The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Role of CD47 as a Marker of Self on Red Blood Cells

2000 • 1,702 citations

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 • 1,678 citations

Immune Inhibitory Receptors

2000 • 1,283 citations

Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

2002 • 1,020 citations

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2003 • 1,019 citations

SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein

2002 • 1,004 citations

Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals

1995 • 956 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

The ras gene family and human carcinogenesis

1988 • 786 citations

PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity

2002 • 765 citations

sprouty Encodes a Novel Antagonist of FGF Signaling that Patterns Apical Branching of the Drosophila Airways

1998 • 745 citations

Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

2001 • 694 citations

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

1999 • 542 citations

Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

2002 • 539 citations

Transmembrane phosphoprotein Cbp regulates the activities of Src-family tyrosine kinases

2000 • 527 citations

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

2000 • 465 citations

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains (Pag), a Novel Ubiquitously Expressed Transmembrane Adaptor Protein, Binds the Protein Tyrosine Kinase Csk and Is Involved in Regulation of T Cell Activation

2000 • 457 citations

Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor–Mediated Phagocytosis

2001 • 409 citations

SOCS3 Exerts Its Inhibitory Function on Interleukin-6 Signal Transduction through the SHP2 Recruitment Site of gp130

2000 • 393 citations

Protein-tyrosine Phosphatase Shp-2 Regulates Cell Spreading, Migration, and Focal Adhesion

1998 • 390 citations

Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.

1994 • 369 citations

Grb2 Is a Key Mediator of Helicobacter pylori CagA Protein Activities

2002 • 364 citations

Critical role for Gab2 in transformation by BCR/ABL

2002 • 363 citations

Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule

1999 • 347 citations

CIS3/SOCS-3 Suppresses Erythropoietin (EPO) Signaling by Binding the EPO Receptor and JAK2

2000 • 339 citations

Coupling of Gab1 to C-Met, Grb2, and Shp2 Mediates Biological Responses

2000 • 333 citations

Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling

2000 • 320 citations

Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

2001 • 314 citations

Cloning of p97/Gab2, the Major SHP2-Binding Protein in Hematopoietic Cells, Reveals a Novel Pathway for Cytokine-Induced Gene Activation

1998 • 313 citations

Revealing mechanisms for SH2 domain mediated regulation of the protein tyrosine phosphatase SHP-2

1998 • 297 citations

Fyn-Binding Protein (Fyb)/Slp-76–Associated Protein (Slap), Ena/Vasodilator-Stimulated Phosphoprotein (Vasp) Proteins and the Arp2/3 Complex Link T Cell Receptor (Tcr) Signaling to the Actin Cytoskeleton

2000 • 294 citations

Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many

1999 • 291 citations

Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways

2001 • 287 citations

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

2001 • 282 citations

The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

2000 • 278 citations

Receptor protein tyrosine phosphatase α activates Src-family kinases and controls integrin-mediated responses in fibroblasts

1999 • 273 citations

Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2

2002 • 268 citations

Protein-tyrosine-phosphatase SHPTP2 is a required positive effector for insulin downstream signaling.

1995 • 263 citations

Site-Specific Incorporation of a Phosphotyrosine Mimetic Reveals a Role for Tyrosine Phosphorylation of SHP-2 in Cell Signaling

2001 • 261 citations

Role of Gab1 in Heart, Placenta, and Skin Development and Growth Factor- and Cytokine-Induced Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Activation

2000 • 258 citations

Essential Role of Gab1 for Signaling by the C-Met Receptor in Vivo

2000 • 255 citations

Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility

1999 • 254 citations

The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation

2003 • 253 citations

Mammalian Sprouty Proteins Inhibit Cell Growth and Differentiation by Preventing Ras Activation

2001 • 246 citations

Molecular Mechanism for the Shp-2 Tyrosine Phosphatase Function in Promoting Growth Factor Stimulation of Erk Activity

2000 • 230 citations

Regulation of Early Events in Integrin Signaling by Protein Tyrosine Phosphatase SHP-2

1999 • 219 citations

Juvenile Myelomonocytic Leukemia

1997 • 215 citations

Targeted disruption of the tyrosine phosphatase PTPα leads to constitutive downregulation of the kinases Src and Fyn

1999 • 207 citations

Interaction of Growth Hormone-activated STATs with SH2-containing Phosphotyrosine Phosphatase SHP-1 and Nuclear JAK2 Tyrosine Kinase

1997 • 205 citations

Juvenile Myelomonocytic Leukemia

1997 • 203 citations

Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils

2002 • 176 citations

CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion

1997 • 170 citations

The tyrosine phosphatase SHP-2 is required for mediating phosphatidylinositol 3-kinase/Akt activation by growth factors

2001 • 169 citations

Regulation of the Mitogen-activated Protein Kinase Signaling Pathway by SHP2

2002 • 160 citations

Phosphotyrosines 627 and 659 of Gab1 Constitute a Bisphosphoryl Tyrosine-based Activation Motif (BTAM) Conferring Binding and Activation of SHP2

2001 • 160 citations

Identification of a Putative Syp Substrate, the PDGFβ Receptor

1995 • 158 citations

The Shp-2 Tyrosine Phosphatase Has Opposite Effects in Mediating the Activation of Extracellular Signal-regulated and c-Jun NH2-terminal Mitogen-activated Protein Kinases

1998 • 155 citations

Juvenile Myelomonocytic Leukemia and Noonan Syndrome

1999 • 152 citations

Genetic analysis of protein tyrosine phosphatases

1998 • 145 citations

Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2

1998 • 145 citations

Differential association of phosphatases with hematopoietic co‐receptors bearing immunoreceptor tyrosine‐based inhibition motifs

1997 • 143 citations

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility

2000 • 143 citations

The protein tyrosine phosphatase Shp-2 regulates RhoA activity

2000 • 138 citations

Modulation of the Nuclear Factor κb Pathway by Shp-2 Tyrosine Phosphatase in Mediating the Induction of Interleukin (Il)-6 by IL-1 or Tumor Necrosis Factor

2001 • 130 citations

Biased Suppression of Hematopoiesis and Multiple Developmental Defects in Chimeric Mice Containing Shp-2 Mutant Cells

1998 • 130 citations

The SH2 tyrosine phosphatase Shp2 is required for mammalian limb development

2000 • 127 citations

The distal region and receptor tyrosines of the Epo receptor are non-essential for in vivo erythropoiesis

2001 • 122 citations

Crystal Structure of the Catalytic Domain of Protein-tyrosine Phosphatase SHP-1

1998 • 120 citations

Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps

2000 • 117 citations

Structural Determinants of SHP-2 Function and Specificity in Xenopus Mesoderm Induction

1998 • 115 citations

PTPN11(Protein-Tyrosine Phosphatase, Nonreceptor-Type 11) Mutations in Seven Japanese Patients with Noonan Syndrome

2002 • 112 citations

The torso receptor tyrosine kinase can activate raf in a ras-independent pathway

1995 • 111 citations

SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages

1999 • 110 citations

The SH2-containing tyrosine phosphatase corkscrew is required during signaling by sevenless, Ras1 and Raf

1996 • 102 citations

Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr

2000 • 98 citations

The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer

2002 • 95 citations

Roles for the protein tyrosine phosphatase SHP-2 in cytoskeletal organization, cell adhesion and cell migration revealed by overexpression of a dominant negative mutant

2000 • 94 citations

Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin

2001 • 93 citations

The protein tyrosine phosphatase SHP-1 regulates integrin-mediated adhesion of macrophages

1998 • 92 citations

Opposing Actions of CSW and RasGAP Modulate the Strength of Torso RTK Signaling in the Drosophila Terminal Pathway

1998 • 92 citations

Morphogenetic movements at gastrulation require the SH2 tyrosine phosphatase Shp2

1999 • 90 citations

Genetic heterogeneity in Noonan syndrome: Evidence for an autosomal recessive form

2000 • 80 citations

Deficiency of Src Homology 2-Containing Phosphatase 1 Results in Abnormalities in Murine Neutrophil Function: Studies inMotheatenMice

2000 • 79 citations

The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development

1998 • 76 citations

A Functional Nuclear Localization Sequence in the C-terminal Domain of SHP-1

2001 • 66 citations

The Caenorhabditis elegans EGL-15 Signaling Pathway Implicates a DOS-Like Multisubstrate Adaptor Protein in Fibroblast Growth Factor Signal Transduction

2001 • 59 citations

Determination of the Binding Specificity of the SH2 Domains of Protein Tyrosine Phosphatase SHP-1 through the Screening of a Combinatorial Phosphotyrosyl Peptide Library

2000 • 59 citations

Specificity of the SH2 Domains of SHP-1 in the Interaction with the Immunoreceptor Tyrosine-Based Inhibitory Motif-Bearing Receptor gp49B

1999 • 59 citations

Recruitment of the protein tyrosine phosphatase CSW by DOS is an essential step during signaling by the Sevenless receptor tyrosine kinase

1999 • 49 citations

Analysis of Corkscrew Signaling in the Drosophila Epidermal Growth Factor Receptor Pathway During Myogenesis

2001 • 33 citations

PTPN11 (Protein-Tyrosine Phosphatase, Nonreceptor-Type 11) Mutations in Seven Japanese Patients with Noonan Syndrome

2002 • 30 citations

SH2 Domain-Containing Protein-Tyrosine Phosphatases

2010 • 30 citations

In vivo functional analysis of the Daughter of Sevenless protein in receptor tyrosine kinase signaling

2000 • 28 citations

Mutational Analysis of the SRC Homology 2 Domain Protein-tyrosine Phosphatase Corkscrew

1998 • 25 citations

A Bipartite NLS at the SHP-1 C-Terminus Mediates Cytokine-Induced SHP-1 Nuclear Localization in Cell Growth Control

2002 • 23 citations

An immunoreceptor tyrosine-based inhibitory motif, with serine at site Y-2, binds SH2-domain-containing phosphatases

2000 • 19 citations