Cellular signaling by fibroblast growth factor receptors

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Signaling—2000 and Beyond

2000 • 2,544 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

Fibroblast growth factors.

2001 • 1,946 citations

Receptor Specificity of the Fibroblast Growth Factor Family

1996 • 1,871 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,343 citations

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

2004 • 1,286 citations

Fgf10 is essential for limb and lung formation

1999 • 1,204 citations

Protein Kinase Inhibitors: Insights into Drug Design from Structure

2004 • 1,180 citations

Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization

2000 • 1,146 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

Fibroblast Growth Factor Receptor 3 Is a Negative Regulator of Bone Growth

1996 • 1,062 citations

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1998 • 1,048 citations

Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless

1998 • 869 citations

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3

1996 • 867 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules

1991 • 848 citations

An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis

2000 • 847 citations

Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome

2003 • 808 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation.

1994 • 784 citations

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene.

1992 • 760 citations

Murine FGFR-1 is required for early postimplantation growth and axial organization.

1994 • 748 citations

Requirement of FGF-4 for Postimplantation Mouse Development

1995 • 743 citations

Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas

1999 • 697 citations

The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules

1991 • 673 citations

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

1994 • 665 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

1997 • 657 citations

Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells.

1992 • 634 citations

Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction

1992 • 625 citations

Structural Basis for FGF Receptor Dimerization and Activation

1999 • 597 citations

FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations

1994 • 575 citations

Male-to-Female Sex Reversal in Mice Lacking Fibroblast Growth Factor 9

2001 • 562 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction

1998 • 555 citations

Developmental Localization of the Splicing Alternatives of Fibroblast Growth Factor Receptor-2 (FGFR2)

1993 • 551 citations

Keratinocyte growth factor is required for hair development but not for wound healing.

1996 • 541 citations

Craniosynostosis: genes and mechanisms

1997 • 528 citations

FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung

1998 • 483 citations

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain

1998 • 477 citations

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

2002 • 468 citations

Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18

2002 • 463 citations

Mice homozygous for a targeted disruption of the proto-oncogeneint-2have developmental defects in the tail and inner ear

1993 • 446 citations

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1.

1991 • 443 citations

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity

1992 • 441 citations

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

1992 • 438 citations

Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice

1998 • 437 citations

Crystal Structures of Two FGF-FGFR Complexes Reveal the Determinants of Ligand-Receptor Specificity

2000 • 401 citations

Structure of the FGF Receptor Tyrosine Kinase Domain Reveals a Novel Autoinhibitory Mechanism

1996 • 376 citations

Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development

1999 • 367 citations

FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors

2000 • 355 citations

FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome

1998 • 332 citations

Lung hypoplasia and neonatal death inFgf9-null mice identify this gene as an essential regulator of lung mesenchyme

2001 • 331 citations

FGFR activation in skeletal disorders: Too much of a good thing

1997 • 319 citations

A role for FGF-6 in skeletal muscle regeneration

1997 • 316 citations

Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice

2000 • 316 citations

The fibroblast growth factor receptor 3 (FGFR3) mutation is a strong indicator of superficial bladder cancer with low recurrence rate.

2001 • 302 citations

Clinical spectrum of fibroblast growth factor receptor mutations

1999 • 293 citations

Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways

2001 • 287 citations

FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain

2004 • 279 citations

Mutations in fibroblast growth factor receptor 2 and fibroblast growth factor receptor 3 genes associated with human gastric and colorectal cancers.

2001 • 278 citations

Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures

2000 • 268 citations

Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome

2000 • 261 citations

TheIIIcalternative ofFgfr2is a positive regulator of bone formation

2002 • 252 citations

Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas.

1994 • 243 citations

Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis

1999 • 243 citations

A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures

2000 • 227 citations

Opposite phenotypes of hypomorphic and Y766 phosphorylation site mutations reveal a function for Fgfr1 in anteroposterior patterning of mouse embryos

1998 • 225 citations

A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3

1999 • 223 citations

FGF signaling through FGFR1 is required for olfactory bulb morphogenesis

2003 • 212 citations

Fibroblast Growth Factor (FGF)-23 Inhibits Renal Phosphate Reabsorption by Activation of the Mitogen-activated Protein Kinase Pathway

2002 • 211 citations

A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos

2000 • 208 citations

A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis

2004 • 207 citations

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome

2001 • 198 citations

The t(6;8)(q27;p11) Translocation in a Stem Cell Myeloproliferative Disorder Fuses a Novel Gene, FOP, to Fibroblast Growth Factor Receptor 1

1999 • 198 citations

The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

2001 • 191 citations

Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer

1997 • 191 citations

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity

2004 • 188 citations

Ataxia and Paroxysmal Dyskinesia in Mice Lacking Axonally Transported FGF14

2002 • 177 citations

A Ser250Trp substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis

2003 • 174 citations

FRS2α attenuates FGF receptor signaling by Grb2- mediated recruitment of the ubiquitin ligase Cbl

2002 • 174 citations

A confined variable region confers ligand specificity on fibroblast growth factor receptors: implications for the origin of the immunoglobulin fold.

1992 • 165 citations

Consistent Fusion of ZNF198 to the Fibroblast Growth Factor Receptor-1 in the t(8;13)(p11;q12) Myeloproliferative Syndrome

1998 • 164 citations

Alternately Spliced NH2-terminal Immunoglobulin-like Loop I in the Ectodomain of the Fibroblast Growth Factor (FGF) Receptor 1 Lowers Affinity for both Heparin and FGF-1

1995 • 157 citations

The Docking Protein FRS2α Controls a MAP Kinase-Mediated Negative Feedback Mechanism for Signaling by FGF Receptors

2002 • 155 citations

Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13)(p12;q12)

1998 • 154 citations

A Ser365->Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh/PTHrP signals and causes severe achondroplasia

2001 • 154 citations

Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations

2004 • 152 citations

FGFR1 is fused to the centrosome-associated proteinCEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)

2000 • 146 citations

Aberrant expression of type I fibroblast growth factor receptor in human pancreatic adenocarcinomas.

1993 • 145 citations

A new myeloproliferative disorder associated with chromosomal translocations involving 8p11: a review.

1995 • 143 citations

Mouse FGF15 is the ortholog of human and chick FGF19, but is not uniquely required for otic induction

2004 • 125 citations

Autoinhibition Control

2003 • 118 citations

Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice

2001 • 117 citations

The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP

1998 • 112 citations

Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma

2004 • 109 citations

Structural Basis of SNT PTB Domain Interactions with Distinct Neurotrophic Receptors

2000 • 97 citations

Fusion of the BCR and the fibroblast growth factor receptor‐1 (FGFR1) genes as a result of t(8;22)(p11;q11) in a myeloproliferative disorder: The first fusion gene involving BCR but not ABL

2001 • 96 citations

Alternative splicing of fibroblast growth factor receptors in human prostate cancer

2001 • 93 citations

The incidence of thanatophoric dysplasia mutations inFGFR3 gene is higher in low-grade or superficial bladder carcinomas

2001 • 92 citations

Kallmann syndrome: fibroblast growth factor signaling insufficiency?

2004 • 92 citations

Inborn errors of development : the molecular basis of clinical disorders of morphogenesis

2004 • 92 citations

Fusion of ETV6 to fibroblast growth factor receptor 3 in peripheral T-cell lymphoma with a t(4;12)(p16;p13) chromosomal translocation.

2001 • 91 citations

Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours

2001 • 89 citations

Fgf18 is required for embryonic lung alveolar development

2004 • 88 citations

Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem-cell myeloproliferative disorder with t(8;19)(p12;q13.3)

2002 • 84 citations

The Expression and Localization of Fibroblast Growth Factor-1 (FGF-1) and FGF Receptor-1 (FGFR-1) in Human Breast Cancer

1998 • 78 citations

FGFR4 overexpression in pancreatic cancer is mediated by an intronic enhancer activated by HNF1α

2002 • 58 citations

Novel transcripts of fibroblast growth factor receptor 3 reveal aberrant splicing and activation of cryptic splice sequences in colorectal cancer.

2000 • 55 citations

Lin, X., Buff, E. M., Perrimon, N. & Michelson, A. M. Heparan sulfate proteoglycans are essential for FGF receptor signaling during Drosophila embryonic development. Development 126, 3715-3723

1999 • 45 citations

Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix

2000 • 38 citations

Overexpression of fibroblast growth factor receptor 3 in a human thyroid carcinoma cell line results in overgrowth of the confluent cultures

1999 • 31 citations