Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

2004 • 3,873 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 • 1,678 citations

Chronic Myeloid Leukemia

1999 • 1,639 citations

The tor pathway: a target for cancer therapy

2004 • 1,308 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1997 • 1,050 citations

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2003 • 1,019 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Development of “substrate-trapping” mutants to identify physiological substrates of protein tyrosine phosphatases

1997 • 774 citations

PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity

2002 • 765 citations

Versatile retroviral vectors for potential use in gene therapy.

1994 • 690 citations

Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

1996 • 602 citations

Combinatorial control of the specificity of protein tyrosine phosphatases

2001 • 500 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

2004 • 489 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase

1994 • 477 citations

Activation of a Drosophila Janus kinase (JAK) causes hematopoietic neoplasia and developmental defects.

1995 • 460 citations

Shp2 Regulates Src Family Kinase Activity and Ras/Erk Activation by Controlling Csk Recruitment

2004 • 437 citations

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

2003 • 429 citations

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

2004 • 414 citations

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1992 • 400 citations

Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.

1994 • 389 citations

The ‘Gab’ in signal transduction

2003 • 378 citations

Critical role for Gab2 in transformation by BCR/ABL

2002 • 363 citations

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.

1992 • 359 citations

Form and Function in Protein Dephosphorylation

1996 • 334 citations

Development of anticancer drugs targeting the MAP kinase pathway

2000 • 322 citations

Nf1 deficiency causes Ras-Dediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

1996 • 310 citations

An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects.

1995 • 307 citations

Essential role for Gab2 in the allergic response

2001 • 306 citations

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

1998 • 297 citations

Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

2003 • 297 citations

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

2004 • 295 citations

Analysis of Ras-Induced Overproliferation in Drosophila Hemocytes

2003 • 291 citations

Molecular Mechanism for a Role of SHP2 in Epidermal Growth Factor Receptor Signaling

2003 • 280 citations

Clinical pharmacokinetics and therapeutic drug monitoring of sirolimus

2000 • 277 citations

Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2

2002 • 268 citations

Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease

2004 • 264 citations

Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling

2001 • 261 citations

Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes

1998 • 261 citations

Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

2004 • 245 citations

Tyrosyl Phosphorylation of Shp2 Is Required for Normal ERK Activation in Response to Some, but Not All, Growth Factors

2003 • 221 citations

Juvenile Myelomonocytic Leukemia

1997 • 215 citations

Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies.

1995 • 214 citations

Juvenile Myelomonocytic Leukemia

1997 • 203 citations

The gift of Gab

2002 • 201 citations

Role of FLT3 in leukemia

2002 • 201 citations

Occurrence of myeloproliferative disorder in patients with Noonan syndrome

1997 • 176 citations

Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

2004 • 176 citations

A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

1994 • 172 citations

Focus on acute leukemias

2002 • 172 citations

Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor

2004 • 167 citations

Shp2, an SH2-containing Protein-tyrosine Phosphatase, Positively Regulates Receptor Tyrosine Kinase Signaling by Dephosphorylating and Inactivating the Inhibitor Sprouty

2004 • 166 citations

Blood cells of Drosophila: cell lineages and role in host defence

2003 • 162 citations

Nf1 Regulates Hematopoietic Progenitor Cell Growth and Ras Signaling in Response to Multiple Cytokines

1998 • 159 citations

Identification of a Putative Syp Substrate, the PDGFβ Receptor

1995 • 158 citations

Juvenile Myelomonocytic Leukemia and Noonan Syndrome

1999 • 152 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase.

1994 • 144 citations

Hyperactivation of P21ras and the Hematopoietic-Specific Rho Gtpase, Rac2, Cooperate to Alter the Proliferation of Neurofibromin-Deficient Mast Cells in Vivo and in Vitro

2001 • 139 citations

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor

2003 • 137 citations

Requirement of Gab2 for mast cell development and KitL/c-Kit signaling

2002 • 136 citations

The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase

2000 • 135 citations

Tyrosine kinase fusion genes in chronic myeloproliferative diseases

2002 • 131 citations

Imatinib targets other than bcr/abl and their clinical relevance in myeloid disorders

2004 • 130 citations

Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps

2000 • 117 citations

Metabolic effects of sodium metavanadate in humans with insulin- dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies

1995 • 95 citations

Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy

1996 • 86 citations

Characterization of Two SHP-2-associated Binding Proteins and Potential Substrates in Hematopoietic Cells

1997 • 83 citations

MLL-rearranged leukemias: insights from gene expression profiling

2003 • 79 citations

Hyperactivation of protein kinase B and ERK have discrete effects on survival, proliferation, and cytokine expression in Nf1-deficient myeloid cells

2002 • 66 citations

Fruit fly “leukemia”

1998 • 63 citations

Distinct sequences on 11q13.5 and 11q23–24 are frequently coamplified with MLL in complexly organized 11q amplicons in AML/MDS patients

2004 • 34 citations

Drosophila awdK–pn, a homologue of the metastasis suppressor gene nm23, suppresses the Tum–I haematopoietic oncogene

1993 • 32 citations