Smads as transcriptional co-modulators

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Transcriptional Activators of TGF-β Responses: Smads

1998 • 1,024 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor

1998 • 952 citations

Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators

1998 • 916 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

1997 • 867 citations

Synergistic Signaling in Fetal Brain by STAT3-Smad1 Complex Bridged by p300

1999 • 841 citations

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1999 • 833 citations

Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway

1999 • 800 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Crystal Structure of a Smad MH1 Domain Bound to DNA

1998 • 709 citations

A transcriptional partner for MAD proteins in TGF-β signalling

1996 • 699 citations

A human Mad protein acting as a BMP-regulated transcriptional activator

1996 • 674 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Smad4 and FAST-1 in the assembly of activin-responsive factor

1997 • 567 citations

A Smad Transcriptional Corepressor

1999 • 563 citations

Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic

1997 • 524 citations

Smad2 and Smad3 Positively and Negatively Regulate TGFβ-Dependent Transcription through the Forkhead DNA-Binding Protein FAST2

1998 • 513 citations

Negative Feedback Regulation of TGF-β Signaling by the SnoN Oncoprotein

1999 • 498 citations

SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes

1999 • 492 citations

The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling

1999 • 471 citations

A structural basis for mutational inactivation of the tumour suppressor Smad4

1997 • 459 citations

Interaction and Functional Cooperation of PEBP2/CBF with Smads

1999 • 449 citations

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

1999 • 442 citations

Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression

1999 • 441 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

OAZ Uses Distinct DNA- and Protein-Binding Zinc Fingers in Separate BMP-Smad and Olf Signaling Pathways

2000 • 428 citations

c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads

1999 • 380 citations

The oncoprotein Evi-1 represses TGF-β signalling by inhibiting Smad3

1998 • 369 citations

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4

1997 • 365 citations

Determinants of specificity in TGF-β signal transduction

1998 • 364 citations

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.

1996 • 351 citations

ATF-2 Is a Common Nuclear Target of Smad and TAK1 Pathways in Transforming Growth Factor-β Signaling

1999 • 347 citations

Ubiquitin-dependent degradation of TGF-β-activated Smad2

1999 • 343 citations

Smads bind directly to the Jun family of AP-1 transcription factors

1999 • 324 citations

Structural Basis of Smad2 Recognition by the Smad Anchor for Receptor Activation

2000 • 291 citations

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

1998 • 281 citations

Microtubule Binding to Smads May Regulate TGFβ Activity

2000 • 277 citations

Interaction of the Ski Oncoprotein with Smad3 Regulates TGF-β Signaling

1999 • 265 citations

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors

1998 • 265 citations

SnoN and Ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling

1999 • 252 citations

Transforming Growth Factor β1 Induces Nuclear Export of Inhibitory Smad7

1998 • 240 citations

Alternatively Spliced Variant of Smad2 Lacking Exon 3

1999 • 235 citations

Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer

1998 • 230 citations

Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-β Family Receptors

1999 • 219 citations

A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity

1997 • 203 citations

Mads and Smads in TGFβ signalling

1998 • 194 citations

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway

2000 • 192 citations

The Drosophila Activin receptor Baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development

1999 • 190 citations

Smad1 Interacts with Homeobox DNA-binding Proteins in Bone Morphogenetic Protein Signaling

1999 • 187 citations

Specificity in transforming growth factor β-induced transcription of the plasminogen activator inhibitor-1 gene: Interactions of promoter DNA, transcription factor μE3, and Smad proteins

1999 • 155 citations

Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator

1998 • 139 citations

A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction

1997 • 129 citations

The Role of FAST-1 and Smads in Transcriptional Regulation by Activin during Early Xenopus Embryogenesis

1999 • 111 citations

FAST-2 Is a Mammalian Winged-Helix Protein Which Mediates Transforming Growth Factor β Signals

1999 • 88 citations

Interaction of Smad Complexes with Tripartite DNA-binding Sites

1999 • 87 citations

Smad7 Differentially Regulates Transforming Growth Factor β-mediated Signaling Pathways

1999 • 87 citations

A mouse homologue of FAST-1 transduces TGFβ superfamily signals and is expressed during early embryogenesis

1998 • 81 citations

Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-β family signals

1999 • 56 citations