Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance

The Hallmarks of Cancer

2000 • 27,569 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Promotion of microtubule assembly in vitro by taxol

1979 • 3,521 citations

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1

2004 • 3,278 citations

Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism

2003 • 2,691 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Taxol stabilizes microtubules in mouse fibroblast cells.

1980 • 1,942 citations

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 • 1,678 citations

Pten is essential for embryonic development and tumour suppression

1998 • 1,507 citations

The tor pathway: a target for cancer therapy

2004 • 1,308 citations

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 • 1,226 citations

Unlocking the potential of the human genome with RNA interference

2004 • 1,066 citations

Protein Kinase SGK Mediates Survival Signals by Phosphorylating the Forkhead Transcription Factor FKHRL1 (FOXO3a)

2001 • 850 citations

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1998 • 823 citations

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.

1992 • 732 citations

Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers

2004 • 517 citations

Analysis of Events Associated With Cell Cycle Arrest at G2 Phase and Cell Death Induced by Cisplatin

1990 • 447 citations

Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

2003 • 433 citations

Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy.

2002 • 431 citations

Reduced MAP Kinase Phosphatase-1 Degradation After p42/p44 ^MAPK -Dependent Phosphorylation

1999 • 414 citations

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

1999 • 349 citations

A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration

2003 • 324 citations

Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway

2002 • 313 citations

ErbB2 Potentiates Breast Tumor Proliferation through Modulation of p27^Kip1-Cdk2 Complex Formation: Receptor Overexpression Does Not Determine Growth Dependency

2000 • 304 citations

Mechanism of Action of Antitumor Drug Etoposide: A Review

1988 • 291 citations

Forkhead transcription factors contribute to execution of the mitotic programme in mammals

2001 • 282 citations

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations

2005 • 273 citations

Small-molecule cyclin-dependent kinase modulators

2003 • 235 citations

Cooperation of the ErbB2 receptor and transforming growth factor β in induction of migration and invasion in mammary epithelial cells

2004 • 224 citations

MEK Inhibition Enhances Paclitaxel-induced Tumor Apoptosis

2000 • 222 citations

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

2003 • 192 citations

Inhibitors of mammalian target of rapamycin as novel antitumor agents: from bench to clinic.

2002 • 183 citations

Proteomic profiling drug-induced apoptosis in non-small cell lung carcinoma: identification of RS/DJ-1 and RhoGDIalpha.

2003 • 154 citations

Gathering STYX: phosphatase-like form predicts functions for unique protein-interaction domains

1998 • 135 citations

A Single Mutation Converts a Novel Phosphotyrosine Binding Domain into a Dual-specificity Phosphatase

1995 • 121 citations

Calcium/Calmodulin-dependent Protein Kinase II Regulation of c-FLIP Expression and Phosphorylation in Modulation of Fas-mediated Signaling in Malignant Glioma Cells

2003 • 88 citations

Inactivation of the antiapoptotic phosphatidylinositol 3-kinase-Akt pathway by the combined treatment of taxol and mitogen-activated protein kinase kinase inhibition.

2002 • 78 citations

Human JIK, a Novel Member of the STE20 Kinase Family That Inhibits JNK and Is Negatively Regulated by Epidermal Growth Factor

1999 • 77 citations

Genetic analysis identifies putative tumor suppressor sites at 2q35–q36.1 and 2q36.3–q37.1 involved in cervical cancer progression

2003 • 69 citations

Expression of the c-erbB2 gene in the BT474 human mammary tumor cell line: measurement of c-erbB2 mRNA half-life.

1993 • 58 citations

Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy?

2001 • 45 citations