-activators mediates binding to nuclear receptors

1997 • 2,100 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

Protein Modification by SUMO

2004 • 1,628 citations

Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation

2004 • 1,396 citations

The IKK NF-κB system: a treasure trove for drug development

2004 • 1,340 citations

Regulation of JAK–STAT signalling in the immune system

2003 • 1,313 citations

RING Finger Proteins

2000 • 1,216 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

2002 • 787 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

SUMO—Nonclassical Ubiquitin

2000 • 764 citations

Impaired response to interferon-α/β and lethal viral disease in human STAT1 deficiency

2003 • 763 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting

2001 • 722 citations

An E3-like Factor that Promotes SUMO Conjugation to the Yeast Septins

2001 • 642 citations

The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors

1999 • 637 citations

Signaling to p53

1998 • 636 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

Development of TGF-β signalling inhibitors for cancer therapy

2004 • 536 citations

p53: traffic cop at the crossroads of DNA repair and recombination

2005 • 529 citations

Smads as transcriptional co-modulators

2000 • 522 citations

SAP – a putative DNA-binding motif involved in chromosomal organization

2000 • 499 citations

Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase

2002 • 482 citations

p63 and p73: Roles in Development and Tumor Formation

2004 • 481 citations

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53

2001 • 447 citations

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

2002 • 441 citations

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

2002 • 420 citations

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

1997 • 379 citations

Covalent Modification of p73α by SUMO-1

2000 • 376 citations

Rel/NF-κB and IκB proteins: an overview

1997 • 372 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

The T Cell Protein Tyrosine Phosphatase Is a Negative Regulator of Janus Family Kinases 1 and 3

2002 • 325 citations

The ubiquitin–protein ligase Itch regulates p73 stability

2005 • 300 citations

Functional regulation of p73 and p63: development and cancer

2003 • 278 citations

PIAS/SUMO: new partners in transcriptional regulation

2003 • 269 citations

P53 and Prognosis

2005 • 263 citations

PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity

2004 • 256 citations

SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin μ gene expression

2003 • 256 citations

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

2001 • 242 citations

Smad3: A Key Player in Pathogenetic Mechanisms Dependent on TGF‐β

2003 • 231 citations

PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription

2002 • 208 citations

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

2001 • 198 citations

The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family

2001 • 188 citations

SAF-Box, a Conserved Protein Domain That Specifically Recognizes Scaffold Attachment Region DNA

2000 • 187 citations

Regulating the p53 system through ubiquitination

2004 • 179 citations

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

2003 • 173 citations

Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells

2001 • 167 citations

SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation

2003 • 166 citations

Versatile protein tag, SUMO: Its enzymology and biological function

2002 • 163 citations

The intranuclear prolactin/cyclophilin B complex as a transcriptional inducer

2002 • 158 citations

PIAS proteins promote SUMO-1 conjugation to STAT1

2003 • 150 citations

Negative Regulation of NF-κB Signaling by PIAS1

2005 • 144 citations

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

2000 • 133 citations

Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus

1996 • 133 citations

A Drosophila PIAS homologue negatively regulates stat92E

2001 • 127 citations

PIASx Is a Transcriptional Co-repressor of Signal Transducer and Activator of Transcription 4

2003 • 121 citations

Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4

2003 • 120 citations

Distinct roles of the NH ₂ - and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1–Stat1 interaction

2000 • 119 citations

Incredible journey: how do developmental signals travel through tissue?

2004 • 115 citations

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT

2003 • 107 citations

PIAS3 induces SUMO‐1 modification and transcriptional repression of IRF‐1

2002 • 103 citations

Intracellular Targeting of Proteins by Sumoylation

2001 • 102 citations

Activation of Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3)

2003 • 97 citations

Sumoylation of Mdm2 by Protein Inhibitor of Activated STAT (PIAS) and RanBP2 Enzymes

2002 • 97 citations

SUMO-1 conjugation selectively modulates STAT1-mediated gene responses

2005 • 96 citations

PIAS3 Suppresses NF-κB-mediated Transcription by Interacting with the p65/RelA Subunit

2004 • 96 citations

Post-translational Modification of Rta of Epstein-Barr Virus by SUMO-1

2004 • 94 citations

Protein Inhibitor of Activated STAT Y (PIASy) and a Splice Variant Lacking Exon 6 Enhance Sumoylation but Are Not Essential for Embryogenesis and Adult Life

2004 • 93 citations

Physical and functional interactions of histone deacetylase 3 with TFII-I family proteins and PIASxβ

2002 • 92 citations

NMR Structure of the N-terminal Domain of SUMO Ligase PIAS1 and Its Interaction with Tumor Suppressor p53 and A/T-rich DNA Oligomers

2004 • 91 citations

A New Role for the STAT3 Inhibitor, PIAS3

2002 • 91 citations

PIASy-mediated repression of the androgen receptor is independent of sumoylation

2004 • 88 citations

Activation of p53 by Protein Inhibitor of Activated Stat1 (PIAS1)

2002 • 88 citations

PIASy-Deficient Mice Display Modest Defects in IFN and Wnt Signaling

2004 • 87 citations

Abnormal Expression of Mouse Mast Cell Protease 5 Gene in Cultured Mast Cells Derived From Mutant mi/mi Mice

1997 • 87 citations

The STAT family of proteins in cytokine signaling

1999 • 84 citations

Regulation of Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT, PIASy through Smad3

2003 • 84 citations

The ‘PINIT’ motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L

2003 • 84 citations

Regulation of Smad4 Sumoylation and Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT1

2004 • 82 citations

Modulation of mRNA Expression of a Novel Human Myeloid-Selective CCAAT/Enhancer Binding Protein Gene (C/EBPε)

1997 • 81 citations

PIAS-1 Is a Checkpoint Regulator Which Affects Exit from G₁ and G₂ by Sumoylation of p73

2004 • 78 citations

Transactivation properties of c‐Myb are critically dependent on two SUMO‐1 acceptor sites that are conjugated in a PIASy enhanced manner

2003 • 71 citations

C/EBPε Is a Myeloid-specific Activator of Cytokine, Chemokine, and Macrophage-Colony-stimulating Factor Receptor Genes

1998 • 69 citations

Interplay between MITF, PIAS3, and STAT3 in Mast Cells and Melanocytes

2004 • 61 citations

Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules

2003 • 58 citations

ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3

2003 • 55 citations

Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster

1999 • 53 citations

p73, the “Assistant” Guardian of the Genome?

2003 • 46 citations

Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein

2004 • 43 citations

PIASy represses TRIF‐induced ISRE and NF‐κB activation but not apoptosis

2004 • 42 citations

Role Played by Microphthalmia Transcription Factor Phosphorylation and Its Zip Domain in Its Transcriptional Inhibition by PIAS3

2003 • 41 citations

PIAS1 enhances SUMO‐1 modification and the transactivation activity of the major immediate–early IE2 protein of human cytomegalovirus

2003 • 40 citations

Macrophage functional maturation and cytokine production are impaired in C/EBPε-deficient mice

2002 • 39 citations

p53 leans on its siblings

2002 • 39 citations

Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation

2004 • 37 citations

Protein partners of C/EBPε

2004 • 19 citations

Repression and Coactivation of CCAAT/Enhancer-binding Protein ϵ by Sumoylation and Protein Inhibitor of Activated STATx Proteins

2005 • 19 citations

Functional analyses of an LXXLL motif in nuclear receptor corepressor (N-CoR)

2004 • 13 citations

Negative regulation of Smad2 by PIASy is required for properXenopusmesoderm formation

2004 • 11 citations