Incredible journey: how do developmental signals travel through tissue?

The chemical basis of morphogenesis

1952 • 11,233 citations

What Is Life

1944 • 2,479 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

The Cell in Development and Heredity

1925 • 1,750 citations

The segment polarity network is a robust developmental module

2000 • 1,177 citations

Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

2004 • 970 citations

Direct and Long-Range Action of a DPP Morphogen Gradient

1996 • 896 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Patched acts catalytically to suppress the activity of Smoothened

2002 • 784 citations

Direct and Long-Range Action of a Wingless Morphogen Gradient

1996 • 736 citations

Gradient Formation of the TGF-β Homolog Dpp

2000 • 606 citations

Cytonemes

1999 • 602 citations

Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells

1999 • 571 citations

Hedgehog Patterning Activity: Role of a Lipophilic Modification Mediated by the Carboxy-Terminal Autoprocessing Domain

1996 • 529 citations

Identification of Hedgehog Pathway Components by RNAi in Drosophila Cultured Cells

2003 • 518 citations

Cholesterol Modification of Sonic Hedgehog Is Required for Long-Range Signaling Activity and Effective Modulation of Signaling by Ptc1

2001 • 514 citations

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 • 514 citations

Tout-velu is a Drosophila homologue of the putative tumour suppressor EXT-1 and is needed for Hh diffusion

1998 • 505 citations

Dynamic Changes in the Response of Cells to Positive Hedgehog Signaling during Mouse Limb Patterning

2004 • 498 citations

A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 • 485 citations

Dpp Gradient Formation in the Drosophila Wing Imaginal Disc

2000 • 453 citations

Morphogens, their identification and regulation

2004 • 437 citations

Wingless gradient formation in the Drosophila wing

2000 • 437 citations

Hrs Regulates Endosome Membrane Invagination and Tyrosine Kinase Receptor Signaling in Drosophila

2002 • 431 citations

fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo

2004 • 420 citations

Argosomes

2001 • 413 citations

Do Morphogen Gradients Arise by Diffusion?

2002 • 403 citations

Hedgehog Creates a Gradient of DPP Activity in Drosophila Wing Imaginal Discs

2000 • 402 citations

Cleavage of Chordin by Xolloid Metalloprotease Suggests a Role for Proteolytic Processing in the Regulation of Spemann Organizer Activity

1997 • 398 citations

Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless

2001 • 370 citations

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

1999 • 367 citations

Hedgehog Movement Is Regulated through tout velu–Dependent Synthesis of a Heparan Sulfate Proteoglycan

1999 • 367 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

Glypicans: proteoglycans with a surprise

2001 • 360 citations

Production of a DPP Activity Gradient in the Early Drosophila Embryo through the Opposing Actions of the SOG and TLD Proteins

1997 • 350 citations

Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface

2003 • 339 citations

Glypicans: proteoglycans with a surprise

2001 • 337 citations

Wingless Repression of Drosophila frizzled 2 Expression Shapes the Wingless Morphogen Gradient in the Wing

1998 • 331 citations

The zebrafish Nodal signal Squint functions as a morphogen

2001 • 328 citations

Activin signalling and response to a morphogen gradient

1994 • 328 citations

Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched

2002 • 327 citations

Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4

2003 • 316 citations

Relationship between dose, distance and time in Sonic Hedgehog-mediated regulation of anteroposterior polarity in the chick limb

1997 • 314 citations

Drosophila Dpp Morphogen Movement Is Independent of Dynamin-Mediated Endocytosis but Regulated by the Glypican Members of Heparan Sulfate Proteoglycans

2004 • 297 citations

Self-Enhanced Ligand Degradation Underlies Robustness of Morphogen Gradients

2003 • 292 citations

The Drosophila sugarless gene modulates Wingless signaling and encodes an enzyme involved in polysaccharide biosynthesis

1997 • 290 citations

The Whereabouts of a Morphogen: Direct Evidence for Short- and Graded Long-Range Activity of Hedgehog Signaling Peptides

2001 • 288 citations

ThreeDrosophilaEXT genes shape morphogen gradients through synthesis of heparan sulfate proteoglycans

2003 • 274 citations

A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord

2002 • 257 citations

Genetic evidence that heparin-like glycosaminoglycans are involved in wingless signaling

1997 • 257 citations

Hedgehog, Transmitted along Retinal Axons, Triggers Neurogenesis in the Developing Visual Centers of the Drosophila Brain

1996 • 255 citations

In Vivo Transfer of GPI-Linked Complement Restriction Factors from Erythrocytes to the Endothelium

1995 • 254 citations

ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling

2003 • 241 citations

HSPG Modification by the Secreted Enzyme Notum Shapes the Wingless Morphogen Gradient

2002 • 238 citations

Drosophilaglypicans control the cell-to-cell movement of Hedgehog by a dynamin-independent process

2004 • 237 citations

Distinct and collaborative roles ofDrosophilaEXT family proteins in morphogen signalling and gradient formation

2004 • 228 citations

Dally regulates Dpp morphogen gradient formation in theDrosophilawing

2003 • 223 citations

Abrogation of heparan sulfate synthesis inDrosophiladisrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways

2004 • 221 citations

Regulated Endocytic Routing Modulates Wingless Signaling in Drosophila Embryos

2001 • 211 citations

The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors

1998 • 205 citations

Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc

1998 • 202 citations

Defects in glucuronate biosynthesis disrupt Wingless signaling in Drosophila

1997 • 196 citations

Topology and Robustness in the Drosophila Segment Polarity Network

2004 • 192 citations

Sonic Hedgehog Induces the Segregation of Patched and Smoothened in Endosomes

2002 • 189 citations

The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking

2001 • 183 citations

Delta-promoted filopodia mediate long-range lateral inhibition in Drosophila

2003 • 181 citations

Mechanisms for Positional Signalling by Morphogen Transport: a Theoretical Study

1998 • 181 citations

Cholesterol Modification of Hedgehog Is Required for Trafficking and Movement, Revealing an Asymmetric Cellular Response to Hedgehog

2003 • 180 citations

Drosophila Segment Polarity Gene Product Porcupine Stimulates the Posttranslational N-Glycosylation of Wingless in the Endoplasmic Reticulum

2002 • 172 citations

Patched controls the Hedgehog gradient by endocytosis in a dynamin-dependent manner, but this internalization does not play a major role in signal transduction

2004 • 165 citations

Signal dispersal and transduction through the endocytic pathway

2003 • 144 citations

Hrs mediates downregulation of multiple signalling receptors in Drosophila

2003 • 143 citations

The glypican Dally-like is required for Hedgehog signalling in the embryonic epidermis ofDrosophila

2003 • 142 citations

In Vivo Functions of the Patched Protein

2000 • 128 citations

Apical Localization of wingless Transcripts Is Required for Wingless Signaling

2001 • 125 citations

Wingful, an extracellular feedback inhibitor of Wingless

2002 • 121 citations

An Acylatable Residue of Hedgehog Is Differentially Required in Drosophila and Mouse Limb Development

2001 • 120 citations

act up Controls Actin Polymerization to Alter Cell Shape and Restrict Hedgehog Signaling in the Drosophila Eye Disc

2000 • 120 citations

N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons

2001 • 119 citations

Reading the Hedgehog morphogen gradient by measuring the ratio of bound to unbound Patched protein

2004 • 109 citations

Physical properties of Tld, Sog, Tsg and Dpp protein interactions are predicted to help create a sharp boundary in Bmp signals during dorsoventral patterning of theDrosophilaembryo

2003 • 109 citations

Creation of a Sog Morphogen Gradient in the Drosophila Embryo

2002 • 108 citations

Cells’ Perception of Position in a Concentration Gradient

1998 • 107 citations

The progeny of wingless-expressing cells deliver the signal at a distance in Drosophila embryos

2000 • 87 citations

Morphogen Transport along Epithelia, an Integrated Trafficking Problem

2002 • 82 citations

Short- and long-range effects of Sonic hedgehog in limb development

2003 • 64 citations

Modulation of developmental signals by endocytosis: different means and many ends

2003 • 54 citations

Formation of a functional morphogen gradient by a passive process in tissue from the early Xenopus embryo.

2001 • 49 citations

Integrins modulate Sog activity in theDrosophilawing

2003 • 34 citations

Dose dependency ofDisp1and genetic interaction betweenDisp1and other hedgehog signaling components in the mouse

2004 • 28 citations

Wingless Capture by Frizzled and Frizzled2 in Drosophila Embryos

2001 • 24 citations

Functional analysis in Drosophila indicates that the NBCCS/PTCH1 mutation G509V results in activation of smoothened through a dominant‐negative mechanism

2004 • 23 citations

Green fluorescent protein as a tool to study epidermal growth factor receptor function

2003 • 15 citations

[Role of apoptosis in age-related pathologies].

2001 • 8 citations