p73, the “Assistant” Guardian of the Genome?

Surfing the p53 network

2000 • 6,487 citations

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

Cell Cycle Control and Cancer

1994 • 2,575 citations

p63, a p53 Homolog at 3q27–29, Encodes Multiple Products with Transactivating, Death-Inducing, and Dominant-Negative Activities

1998 • 2,061 citations

Cell Cycle Checkpoints: Preventing an Identity Crisis

1996 • 2,056 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Monoallelically Expressed Gene Related to p53 at 1p36, a Region Frequently Deleted in Neuroblastoma and Other Human Cancers

1997 • 1,636 citations

Quality Control by DNA Repair

1999 • 1,469 citations

Human DNA Repair Genes

2001 • 1,451 citations

Decision making by p53: life, death and cancer

2003 • 1,055 citations

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

2002 • 982 citations

p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

2000 • 979 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Akt Phosphorylates the Yes-Associated Protein, YAP, to Induce Interaction with 14-3-3 and Attenuation of p73-Mediated Apoptosis

2003 • 805 citations

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

2002 • 803 citations

Role for the p53 homologue p73 in E2F-1-induced apoptosis

2000 • 700 citations

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

2001 • 656 citations

p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

1999 • 584 citations

MDM2–HDAC1-mediated deacetylation of p53 is required for its degradation

2002 • 554 citations

p73: Friend or foe in tumorigenesis

2002 • 546 citations

Interaction of c-Abl and p73α and their collaboration to induce apoptosis

1999 • 542 citations

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

2000 • 514 citations

On the shoulders of giants: p63, p73 and the rise of p53

2002 • 485 citations

An Anti-Apoptotic Role for the p53 Family Member, p73, During Developmental Neuron Death

2000 • 461 citations

Ex vivo expansion, adipogenesis and neurogenesis of cryopreserved human bone marrow mesenchymal stem cells

2006 • 426 citations

The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults

2002 • 412 citations

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

2002 • 381 citations

Two New p73 Splice Variants, γ and δ, with Different Transcriptional Activity

1998 • 363 citations

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

2002 • 346 citations

Parc

2003 • 346 citations

Human ΔNp73 regulates a dominant negative feedback loop for TAp73 and p53

2001 • 335 citations

ΔNp73, A Dominant-Negative Inhibitor of Wild-type p53 and TAp73, Is Up-regulated in Human Tumors

2002 • 317 citations

Functional regulation of p73 and p63: development and cancer

2003 • 278 citations

Regulation of p53 responses by post-translational modifications

2003 • 265 citations

Transcriptional repression mediated by the p53 tumour suppressor

2003 • 199 citations

Induction of Neuronal Differentiation by p73 in a Neuroblastoma Cell Line

2000 • 184 citations

Expression of ΔNp73 is a molecular marker for adverse outcome in neuroblastoma patients

2002 • 179 citations

p73 Is Required for Survival and Maintenance of CNS Neurons

2002 • 144 citations

Transactivation-deficient p73α (p73Δexon2) inhibits apoptosis and competes with p53

2001 • 121 citations

Regulation of p73 by c-Abl through the p38 MAP kinase pathway

2002 • 109 citations

Nitric oxide promotes p53 nuclear retention and sensitizes neuroblastoma cells to apoptosis by ionizing radiation

2003 • 103 citations

p53 Activation by Nitric Oxide Involves Down-regulation of Mdm2

2002 • 85 citations

Nitric Oxide-Mediated Inhibition of Hdm2−p53 Binding

2002 • 61 citations

The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21CIP1/Waf1

2002 • 54 citations

Renewing the debate over the p53 apoptotic response

2003 • 27 citations

Mouse models with modified p53 sequences to study cancer and ageing

2003 • 17 citations