Proteins of the PIAS family enhance the sumoylation of the papillomavirus E1 protein

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

SUMO-1 Modification of IκBα Inhibits NF-κB Activation

1998 • 1,002 citations

The Nucleoporin RanBP2 Has SUMO1 E3 Ligase Activity

2002 • 787 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting

2001 • 722 citations

Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus

1998 • 676 citations

An E3-like Factor that Promotes SUMO Conjugation to the Yeast Septins

2001 • 642 citations

The Polycomb Protein Pc2 Is a SUMO E3

2003 • 558 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region

1995 • 471 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

SUMO-1 Modification and Its Role in Targeting the Ran GTPase-activating Protein, RanGAP1, to the Nuclear Pore Complex

1998 • 455 citations

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53

2001 • 447 citations

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

2002 • 441 citations

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

2002 • 420 citations

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

2000 • 394 citations

Identification of the Enzyme Required for Activation of the Small Ubiquitin-like Protein SUMO-1

1999 • 353 citations

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

2002 • 316 citations

Phosphorylation of Serine 303 Is a Prerequisite for the Stress-Inducible SUMO Modification of Heat Shock Factor 1

2003 • 304 citations

Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment

1998 • 269 citations

Transcription factor Sp3 is silenced through SUMO modification by PIAS1

2002 • 261 citations

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

2001 • 242 citations

In VitroSUMO-1 Modification Requires Two Enzymatic Steps, E1 and E2

1999 • 224 citations

PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription

2002 • 208 citations

The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein import

2002 • 199 citations

Transcriptional Activity of Peroxisome Proliferator-activated Receptor γ Is Modulated by SUMO-1 Modification

2004 • 180 citations

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

2003 • 173 citations

ARIP3 (Androgen Receptor-Interacting Protein 3) and Other PIAS (Protein Inhibitor of Activated STAT) Proteins Differ in Their Ability to Modulate Steroid Receptor-Dependent Transcriptional Activation

2000 • 171 citations

SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation

2003 • 166 citations

Versatile protein tag, SUMO: Its enzymology and biological function

2002 • 163 citations

A Synergy Control Motif within the Attenuator Domain of CCAAT/Enhancer-binding Protein α Inhibits Transcriptional Synergy through Its PIASy-enhanced Modification by SUMO-1 or SUMO-3

2003 • 153 citations

PIAS proteins promote SUMO-1 conjugation to STAT1

2003 • 150 citations

Papillomavirus E1 proteins: form, function, and features.

2002 • 146 citations

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

2000 • 133 citations

Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication

1999 • 133 citations

Human Papillomavirus DNA Replication

1999 • 121 citations

Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4

2003 • 120 citations

Protein Inhibitor of Activated Signal Transducer and Activator of Transcription 1 Interacts with the N-Terminal Domain of Mineralocorticoid Receptor and Represses Its Transcriptional Activity: Implication of Small Ubiquitin-Related Modifier 1 Modification

2003 • 115 citations

Cellular factors required for papillomavirus DNA replication

1995 • 105 citations

PIAS3 induces SUMO‐1 modification and transcriptional repression of IRF‐1

2002 • 103 citations

Intracellular Targeting of Proteins by Sumoylation

2001 • 102 citations

Sumoylation of Mdm2 by Protein Inhibitor of Activated STAT (PIAS) and RanBP2 Enzymes

2002 • 97 citations

Role of the ATP-Binding Domain of the Human Papillomavirus Type 11 E1 Helicase in E2-Dependent Binding to the Origin

1999 • 91 citations

Regulation of Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT, PIASy through Smad3

2003 • 84 citations

SUMO-1 Modification of the C-terminal KVEKVD of Axin Is Required for JNK Activation but Has No Effect on Wnt Signaling

2002 • 83 citations

SUMO-1 Modification of Bovine Papillomavirus E1 Protein Is Required for Intranuclear Accumulation

2000 • 82 citations

Bovine papillomavirus E1 protein binds specifically DNA polymerase alpha but not replication protein A

1995 • 74 citations

Transactivation properties of c‐Myb are critically dependent on two SUMO‐1 acceptor sites that are conjugated in a PIASy enhanced manner

2003 • 71 citations

The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site

1993 • 66 citations

Bovine Papillomavirus E1 Protein Is Sumoylated by the Host Cell Ubc9 Protein

2000 • 64 citations

SUMO-1 Modification of Human Cytomegalovirus IE1/IE72

2002 • 61 citations

MBP1: a novel mutant p53-specific protein partner with oncogenic properties

1999 • 59 citations

Functional Interaction between the Bovine Papillomavirus Virus Type 1 Replicative Helicase E1 and Cyclin E-Cdk2

1998 • 47 citations

Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification

2003 • 45 citations

Identification of Domains of the HPV11 E1 Protein Required for DNA Replication in Vitro

2000 • 44 citations

Bovine papillomavirus E1 protein can, by itself, efficiently drive multiple rounds of DNA synthesis in vitro

1995 • 39 citations

Isolation of an amino-terminal region of bovine papillomavirus type 1 E1 protein that retains origin binding and E2 interaction capacity

1997 • 38 citations

Repression of the Transactivating Capacity of the Oncoprotein PLAG1 by SUMOylation

2004 • 37 citations

The SUMO Ubiquitin-Protein Isopeptide Ligase Family Member Miz1/PIASxβ/Siz2 Is a Transcriptional Cofactor for TFII-I

2002 • 31 citations

Modulation of Bovine Papillomavirus DNA Replication by Phosphorylation of the Viral E1 Protein

1997 • 28 citations

Identification of a Short, Hydrophilic Amino Acid Sequence Critical for Origin Recognition by the Bovine Papillomavirus E1 Protein

2000 • 26 citations

Regulation of Bovine Papillomavirus Replicative Helicase E1 by the Ubiquitin-Proteasome Pathway

2002 • 23 citations

A New Clue at the Nuclear Pore

2002 • 22 citations

Casein kinase II phosphorylates bovine papillomavirus type 1 E1 in vitro at a conserved motif.

1997 • 21 citations

Interaction of the developmental regulator SALL1 with UBE2I and SUMO-1

2002 • 19 citations

Genetically defined nuclear localization signal sequence of bovine papillomavirus E1 protein is necessary and sufficient for the nuclear localization of E1-beta-galactosidase fusion proteins

1994 • 19 citations

A carboxyl-terminal serine of the bovine papillomavirus E1 protein is phosphorylated in vivo and in vitro

2002 • 14 citations