Negative Regulation of NF-κB Signaling by PIAS1

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

Regulation of JAK–STAT signalling in the immune system

2003 • 1,313 citations

How NF-κB is activated: the role of the IκB kinase (IKK) complex

1999 • 1,133 citations

Specific Inhibition of Stat3 Signal Transduction by PIAS3

1997 • 971 citations

IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program

2002 • 844 citations

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

1993 • 797 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

NF-kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules.

1997 • 576 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice.

1995 • 477 citations

NF-κB as a Frequent Target for Immunosuppressive and Anti-Inflammatory Molecules**This article was accepted for publication on 27 September 1996.

1997 • 472 citations

Involvement of PIAS1 in the Sumoylation of Tumor Suppressor p53

2001 • 447 citations

Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

2002 • 441 citations

Twist Regulates Cytokine Gene Expression through a Negative Feedback Loop that Represses NF-κB Activity

2003 • 439 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Involvement of receptor-interacting protein 2 in innate and adaptive immune responses

2002 • 395 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity

2004 • 256 citations

Efficient adenoviral infection with IκBα reveals that macrophage tumor necrosis factor α production in rheumatoid arthritis is NF-κB dependent

1998 • 251 citations

An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity

2000 • 249 citations

NF-kB: a pivotal role in asthma and a new target for therapy

1997 • 218 citations

Mice Lacking the Orphan G Protein-Coupled Receptor G2A Develop a Late-Onset Autoimmune Syndrome

2001 • 204 citations

A transcriptional corepressor of Stat1 with an essential LXXLL signature motif

2001 • 198 citations

Identification of NF-κB-regulated genes induced by TNFα utilizing expression profiling and RNA interference

2003 • 174 citations

Distinct effects of PIAS proteins on androgen-mediated gene activation in prostate cancer cells

2001 • 167 citations

Convergence of TNF and IFN signalling pathways through synergistic induction of IRF-1/ISGF-2 is mediated by a composite GAS/ B promoter element

1997 • 165 citations

A Testis-specific Androgen Receptor Coregulator That Belongs to a Novel Family of Nuclear Proteins

1999 • 158 citations

PIASx Is a Transcriptional Co-repressor of Signal Transducer and Activator of Transcription 4

2003 • 121 citations

PIAS3 Suppresses NF-κB-mediated Transcription by Interacting with the p65/RelA Subunit

2004 • 96 citations

Protein Inhibitor of Activated STAT-1 (Signal Transducer and Activator of Transcription-1) Is a Nuclear Receptor Coregulator Expressed in Human Testis

2000 • 94 citations

Activation of p53 by Protein Inhibitor of Activated Stat1 (PIAS1)

2002 • 88 citations

Protein Inhibitors of Activated STAT Resemble Scaffold Attachment Factors and Function as Interacting Nuclear Receptor Coregulators

2002 • 81 citations

Induction of IP-10 chemokine promoter by measles virus: comparison with interferon-γ shows the use of the same response element but with differential DNA–protein binding profiles

1997 • 57 citations

Induction of Apoptosis by Protein Inhibitor of Activated Stat1 through c-Jun NH2-terminal Kinase Activation

2001 • 42 citations