Overview of protein serine/threonine phosphatases

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

2001 • 1,654 citations

A two-component system that regulates an osmosensing MAP kinase cascade in yeast

1994 • 1,091 citations

Protein phosphatase 1 – targeted in many directions

2002 • 911 citations

Regulation of the Calmodulin-stimulated Protein Phosphatase, Calcineurin

1998 • 892 citations

The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions

1998 • 820 citations

Regulation of protein kinase cascades by protein phosphatase 2A

1999 • 798 citations

THE STRUCTURE AND MECHANISM OF PROTEIN PHOSPHATASES: Insights into Catalysis and Regulation

1998 • 706 citations

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

1997 • 529 citations

Novel protein serine/threonine phosphatases: Variety is the spice of life

1997 • 503 citations

Inducible and Reversible Enhancement of Learning, Memory, and Long-Term Potentiation by Genetic Inhibition of Calcineurin

2001 • 464 citations

Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution.

1996 • 447 citations

p53-inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation

2000 • 416 citations

Molecular mechanisms of theprotein serine/threonine phosphatases

1996 • 365 citations

Combinatorial control of protein phosphatase-1

2001 • 293 citations

Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways

1998 • 292 citations

Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

2001 • 290 citations

Actions of PP2A on the MAP kinase pathway and apoptosis are mediated by distinct regulatory subunits

2002 • 268 citations

The Complement of Protein Phosphatase Catalytic Subunits Encoded in the Genome of Arabidopsis

2002 • 264 citations

Isoenzymes of Pyruvate Dehydrogenase Phosphatase

1998 • 212 citations

A Novel RNA Polymerase II C-terminal Domain Phosphatase That Preferentially Dephosphorylates Serine 5

2003 • 211 citations

Delayed embryonic lethality in mice lacking protein phosphatase 2A catalytic subunit Cα

1998 • 210 citations

Ptc1, a Type 2C Ser/Thr Phosphatase, Inactivates the HOG Pathway by Dephosphorylating the Mitogen-Activated Protein Kinase Hog1

2001 • 199 citations

An Unusual Eukaryotic Protein Phosphatase Required for Transcription by RNA Polymerase II and CTD Dephosphorylation in S. cerevisiae

1999 • 198 citations

The protein phosphatase 2C (PP2C) superfamily: Detection of bacterial homologues

1996 • 195 citations

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

1995 • 192 citations

Yeast Protein Serine/Threonine Phosphatases: Multiple Roles and Diverse Regulation

1996 • 192 citations

Protein kinases and protein phosphatases in prokaryotes: a genomic perspective

2002 • 191 citations

Protein phosphatase 2C (PP2C) function in higher plants.

1998 • 178 citations

Conservation analysis and structure prediction of the protein serine/threonine phosphatases

1994 • 177 citations

The SAPs, a New Family of Proteins, Associate and Function Positively with the SIT4 Phosphatase

1996 • 164 citations

Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases

1999 • 162 citations

Regulator‐driven functional diversification of protein phosphatase‐1 in eukaryotic evolution

2002 • 161 citations

Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control

2002 • 159 citations

Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase

1992 • 158 citations

The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation

1996 • 155 citations

Insulin Control of Glycogen Metabolism in Knockout Mice Lacking the Muscle-Specific Protein Phosphatase PP1G/R_GL

2001 • 154 citations

Protein phosphatase 5 in signal transduction

2001 • 151 citations

Regulation of the TAK1 Signaling Pathway by Protein Phosphatase 2C

2001 • 145 citations

An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae

1997 • 145 citations

The p21-Activated Kinase PAK Is Negatively Regulated by POPX1 and POPX2, a Pair of Serine/Threonine Phosphatases of the PP2C Family

2002 • 144 citations

Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1

2001 • 137 citations

Ser/Thr Protein Phosphatase Type 5 (PP5) Is a Negative Regulator of Glucocorticoid Receptor-Mediated Growth Arrest

1999 • 126 citations

Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription

2000 • 116 citations

Protein phosphatase 4 is an essential enzyme required for organisation of microtubules at centrosomes in Drosophila embryos

1998 • 115 citations

Protein Serine/Threonine Phosphatase Ptc2p Negatively Regulates the Unfolded-Protein Response by Dephosphorylating Ire1p Kinase

1998 • 114 citations

Selective suppression of stress‐activated protein kinase pathway by protein phosphatase 2C in mammalian cells

1998 • 103 citations

Molecular cloning and expression of the catalytic subunit of bovine pyruvate dehydrogenase phosphatase and sequence similarity with protein phosphatase 2C

1993 • 98 citations

Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters

1998 • 97 citations

Dephosphorylation of Human Cyclin-dependent Kinases by Protein Phosphatase Type 2Cα and β2 Isoforms

2000 • 96 citations

PTG gene deletion causes impaired glycogen synthesis and developmental insulin resistance

2003 • 96 citations

Protein phosphatase 4 is required for centrosome maturation in mitosis and sperm meiosis inC. elegans

2002 • 96 citations

The type 2C Ser/Thr phosphatase PP2Cγ is a pre-mRNA splicing factor

1999 • 90 citations

Rhodopsin activation causes retinal degeneration in drosophila rdgC mutant

1990 • 86 citations

Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A

2002 • 85 citations

Role of Ptc2 Type 2C Ser/Thr Phosphatase in Yeast High-Osmolarity Glycerol Pathway Inactivation

2002 • 83 citations

Disruption of the Striated Muscle Glycogen Targeting Subunit PPP1R3A of Protein Phosphatase 1 Leads to Increased Weight Gain, Fat Deposition, and Development of Insulin Resistance

2003 • 82 citations

Purification and Identification of a Novel Subunit of Protein Serine/Threonine Phosphatase 4

1999 • 81 citations

Purification and Characterization of an RNA Polymerase II Phosphatase from Yeast

1996 • 76 citations

Mutations in the protein phosphatase 1 gene at 87B can differentially affect suppression of position-effect variegation and mitosis in Drosophila melanogaster.

1993 • 75 citations

Protein phosphatase 1 activity in Drosophila mutants with abnormalities in mitosis and chromosome condensation

1990 • 74 citations

Protein phosphatase 2C dephosphorylates and inactivates cystic fibrosis transmembrane conductance regulator

1997 • 73 citations

Molecular cloning and primary structure of a protein phosphatase 2C isoform

1992 • 72 citations

Embryonic Morphogenesis in Caenorhabditis elegans Integrates the Activity of LET-502 Rho-Binding Kinase, MEL-11 Myosin Phosphatase, DAF-2 Insulin Receptor and FEM-2 PP2c Phosphatase

2000 • 66 citations

Mammalian protein serine/threonine phosphatase 2C: cDNA cloning and comparative analysis of amino acid sequences

1992 • 64 citations

FIN13, a Novel Growth Factor-Inducible Serine-Threonine Phosphatase Which Can Inhibit Cell Cycle Progression

1997 • 61 citations

Molecular Evolution of Type 1 Serine/Threonine Protein Phosphatases

1999 • 57 citations

The Caenorhabditis elegansSex-determining Protein FEM-2 and Its Human Homologue, hFEM-2, Are Ca2+/Calmodulin-dependent Protein Kinase Phosphatases That Promote Apoptosis

2001 • 54 citations

Molecular Cloning of Ca2+/Calmodulin-Dependent Protein Kinase Phosphatase

1999 • 51 citations

RdgC/PP5-Related Phosphatases

1999 • 45 citations

Molecular Enzymology Underlying Regulation of Protein Phosphatase-1 by Natural Toxins

2002 • 44 citations

The cloning expression and tissue distribution of human PP2Cβ¹

1998 • 26 citations

A Novel Phosphatase Regulating Neurite Extension on CNS Inhibitors

1998 • 22 citations

Protein histidine phosphatase activity in rat liver and spinach leaves

1995 • 20 citations

Inhibitor-1 Is Not Required for the Activation of Glycogen Synthase by Insulin in Skeletal Muscle

1999 • 19 citations

Protein Serine/Threonine Phosphatases and the PPP Family

2003 • 5 citations