SUMO Modification of STAT1 and Its Role in PIAS-mediated Inhibition of Gene Activation

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Signaling through the JAK/STAT pathway, recent advances and future challenges

2002 • 1,132 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

SUMO—Nonclassical Ubiquitin

2000 • 764 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting

2001 • 722 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

An E3-like Factor that Promotes SUMO Conjugation to the Yeast Septins

2001 • 642 citations

Structural Basis for E2-Mediated SUMO Conjugation Revealed by a Complex between Ubiquitin-Conjugating Enzyme Ubc9 and RanGAP1

2002 • 562 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

The Small Ubiquitin-like Modifier-1 (SUMO-1) Consensus Sequence Mediates Ubc9 Binding and Is Essential for SUMO-1 Modification

2001 • 506 citations

Identification of a Nuclear Stat1 Protein Tyrosine Phosphatase

2002 • 482 citations

Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 (SUMO-1)

2000 • 448 citations

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53

2001 • 447 citations

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

2002 • 441 citations

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

2002 • 420 citations

The Role of STATs in Apoptosis

2002 • 275 citations

Transcription factor Sp3 is silenced through SUMO modification by PIAS1

2002 • 261 citations

A Common Motif within the Negative Regulatory Regions of Multiple Factors Inhibits Their Transcriptional Synergy

2000 • 222 citations

PIAS1 and PIASxα Function as SUMO-E3 Ligases toward Androgen Receptor and Repress Androgen Receptor-dependent Transcription

2002 • 208 citations

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

2001 • 198 citations

Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein binds.

1993 • 154 citations

A Synergy Control Motif within the Attenuator Domain of CCAAT/Enhancer-binding Protein α Inhibits Transcriptional Synergy through Its PIASy-enhanced Modification by SUMO-1 or SUMO-3

2003 • 153 citations

Potentiation of Glucocorticoid Receptor Transcriptional Activity by Sumoylation

2002 • 152 citations

Sumoylation of the Progesterone Receptor and of the Steroid Receptor Coactivator SRC-1

2003 • 138 citations

Signal transduction in the interferon system.

1998 • 124 citations

Distinct roles of the NH ₂ - and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1–Stat1 interaction

2000 • 119 citations

Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development

2000 • 113 citations

PIAS3 induces SUMO‐1 modification and transcriptional repression of IRF‐1

2002 • 103 citations

Activation of the Jak2-Stat5 Signaling Pathway in Nb2 Lymphoma Cells by an Anti-apoptotic Agent, Aurintricarboxylic Acid

1998 • 79 citations

Androgen Receptor-interacting Protein 3 and Other PIAS Proteins Cooperate with Glucocorticoid Receptor-interacting Protein 1 in Steroid Receptor-dependent Signaling

2002 • 63 citations