P53 and Prognosis

Surfing the p53 network

2000 • 6,487 citations

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

2004 • 4,416 citations

p53 mutant mice that display early ageing-associated phenotypes

2002 • 1,428 citations

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

2003 • 1,266 citations

Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome

2004 • 1,249 citations

A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

2004 • 1,241 citations

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound

2002 • 1,025 citations

Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome

2004 • 1,016 citations

The p53–Mdm2 module and the ubiquitin system

2002 • 759 citations

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

2000 • 663 citations

Modulation of mammalian life span by the short isoform of p53

2004 • 564 citations

A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

2000 • 514 citations

Chemosensitivity linked to p73 function

2003 • 404 citations

mdm2 Is Critical for Inhibition of p53 during Lymphopoiesis and the Response to Ionizing Irradiation

2003 • 234 citations

The effects of wild-type p53 tumor suppressor activity and mutant p53 gain-of-function on cell growth

2001 • 224 citations

p53-independent functions of MDM2.

2003 • 148 citations

Mutant p53 gain of function: repression of CD95(Fas/APO-1) gene expression by tumor-associated p53 mutants

2003 • 127 citations

p53, p63 and p73 – solos, alliances and feuds among family members

2001 • 116 citations