Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

Reactive oxygen species in cell signaling

2000 • 2,844 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

Structure, mechanism and regulation of peroxiredoxins

2003 • 2,454 citations

Cellular response to oxidative stress: Signaling for suicide and survival*

2002 • 2,258 citations

Peroxiredoxin Evolution and the Regulation of Hydrogen Peroxide Signaling

2003 • 1,317 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation

1995 • 1,185 citations

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1998 • 1,180 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo

2002 • 1,020 citations

Crystal Structure of the PTEN Tumor Suppressor

1999 • 1,011 citations

Reversible Inactivation of the Tumor Suppressor PTEN by H2O2

2002 • 1,010 citations

Reversible Inactivation of Protein-tyrosine Phosphatase 1B in A431 Cells Stimulated with Epidermal Growth Factor

1998 • 968 citations

Thioredoxin-dependent peroxide reductase from yeast.

1994 • 940 citations

Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

1998 • 933 citations

Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate

2003 • 930 citations

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

2003 • 926 citations

Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.

1994 • 743 citations

Mammalian Peroxiredoxin Isoforms Can Reduce Hydrogen Peroxide Generated in Response to Growth Factors and Tumor Necrosis Factor-α

1998 • 672 citations

Hydrogen Peroxide: A Key Messenger That Modulates Protein Phosphorylation Through Cysteine Oxidation

2000 • 638 citations

Oxidation state of the active-site cysteine in protein tyrosine phosphatase 1B

2003 • 627 citations

Peroxiredoxin, a Novel Family of Peroxidases

2001 • 616 citations

Reversible oxidation and inactivation of the tumor suppressor PTEN in cells stimulated with peptide growth factors

2004 • 605 citations

Redox regulation of PI 3-kinase signalling via inactivation of PTEN

2003 • 592 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Peroxiredoxins

2002 • 555 citations

Reversing the Inactivation of Peroxiredoxins Caused by Cysteine Sulfinic Acid Formation

2003 • 544 citations

Insulin-stimulated Hydrogen Peroxide Reversibly Inhibits Protein-tyrosine Phosphatase 1B in Vivo and Enhances the Early Insulin Action Cascade

2001 • 511 citations

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H₂O₂ and Plays an Integral Role in Insulin Signal Transduction

2004 • 506 citations

Identification of a New Type of Mammalian Peroxiredoxin That Forms an Intramolecular Disulfide as a Reaction Intermediate

2000 • 459 citations

PTEN and Myotubularin: Novel Phosphoinositide Phosphatases

2001 • 454 citations

Inactivation of Human Peroxiredoxin I during Catalysis as the Result of the Oxidation of the Catalytic Site Cysteine to Cysteine-sulfinic Acid

2002 • 449 citations

Characterization of a Mammalian Peroxiredoxin That Contains One Conserved Cysteine

1998 • 439 citations

Proteomics Analysis of Cellular Response to Oxidative Stress

2002 • 388 citations

Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

2004 • 375 citations

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

1997 • 372 citations

Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B

1999 • 353 citations

Platelet-derived Growth Factor-induced H2O2 Production Requires the Activation of Phosphatidylinositol 3-Kinase

2000 • 309 citations

Dimerization of thiol-specific antioxidant and the essential role of cysteine 47.

1994 • 309 citations

Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7Å resolution

2000 • 296 citations

Reversible Oxidation of the Active Site Cysteine of Peroxiredoxins to Cysteine Sulfinic Acid

2003 • 232 citations

Sequential Activation of Phosphatidylinositol 3-Kinase, βPix, Rac1, and Nox1 in Growth Factor-Induced Production of H₂O₂

2004 • 223 citations

Roles of Aspartic Acid-181 and Serine-222 in Intermediate Formation and Hydrolysis of the Mammalian Protein-Tyrosine-Phosphatase PTP1

1997 • 176 citations

The Major Target of the Endogenously Generated Reactive Oxygen Species in Response to Insulin Stimulation Is Phosphatase and Tensin Homolog and Not Phosphoinositide-3 Kinase (PI-3 Kinase) in the PI-3 Kinase/Akt Pathway

2004 • 171 citations

Distribution of glutathione peroxidases glutathione reductase in rat brain mitochondria

1991 • 73 citations