Functional analysis of PTPN11/SHP-2 mutants identified in Noonan syndrome and childhood leukemia

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1991 • 5,120 citations

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 • 1,678 citations

The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

2003 • 1,192 citations

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

2003 • 1,019 citations

Crystal Structure of the Tyrosine Phosphatase SHP-2

1998 • 940 citations

PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity

2002 • 765 citations

Activating Mutations of the Noonan Syndrome-Associated SHP2/PTPN11 Gene in Human Solid Tumors and Adult Acute Myelogenous Leukemia

2004 • 489 citations

Noonan syndrome: A review

1985 • 455 citations

Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis

2003 • 429 citations

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation

2004 • 414 citations

Noonan syndrome.

1987 • 304 citations

Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukemogenesis in childhood acute leukemia

2004 • 295 citations

Shp-2 Tyrosine Phosphatase: Signaling One Cell or Many

1999 • 291 citations

Multiple Requirements for SHPTP2 in Epidermal Growth Factor-Mediated Cell Cycle Progression

1996 • 247 citations

Genotype-phenotype correlations in Noonan syndrome

2004 • 245 citations

Noonan syndrome: The changing phenotype

1985 • 244 citations

A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.

1993 • 219 citations

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation

2004 • 183 citations

Spectrum of mutations in PTPN11 and genotype–phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome

2003 • 158 citations

Juvenile Myelomonocytic Leukemia and Noonan Syndrome

1999 • 152 citations

PI 3-kinase gamma and protein kinase C-zeta mediate RAS-independent activation of MAP kinase by a Gi protein-coupled receptor

1999 • 142 citations

Activated Mutants of SHP-2 Preferentially Induce Elongation of Xenopus Animal Caps

2000 • 117 citations

Protein-Tyrosine Phosphatase, Nonreceptor Type 11 Mutation Analysis and Clinical Assessment in 45 Patients with Noonan Syndrome

2004 • 112 citations

PTPN11(Protein-Tyrosine Phosphatase, Nonreceptor-Type 11) Mutations in Seven Japanese Patients with Noonan Syndrome

2002 • 112 citations

PTPN11 Mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13

2002 • 87 citations

Hepatocyte Growth Factor/c-Met Signaling Promotes the Progression of Experimental Human Neuroblastomas

2004 • 79 citations

Coordinate Regulation of STAT Signaling and c-fosExpression by the Tyrosine Phosphatase SHP-2

1998 • 62 citations

Insulin-Like Growth Factor System in Neuroblastoma Tumorigenesis and Apoptosis: Potential Diagnostic and Therapeutic Perspectives

1999 • 45 citations

Cas Mediates Transcriptional Activation of the Serum Response Element by Src

1999 • 45 citations

Increased susceptibility to ischemia‐induced brain damage in transgenic mice overexpressing a dominant negative form of SHP2

2000 • 42 citations

PTPN11 mutation in a large family with Noonan syndrome and dizygous twinning

2003 • 32 citations