Interplay between MITF, PIAS3, and STAT3 in Mast Cells and Melanocytes

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stat3 as an Oncogene

1999 • 2,770 citations

STATs in oncogenesis

2000 • 1,723 citations

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

1997 • 1,306 citations

Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors

2000 • 1,150 citations

Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein

1993 • 1,083 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

Bcl2 Regulation by the Melanocyte Master Regulator Mitf Modulates Lineage Survival and Melanoma Cell Viability

2002 • 728 citations

MAP kinase links the transcription factor Microphthalmia to c-Kit signalling in melanocytes

1998 • 617 citations

Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesisin vivo

2000 • 594 citations

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi

2000 • 517 citations

Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis

2001 • 487 citations

Early signaling pathways activated by c-Kit in hematopoietic cells

1999 • 385 citations

Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling

2000 • 295 citations

A helix-loop-helix transcription factor-like gene is located at the mi locus.

1993 • 253 citations

Ectopic expression of MITF, a gene for Waardenburg syndrome type 2, converts fibroblasts to cells with melanocyte characteristics

1996 • 252 citations

Dominant Negative Stat3 Mutant Inhibits Interleukin-6-induced Jak-STAT Signal Transduction

1996 • 243 citations

A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases

2001 • 242 citations

Growth of a pure population of mouse mast cells in vitro with conditioned medium derived from concanavalin A-stimulated splenocytes.

1981 • 238 citations

Insight into the microphthalmia gene

1995 • 216 citations

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

2001 • 198 citations

Effects of T-helper 2-type cytokines, interleukin-3 (IL-3), IL-4, IL-5, and IL-6 on the survival of cultured human mast cells

1995 • 179 citations

Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells

2001 • 167 citations

Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance

2000 • 160 citations

Linkage of M-CSF Signaling to Mitf, TFE3, and the Osteoclast Defect in Mitfmi/mi Mice

2001 • 155 citations

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

2003 • 145 citations

The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3

2000 • 133 citations

Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus

1996 • 133 citations

Common structural changes accompany the functional inactivation of HPr by seryl phosphorylation or by serine to aspartate substitution

1989 • 111 citations

Genomic, Transcriptional and Mutational Analysis of the Mouse microphthalmia Locus

2000 • 105 citations

Suppression of Microphthalmia Transcriptional Activity by Its Association with Protein Kinase C-interacting Protein 1 in Mast Cells

1999 • 96 citations

A New Role for the STAT3 Inhibitor, PIAS3

2002 • 91 citations

Abnormal Expression of Mouse Mast Cell Protease 5 Gene in Cultured Mast Cells Derived From Mutant mi/mi Mice

1997 • 87 citations

Age-resolving Osteopetrosis: A Rat Model Implicating Microphthalmia and the Related Transcription Factor TFE3

1998 • 85 citations

The ‘PINIT’ motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L

2003 • 84 citations

Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.

1994 • 69 citations

Pax3 Down-regulation and Shut-off of Melanogenesis in Melanoma B16/F10.9 by Interleukin-6 Receptor Signaling

2002 • 68 citations

Protection From Apoptosis by Steel Factor But Not Interleukin-3 Is Reversed Through Blockade of Calcium Influx

1998 • 58 citations

Inhibitory Effect of the Transcription Factor Encoded by themi Mutant Allele in Cultured Mast Cells of Mice

1999 • 56 citations

Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho

1999 • 56 citations

The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice

2001 • 46 citations

Microphthalmia transcription factor

2001 • 46 citations

Role Played by Microphthalmia Transcription Factor Phosphorylation and Its Zip Domain in Its Transcriptional Inhibition by PIAS3

2003 • 41 citations

Effect of Anatomical Distribution of Mast Cells on Their Defense Function against Bacterial Infections

2003 • 40 citations

Effect of MITF on mast cell differentiation

2002 • 38 citations

Effect of a large deletion of the basic domain of mitranscription factor on differentiation of mast cells

2001 • 24 citations

Activation of c-Jun transcription factor by substitution of a charged residue in its N-terminal domain

1994 • 16 citations