A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage

Initial sequencing and analysis of the human genome

2001 • 23,520 citations

The Sequence of the Human Genome

2001 • 13,500 citations

The Protein Kinase Complement of the Human Genome

2002 • 7,708 citations

Initial sequencing and comparative analysis of the mouse genome

2002 • 6,971 citations

Genome Sequence of the Nematode C. elegans : A Platform for Investigating Biology

1998 • 3,683 citations

Oncogenic kinase signalling

2001 • 3,632 citations

Genome sequence of the nematode C-elegans: A platform for investigating biology

1998 • 3,265 citations

Signal transduction by lymphocyte antigen receptors

1994 • 2,145 citations

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 • 1,678 citations

Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

2000 • 1,218 citations

The protein tyrosine kinase family of the human genome

2000 • 1,107 citations

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2003 • 1,019 citations

Role of Src expression and activation in human cancer

2000 • 832 citations

Human LINE retrotransposons generate processed pseudogenes

2000 • 807 citations

PTP1B Regulates Leptin Signal Transduction In Vivo

2002 • 785 citations

PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity

2002 • 765 citations

The Human Transcriptome Map: Clustering of Highly Expressed Genes in Chromosomal Domains

2001 • 736 citations

CD45: An Emerging Role as a Protein Tyrosine Phosphatase Required for Lymphocyte Activation and Development

1994 • 733 citations

Structural and Evolutionary Relationships among Protein Tyrosine Phosphatase Domains

2001 • 694 citations

A genome–wide search for human non–insulin–dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2

1996 • 601 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B

2002 • 539 citations

Guidelines for Human Gene Nomenclature

2002 • 511 citations

Combinatorial control of the specificity of protein tyrosine phosphatases

2001 • 500 citations

Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2

1997 • 474 citations

Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase

1992 • 455 citations

mRNA localization: message on the move

2001 • 398 citations

Translational regulation in development

1995 • 394 citations

Vertebrate pseudogenes

2000 • 388 citations

Role of the hepatocyte growth factor receptor, c-Met, in oncogenesis and potential for therapeutic inhibition

2002 • 387 citations

CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation.

1996 • 382 citations

A computational analysis of sequence features involved in recognition of short introns

2001 • 368 citations

Protein tyrosine phosphatases: prospects for therapeutics

2001 • 344 citations

On the antiquity of introns

1986 • 324 citations

Large clusters of co-expressed genes in the Drosophila genome

2002 • 322 citations

Integration of cytogenetic landmarks into the draft sequence of the human genome

2001 • 320 citations

Mutations in the tyrosine phosphatase CD45 gene in a child with severe combined immunodeficiency disease

2000 • 306 citations

CD45: new jobs for an old acquaintance

2001 • 286 citations

Mapping a gene for Noonan syndrome to the long arm of chromosome 12

1994 • 285 citations

Dimerization-Induced Inhibition of Receptor Protein Tyrosine Phosphatase Function Through an Inhibitory Wedge

1998 • 268 citations

Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms

2002 • 263 citations

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

2002 • 260 citations

An Inactivating Point Mutation in the Inhibitory Wedge of CD45 Causes Lymphoproliferation and Autoimmunity

2000 • 249 citations

Comparative genomics: genome-wide analysis in metazoan eukaryotes

2003 • 236 citations

Identification of an obesity quantitative trait locus on mouse chromosome 2 and evidence of linkage to body fat and insulin on the human homologous region 20q.

1997 • 232 citations

Genome Scan for Human Obesity and Linkage to Markers in 20q13

1999 • 232 citations

Epidermal Growth Factor Receptor and the Adaptor Protein p52^Shc Are Specific Substrates of T-Cell Protein Tyrosine Phosphatase

1998 • 226 citations

Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs

1999 • 220 citations

Linkage of Genetic Markers on Human Chromosomes 20 and 12 to NIDDM in Caucasian Sib Pairs With a History of Diabetic Nephropathy

1997 • 214 citations

Studying Genomes Through the Aeons: Protein Families, Pseudogenes and Proteome Evolution

2002 • 209 citations

Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21.

1991 • 207 citations

Molecular Fossils in the Human Genome: Identification and Analysis of the Pseudogenes in Chromosomes 21 and 22

2002 • 195 citations

A point mutation in PTPRC is associated with the development of multiple sclerosis

2000 • 194 citations

A Variation in 3′ UTR of hPTP1B Increases Specific Gene Expression and Associates with Insulin Resistance

2002 • 186 citations

Protein tyrosine phosphatases as adhesion receptors

1995 • 182 citations

A Deletion in the Gene Encoding the CD45 Antigen in a Patient with SCID

2001 • 175 citations

Hepatocyte Growth Factor Receptor Tyrosine Kinase Met Is a Substrate of the Receptor Protein-tyrosine Phosphatase DEP-1

2003 • 173 citations

Nature and Structure of Human Genes that Generate Retropseudogenes

2000 • 159 citations

A Low Number Wins the GeneSweep Pool

2003 • 150 citations

Selective Down-regulation of the Insulin Receptor Signal by Protein-tyrosine Phosphatases α and ∊

1995 • 147 citations

Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene.

1992 • 143 citations

mRNA turnover

2001 • 142 citations

A CD45 Polymorphism Associated with Multiple Sclerosis Disrupts an Exonic Splicing Silencer

2001 • 117 citations

Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas.

2003 • 114 citations

Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3.

1999 • 111 citations

Increased expression of specific protein tyrosine phosphatases in human breast epithelial cells neoplastically transformed by the neu oncogene.

1993 • 105 citations

Diversity in translational regulation

2001 • 98 citations

Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice.

1996 • 91 citations

Protein tyrosine phosphatases: counting the trees in the forest

1998 • 87 citations

Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation

2003 • 84 citations

Identification of a cytoplasmic, phorbol ester-inducible isoform of protein tyrosine phosphatase epsilon.

1995 • 84 citations

A P387L Variant in Protein Tyrosine Phosphatase-1B (PTP-1B) Is Associated With Type 2 Diabetes and Impaired Serine Phosphorylation of PTP-1B In Vitro

2002 • 82 citations

Fine mapping of Noonan/cardio-facio cutaneous syndrome in a large family

1998 • 78 citations

Expression of protein tyrosine phosphatase alpha (RPTPα) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo

2000 • 75 citations

Elevated Expression and Activity of Protein-Tyrosine Phosphatase 1B in Skeletal Muscle of Insulin-Resistant Type II Diabetic Goto-Kakizaki Rats

2000 • 75 citations

The Noncatalytic C-terminal Segment of the T Cell Protein Tyrosine Phosphatase Regulates Activity via an Intramolecular Mechanism

1997 • 72 citations

A Single Nucleotide Polymorphism in Protein Tyrosine Phosphatase PTP-1B Is Associated with Protection from Diabetes or Impaired Glucose Tolerance in Oji-Cree

2002 • 71 citations

PTPRC (CD45) is not associated with the development of multiple sclerosis in U.S. patients

2001 • 64 citations

Distinct promoters control transmembrane and cytosolic protein tyrosine phosphatase ε expression during macrophage differentiation

1999 • 54 citations

Increased mRNA expression of the receptor-like protein tyrosine phosphatase α in late stage colon carcinomas

1995 • 52 citations

Suppression of v-fms-induced transformation by overexpression of a truncated T-cell protein tyrosine phosphatase.

1993 • 48 citations

Intron distribution difference for 276 ancient and 131 modern genes suggests the existence of ancient introns

2001 • 48 citations

Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes

2000 • 43 citations

Centripetal modules and ancient introns

1999 • 42 citations

HERV-K-T47D-Related Long Terminal Repeats Mediate Polyadenylation of Cellular Transcripts

2000 • 41 citations

Receptor-like Protein-tyrosine Phosphatase α Specifically Inhibits Insulin-increased Prolactin Gene Expression

1998 • 40 citations

Proliferating and Migrating Mesangial Cells Responding to Injury Express a Novel Receptor Protein-tyrosine Phosphatase in Experimental Mesangial Proliferative Glomerulonephritis

1998 • 39 citations

Challenges in identifying genetic variation affecting susceptibility to type 2 diabetes: examples from studies of the calpain-10 gene

2001 • 38 citations

Protein tyrosine phosphatase receptor-type C exon 4 gene mutation distribution in an Italian multiple sclerosis population

2002 • 37 citations

Differential screening of a human chromosome 3 library identifies hepatocyte growth factor-like/macrophage-stimulating protein and its receptor in injured lung. Possible implications for neuroendocrine cell survival.

1997 • 37 citations

PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein

2003 • 35 citations

Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1?24.3

1995 • 30 citations

Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells.

1996 • 27 citations

Genomic organization and alternative splicing of the human and mouse RPTPρ genes

2001 • 26 citations

Protein tyrosine phosphatases (PTPs) as drug targets: inhibitors of PTP-1B for the treatment of diabetes.

2000 • 26 citations

Gene estimate rises as US and UK discuss freedom of access

1999 • 23 citations

Isolation and Mapping of Human T-Cell Protein Tyrosine Phosphatase Sequences: Localization of Genes and Pseudogenes Discriminated Using Fluorescence Hybridization with Genomic versus cDNA Probes

1993 • 20 citations

Nuclear Localization of Non-receptor Protein Tyrosine Phosphatase ε Is Regulated by Its Unique N-Terminal Domain

2002 • 20 citations

Structural characterization and chromosomal localization of the mouse cDNA and gene encoding the bone tyrosine phosphatase, mOST-PTP

2000 • 16 citations

Chromosomal localization of an SH2 containing tyrosine phosphatase (SH-PTP3) gene to chromosome 12q24.1.

1994 • 13 citations

Transcriptional activation of the tyrosine phosphatase gene, OST‐PTP, during osteoblast differentiation

2002 • 13 citations

Major structural determinants of transmembrane proteins identified by principal component analysis

1999 • 11 citations

Parathyroid hormone regulates the expression of the receptor protein tyrosine phosphatase, OST-PTP, in rat osteoblast-like cells

1996 • 11 citations

Rat osteotesticular phosphatase gene ( Esp ): genomic structure and chromosome location

1999 • 8 citations

Histochemically demonstrable protein tyrosine phosphatase in human breast and colorectal cancer: large decrease in its activity in colorectal cancer suggests a tumor suppressor role in colorectal mucosal cells.

1996 • 7 citations

Bioinformatics: Protein Tyrosine Phosphatases

2003 • 1 citations