Protein tyrosine phosphatases: from genes, to function, to disease

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

Cellular signaling by fibroblast growth factor receptors

2005 • 1,873 citations

Protein Tyrosine Phosphatases in the Human Genome

2004 • 1,842 citations

Reactive Oxygen Species Promote TNFα-Induced Death and Sustained JNK Activation by Inhibiting MAP Kinase Phosphatases

2005 • 1,727 citations

A Missense Single-Nucleotide Polymorphism in a Gene Encoding a Protein Tyrosine Phosphatase (PTPN22) Is Associated with Rheumatoid Arthritis

2004 • 1,489 citations

A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes

2004 • 1,392 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

2006 • 1,210 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

2002 • 1,020 citations

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2003 • 1,019 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

CD45: A Critical Regulator of Signaling Thresholds in Immune Cells

2003 • 849 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

LKB1-Dependent Signaling Pathways

2006 • 762 citations

Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

2005 • 752 citations

Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant

2005 • 707 citations

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

2005 • 702 citations

Redox Redux: Revisiting PTPs and the Control of Cell Signaling

2005 • 696 citations

Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

2001 • 694 citations

Intracellular Signaling by Reactive Oxygen Species during Hypoxia in Cardiomyocytes

1998 • 684 citations

Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE

2004 • 665 citations

Protein-tyrosine phosphatases and cancer

2006 • 638 citations

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

2003 • 627 citations

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

2004 • 605 citations

Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance

2005 • 537 citations

Mathematical Models of Protein Kinase Signal Transduction

2002 • 525 citations

Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers

2004 • 517 citations

Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade

2001 • 511 citations

Redox-dependent downregulation of Rho by Rac

2003 • 508 citations

Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

2004 • 496 citations

Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

2004 • 489 citations

Allosteric inhibition of protein tyrosine phosphatase 1B

2004 • 488 citations

Switching Signals On or Off by Receptor Dimerization

1998 • 428 citations

Reactive oxygen species as essential mediators of cell adhesion

2003 • 427 citations

Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ

2000 • 415 citations

Grouping of Multiple-Lentigines/LEOPARD and Noonan Syndromes on the PTPN11 Gene

2002 • 409 citations

PTP1B antisense oligonucleotide lowers PTP1B protein, normalizes blood glucose, and improves insulin sensitivity in diabetic mice

2002 • 407 citations

A Tyr/Ser protein phosphatase encoded by vaccinia virus

1991 • 403 citations

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.

1990 • 365 citations

NOONAN SYNDROME AND RELATED DISORDERS: Genetics and Pathogenesis

2005 • 346 citations

Structural basis for inhibition of receptor protein-tyrosine phosphatase-α by dimerization

1996 • 324 citations

PTPN11 (Shp2) Mutations in LEOPARD Syndrome Have Dominant Negative, Not Activating, Effects

2005 • 314 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage

2004 • 307 citations

Cdc25 Phosphatases and Cancer

2004 • 300 citations

Mutations in MTMR13, a New Pseudophosphatase Homologue of MTMR2 and Sbf1, in Two Families with an Autosomal Recessive Demyelinating Form of Charcot-Marie-Tooth Disease Associated with Early-Onset Glaucoma

2003 • 296 citations

Functions and Mechanisms of Redox Regulation of Cysteine-Based Phosphatases

2005 • 295 citations

Diverse Biochemical Properties of Shp2 Mutants

2005 • 278 citations

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations

2005 • 273 citations

Regulation of Insulin Signaling through Reversible Oxidation of the Protein-tyrosine Phosphatases TC45 and PTP1B

2004 • 270 citations

Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation

1993 • 268 citations

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1998 • 268 citations

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

2002 • 263 citations

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

2002 • 260 citations

STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes

2005 • 251 citations

An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity

2000 • 249 citations

The HSPGs Syndecan and Dallylike Bind the Receptor Phosphatase LAR and Exert Distinct Effects on Synaptic Development

2006 • 249 citations

Identification of Substrates of Human Protein-tyrosine Phosphatase PTPN22

2006 • 233 citations

PTPN22 Genetic Variation: Evidence for Multiple Variants Associated with Rheumatoid Arthritis

2005 • 230 citations

Role of Insulin-Induced Reactive Oxygen Species in the Insulin Signaling Pathway

2005 • 228 citations

Promoter methylation of the PTEN gene is a common molecular change in breast cancer

2004 • 218 citations

Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas.

2002 • 205 citations

Heparan Sulfate Proteoglycans Are Ligands for Receptor Protein Tyrosine Phosphatase σ

2002 • 205 citations

The Strength of Receptor Signaling Is Centrally Controlled through a Cooperative Loop between Ca2+ and an Oxidant Signal

2005 • 204 citations

Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-α

1999 • 193 citations

Stops along the RAS pathway in human genetic disease

2006 • 191 citations

Two Vicinal Cysteines Confer a Peculiar Redox Regulation to Low Molecular Weight Protein Tyrosine Phosphatase in Response to Platelet-derived Growth Factor Receptor Stimulation

2001 • 190 citations

Crystal Structure of the Tandem Phosphatase Domains of RPTP LAR

1999 • 174 citations

Myotubularins, a large disease-associated family of cooperating catalytically active and inactive phosphoinositides phosphatases

2003 • 171 citations

The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway

2004 • 171 citations

Dephosphorylation of Cdk2 Thr ¹⁶⁰ by the Cyclin-Dependent Kinase-Interacting Phosphatase KAP in the Absence of Cyclin

1995 • 170 citations

Principles behind the multifarious control of signal transduction

2004 • 167 citations

Subcellular targeting of oxidants during endothelial cell migration

2005 • 166 citations

Redox regulation of protein-tyrosine phosphatases

2004 • 164 citations

Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor

2005 • 157 citations

Homophilic Interactions Mediated by Receptor Tyrosine Phosphatases μ and κ. A CRITICAL ROLE FOR THE NOVEL EXTRACELLULAR MAM DOMAIN

1995 • 156 citations

Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition

1997 • 156 citations

The Heparan Sulfate Proteoglycan Syndecan Is an In Vivo Ligand for the Drosophila LAR Receptor Tyrosine Phosphatase

2005 • 151 citations

Functional analysis of leukemia-associated PTPN11 mutations in primary hematopoietic cells

2005 • 146 citations

Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress

2002 • 146 citations

Functional significance of the LAR receptor protein tyrosine phosphatase family in development and diseases

2004 • 146 citations

Receptor-Like Protein Tyrosine Phosphatase α Homodimerizes on the Cell Surface

2000 • 140 citations

Differential Oxidation of Protein-tyrosine Phosphatases

2004 • 139 citations

Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase

2003 • 138 citations

Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains

1998 • 135 citations

Preferential oxidation of the second phosphatase domain of receptor-like PTP-α revealed by an antibody against oxidized protein tyrosine phosphatases

2004 • 134 citations

The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR

1998 • 134 citations

Sac phosphatase domain proteins

2000 • 132 citations

Oxidative Inhibition of Receptor-type Protein-tyrosine Phosphatase κ by Ultraviolet Irradiation Activates Epidermal Growth Factor Receptor in Human Keratinocytes

2006 • 129 citations

Abrogation of DUSP6 by hypermethylation in human pancreatic cancer

2005 • 128 citations

Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

2005 • 125 citations

Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas

2003 • 122 citations

Reversible Oxidation of ERK-directed Protein Phosphatases Drives Oxidative Toxicity in Neurons

2004 • 121 citations

RETRACTED: Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer

2004 • 120 citations

The Phosphoinositide-3-phosphatase MTMR2 Associates with MTMR13, a Membrane-associated Pseudophosphatase Also Mutated in Type 4B Charcot-Marie-Tooth Disease

2005 • 120 citations

Receptor-stimulated oxidation of SHP-2 promotes T-cell adhesion through SLP-76–ADAP

2005 • 119 citations

Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas.

2003 • 114 citations

Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45

2005 • 107 citations

Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS

2005 • 103 citations

Reactive Oxygen Species Generation Is Involved in Epidermal Growth Factor Receptor Transactivation through the Transient Oxidization of Src Homology 2-Containing Tyrosine Phosphatase in Endothelin-1 Signaling Pathway in Rat Cardiac Fibroblasts

2006 • 103 citations

Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9

2003 • 98 citations

Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O

2006 • 96 citations

Dimerization of Receptor Protein-Tyrosine Phosphatase alpha in living cells

2001 • 92 citations

The structure and regulation of myotubularin phosphatases

2005 • 90 citations

Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase

2006 • 88 citations

The archetype STYX/dead-phosphatase complexes with a spermatid mRNA-binding protein and is essential for normal sperm production

2002 • 86 citations

Characterization of Recombinant CD45 Cytoplasmic Domain Proteins

1998 • 86 citations

Structural Basis for the Recognition of a Bisphosphorylated MAP Kinase Peptide by Human VHR Protein Phosphatase

2002 • 85 citations

Protein tyrosine phosphatase receptor type Z is involved in hippocampus-dependent memory formation through dephosphorylation at Y1105 on p190 RhoGAP

2006 • 81 citations

H2O2-induced Intermolecular Disulfide Bond Formation between Receptor Protein-tyrosine Phosphatases

2004 • 78 citations

Pleiotrophin stimulates tyrosine phosphorylation of β-adducin through inactivation of the transmembrane receptor protein tyrosine phosphatase β/ζ

2005 • 75 citations

Intra- and Intermolecular Interactions between Intracellular Domains of Receptor Protein-tyrosine Phosphatases

2002 • 73 citations

Age-Dependent Enhancement of Hippocampal Long-Term Potentiation and Impairment of Spatial Learning through the Rho-Associated Kinase Pathway in Protein Tyrosine Phosphatase Receptor Type Z-Deficient Mice

2005 • 71 citations

Mammalian capping enzyme binds RNA and uses protein tyrosine phosphatase mechanism

1998 • 66 citations

Protein-tyrosine Phosphatase (PTP) Wedge Domain Peptides

2006 • 66 citations

Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy

2005 • 65 citations

Restoration of Potent Protein−Tyrosine Phosphatase Activity into the Membrane-Distal Domain of Receptor Protein−Tyrosine Phosphatase α

1998 • 62 citations

Overview of protein serine/threonine phosphatases

2003 • 62 citations

Redox-regulated Rotational Coupling of Receptor Protein-tyrosine Phosphatase α Dimers

2003 • 60 citations

Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma.

2006 • 58 citations

The Juxtamembrane Wedge Negatively Regulates CD45 Function in B Cells

2005 • 57 citations

SHP2 forecast for the immune system: fog gradually clearing

2006 • 56 citations

Leukocyte Antigen-Related Protein Tyrosine Phosphatase Receptor: A Small Ectodomain Isoform Functions as a Homophilic Ligand and Promotes Neurite Outgrowth

2003 • 53 citations

Interconversion of the Kinetic Identities of the Tandem Catalytic Domains of Receptor-like Protein-tyrosine Phosphatase PTPα by Two Point Mutations Is Synergistic and Substrate-dependent

1998 • 49 citations

Cloning of hOST-PTP: the only example of a protein-tyrosine-phosphatase the function of which has been lost between rodent and human

2004 • 45 citations

Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth

2005 • 43 citations

JAKing up hematopoietic proliferation

2005 • 42 citations

Technology evaluation: ISIS-113715, Isis.

2004 • 39 citations

A phosphatase for cofilin to be HAD

2005 • 24 citations

Protein tyrosine phosphatase-based therapeutics: lessons from PTP1B

2003 • 17 citations