Regulation of Transforming Growth Factor-β Signaling by Protein Inhibitor of Activated STAT, PIASy through Smad3

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad7 Binds to Smurf2 to Form an E3 Ubiquitin Ligase that Targets the TGFβ Receptor for Degradation

2000 • 1,299 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

Smurf1 Interacts with Transforming Growth Factor-β Type I Receptor through Smad7 and Induces Receptor Degradation

2001 • 828 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

SUMO—Nonclassical Ubiquitin

2000 • 764 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation

1998 • 527 citations

Role of Transforming Growth Factor-beta Signaling in Cancer

2000 • 525 citations

TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300

1998 • 503 citations

Divergence and convergence of TGF‐β/BMP signaling

2001 • 503 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA.

2000 • 455 citations

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53

2001 • 447 citations

A mechanism of suppression of TGF–β/SMAD signaling by NF-κB/RelA

2000 • 397 citations

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads

1999 • 380 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function

1997 • 317 citations

DJ-1 Positively Regulates the Androgen Receptor by Impairing the Binding of PIASxα to the Receptor

2001 • 312 citations

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

1999 • 252 citations

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

2001 • 242 citations

Disruption of Transforming Growth Factor β Signaling by a Mutation That Prevents Transphosphorylation within the Receptor Complex

1995 • 217 citations

Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-β/Smad signaling

2002 • 205 citations

Ski acts as a co-repressor with Smad2 and Smad3 to regulate the response to type β transforming growth factor

2000 • 187 citations

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

2003 • 173 citations

ARIP3 (Androgen Receptor-Interacting Protein 3) and Other PIAS (Protein Inhibitor of Activated STAT) Proteins Differ in Their Ability to Modulate Steroid Receptor-Dependent Transcriptional Activation

2000 • 171 citations

STRAP and Smad7 Synergize in the Inhibition of Transforming Growth Factor β Signaling

2000 • 171 citations

Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells

2001 • 167 citations

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFb-dependent phosphorylation

2000 • 165 citations

Role of p300, a transcriptional coactivator, in signalling of TGF‐β

1998 • 162 citations

Activation of Transforming Growth Factor-β Signaling by SUMO-1 Modification of Tumor Suppressor Smad4/DPC4

2003 • 129 citations

Differential Ubiquitination Defines the Functional Status of the Tumor Suppressor Smad4

2003 • 97 citations

Protein Inhibitor of Activated STAT3 Regulates Androgen Receptor Signaling in Prostate Carcinoma Cells

2000 • 81 citations

Activation of Estrogen Receptor Blocks Interleukin-6-inducible Cell Growth of Human Multiple Myeloma Involving Molecular Cross-talk between Estrogen Receptor and STAT3 Mediated by Co-regulator PIAS3

2001 • 80 citations

A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis.

2001 • 67 citations

Cross‐talk between IL‐6 and TGF‐β signaling in hepatoma cells

2001 • 66 citations

SOCS‐1 can suppress CD3ζ‐ and Syk‐mediated NF‐AT activation in a non‐lymphoid cell line

2000 • 57 citations

Restoration of TGF-β regulation of plasminogen activator inhibitor-1 in Smad3-restituted human choriocarcinoma cells

2002 • 23 citations