The Strength of Receptor Signaling Is Centrally Controlled through a Cooperative Loop between Ca2+ and an Oxidant Signal

Two‐dimensional electrophoresis. The current state of two‐dimensional electrophoresis with immobilized pH gradients

1988 • 2,431 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

Emergent Properties of Networks of Biological Signaling Pathways

1999 • 1,696 citations

The current state of two-dimensional electrophoresis with immobilized pH gradients

2000 • 1,498 citations

Oxidant signals and oxidative stress

2003 • 1,378 citations

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

2002 • 1,107 citations

Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

2002 • 1,020 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Hydrogen peroxide as second messenger in lymphocyte activation

2002 • 760 citations

Complexity in Biological Signaling Systems

1999 • 614 citations

A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes

2001 • 598 citations

Mathematical Models of Protein Kinase Signal Transduction

2002 • 525 citations

Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade

2001 • 511 citations

Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation

2002 • 447 citations

T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

2004 • 441 citations

Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling

2003 • 382 citations

Specificity of a third kind: reactive oxygen and nitrogen intermediates in cell signaling

2003 • 381 citations

Mechanism of Ca2+ Activation of the NADPH Oxidase 5 (NOX5)

2004 • 371 citations

Novel homologs of gp91phox

2000 • 356 citations

Monomeric and Oligomeric Complexes of the B Cell Antigen Receptor

2000 • 279 citations

Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis

1998 • 261 citations

Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling.

1995 • 260 citations

BLNK

2000 • 221 citations

BTK Regulates PtdIns-4,5-P2 Synthesis

2003 • 214 citations

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

1992 • 181 citations

The CD45 tyrosine phosphatase: a positive and negative regulator of immune cell function

2000 • 155 citations

Signaling Networks—Do All Roads Lead to the Same Genes?

1999 • 142 citations

Calcium signalling in lymphocytes

2003 • 119 citations

Recruitment and Activation of SHP-1 Protein-tyrosine Phosphatase by Human Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1)

1998 • 116 citations

Signaling Complexes: Junctions on the Intracellular Information Super Highway

2002 • 116 citations

Regulation of B cell fates by BCR signaling components

2002 • 108 citations

Amplification of receptor signalling by Ca2+ entry-mediated translocation and activation of PLC 2 in B lymphocytes

2003 • 108 citations

Feedback regulation of lymphocyte signalling

2004 • 89 citations

Basal B‐cell receptor signaling in B lymphocytes: mechanisms of regulation and role in positive selection, differentiation, and peripheral survival

2004 • 78 citations

Regulation of oxidative stress-induced calcium release by phosphatidylinositol 3-kinase and Bruton's tyrosine kinase in B cells

2000 • 52 citations

Negative Regulation of the SHPTP1 Protein Tyrosine Phosphatase by Protein Kinase C δ in Response to DNA Damage

2001 • 50 citations

Characterization of EhCaBP, a calcium-binding protein of Entamoeba histolytica and its binding proteins

1997 • 38 citations

The Putative Morphogen, DIF-1, of Dictyostelium discoideum Activates Akt/PKB in Human Leukemia K562 Cells

1999 • 34 citations

Mechanism of hydrogen peroxide production in porcine thyroid cells: evidence for intermediary formation of superoxide anion by NADPH-dependent hydrogen peroxide-generating machinery

1991 • 26 citations