Nerve Growth Factor: Actions in the Peripheral and Central Nervous Systems

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation

1983 • 3,028 citations

Oncogenes and signal transduction

1991 • 2,816 citations

Central cholinergic pathways in the rat: An overview based on an alternative nomenclature (Ch1–Ch6)

1983 • 2,305 citations

ERKs: A family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF

1991 • 1,901 citations

Fos and jun: The AP-1 connection

1988 • 1,597 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections

1986 • 1,458 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Regressive Events in Neurogenesis

1984 • 1,330 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3

1991 • 1,078 citations

Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection.

1986 • 1,063 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Proliferation, differentiation and degeneration in the spinal ganglia of the chick embryo under normal and experimental conditions

1949 • 974 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1951 • 947 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

Nerve Growth Factor Treatment After Brain Injury Prevents Neuronal Death

1987 • 942 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons

1989 • 934 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

1991 • 887 citations

trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

1991 • 830 citations

Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin

1985 • 824 citations

Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases

1990 • 767 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Local control of neurite development by nerve growth factor

1977 • 732 citations

NGF-Mediated increase of choline acetyltransferase (ChAT) in the neonatal rat forebrain: Evidence for a physiological role of NGF in the brain?

1983 • 725 citations

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

1990 • 720 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Binding of brain-derived neurotrophic factor to the nerve growth factor receptor

1990 • 702 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM

1960 • 692 citations

Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture

1990 • 684 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat

1985 • 676 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Nerve growth factors (NGF, BDNF) enhance axonal regeneration but are not required for survival of adult sensory neurons

1988 • 657 citations

Destruction of the sympathetic ganglia in mammals by an antiserum to a nerve-growth protein

1960 • 651 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

Limbic Seizures Increase Neuronal Production of Messenger RNA for Nerve Growth Factor

1989 • 624 citations

An immunohistochemical study of the nerve growth factor receptor in developing rats

1988 • 610 citations

Binding of apotransferrin to K562 cells: explanation of the transferrin cycle.

1983 • 603 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

1987 • 555 citations

The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

1991 • 530 citations

Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons

1990 • 529 citations

Studies on the expression of the beta nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons.

1986 • 528 citations

Development and regional expression of beta nerve growth factor messenger RNA and protein in the rat central nervous system.

1986 • 525 citations

Neuronal Chemotaxis: Chick Dorsal-Root Axons Turn Toward High Concentrations of Nerve Growth Factor

1979 • 522 citations

Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.

1984 • 519 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

1990 • 508 citations

New protein fold revealed by a 2.3-Å resolution crystal structure of nerve growth factor

1991 • 500 citations

Dorsal Root Ganglion Neurons Are Destroyed by Exposure in Utero to Maternal Antibody to Nerve Growth Factor

1980 • 500 citations

Characterization of the turning response of dorsal root neurites toward nerve growth factor.

1980 • 487 citations

ACUTE REGULATION OF TYROSINE HYDROXYLASE BY NERVE ACTIVITY AND BY NEUROTRANSMITTERS VIA PHOSPHORYLATION

1989 • 487 citations

Choline Acetyltransferase Activity in Striatum of Neonatal Rats Increased by Nerve Growth Factor

1985 • 483 citations

Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body

1990 • 452 citations

In Vitro Experiments on the Effects of Mouse Sarcomas 180 and 37 on the Spinal and Sympathetic Ganglia of the Chick Embryo

1997 • 449 citations

Nerve Growth Factor Gene Expression in the Developing Rat Brain

1986 • 436 citations

Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor

1981 • 407 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Distribution of neuronal receptors for nerve growth factor in the rat

1986 • 398 citations

Naturally Occurring Neuronal Death in Vertebrates

1990 • 389 citations

Microtubule‐associated‐protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells

1990 • 386 citations

POLYPEPTIDE GROWTH FACTORS

1984 • 381 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

An Enzyme‐Linked Immunoassay for Nerve Growth Factor (NGF): A Tool for Studying Regulatory Mechanisms Involved in NGF Production in Brain and in Peripheral Tissues

1987 • 377 citations

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

1986 • 377 citations

Characterization of the MRC OX40 antigen of activated CD4 positive T lymphocytes--a molecule related to nerve growth factor receptor.

1990 • 375 citations

Relationship between levels of nerve growth factor (NGF) and its messenger RNA in sympathetic ganglia and peripheral target tissues.

1984 • 359 citations

Induction of the proto-oncogene fos by nerve growth factor.

1985 • 359 citations

A diffusible agent of mouse sarcoma, producing hyperplasia of sympathetic ganglia and hyperneurotization of viscera in the chick embryo

1953 • 359 citations

Expression of the β-Nerve Growth Factor Gene in Hippocampal Neurons

1988 • 356 citations

Acidic and basic fibroblast growth factors promote stable neurite outgrowth and neuronal differentiation in cultures of PC12 cells

1987 • 353 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

Cellular localization of nerve growth factor synthesis by in situ hybridization.

1987 • 345 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Nerve growth factor mRNA in peripheral and central rat tissues and in the human central nervous system: Lesion effects in the rat brain and levels in Alzheimer's disease

1986 • 335 citations

Dynein is the motor for retrograde axonal transport of organelles.

1989 • 334 citations

Expression of nerve growth factor receptor mRNA is developmentally regulated and increased after axotomy in rat spinal cord motoneurons

1989 • 331 citations

Morphological response of axotomized septal neurons to nerve growth factor

1988 • 323 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

Nerve growth factor protects adult sensory neurons from cell death and atrophy caused by nerve injury

1987 • 316 citations

Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.

1990 • 314 citations

Morphometric analysis of rat superior cervical ganglion after axotomy and nerve growth factor treatment

1976 • 311 citations

A NERVE GROWTH-STIMULATING FACTOR ISOLATED FROM SNAKE VENOM

1956 • 309 citations

Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene

1985 • 306 citations

Naturally Occurring Neuron Death and Its Regulation by Developing Neural Pathways

1982 • 306 citations

Expression and possible function of nerve growth factor receptors on Schwann cells

1988 • 304 citations

Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

1981 • 302 citations

Keeping track of neurotrophin receptors

1991 • 297 citations

Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors

1991 • 296 citations

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor

1991 • 288 citations

Pharmacological effects of nerve growth factor and fibroblast growth factor applied to the transectioned sciatic nerve on neuron death in adult rat dorsal root ganglia

1987 • 285 citations

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

1990 • 282 citations

Kainic acid-induced seizures stimulate increased expression of nerve growth factor mRNA in rat hippocampus

1991 • 280 citations

Chemotactic response of nerve fiber elongation to nerve growth factor

1978 • 279 citations

Nerve growth factor infusion in the primate brain reduces lesion- induced cholinergic neuronal degeneration

1990 • 278 citations

Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma 1 by a kinase activity associated with the product of the trk protooncogene.

1991 • 272 citations

Demonstration of the retrograde transport of nerve growth factor receptor in the peripheral and central nervous system

1987 • 268 citations

Nerve growth factor counteracts the neurophysiological and neurochemical effects of chronic sciatic nerve section

1985 • 268 citations

Evidence that endogenous beta nerve growth factor is responsible for the collateral sprouting, but not the regeneration, of nociceptive axons in adult rats.

1987 • 265 citations

Implantation of tumors in the hind limb field of the embryonic chick and the developmental response of the lumbosacral nervous system

1948 • 263 citations

Nerve growth factor increases mRNA levels for the prion protein and the beta-amyloid protein precursor in developing hamster brain.

1988 • 254 citations

The trk proto-oncogene rescues NGF responsiveness in mutant NGF-nonresponsive PC12 cell lines

1991 • 252 citations

Basic FGF induces neuronal differentiation, cell division, and NGF dependence in chromaffin cells: A sequence of events in sympathetic development

1988 • 252 citations

Developmental and regional expression of β-nerve growth factor receptor mRNA in the chick and rat

1988 • 245 citations

NGF receptor reexpression and NGF-mediated cholinergic neuronal hypertrophy in the damaged adult neostriatum

1989 • 241 citations

Insulin growth factors regulate the mitotic cycle in cultured rat sympathetic neuroblasts.

1988 • 239 citations

Nerve growth activities in rat peripheral nerve

1982 • 235 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

Retrograde cell changes in medial septum and diagonal band following fimbria-fornix transection: Quantitative temporal analysis

1986 • 235 citations

Delayed treatment with nerve growth factor reverses the apparent loss of cholinergic neurons after acute brain damage

1988 • 233 citations

Nerve growth factor regulates sympathetic ganglion cell morphology and survival in the adult mouse

1990 • 227 citations

Relation of target encounter and neuronal death to nerve growth factor responsiveness in the developing mouse trigeminal ganglion

1984 • 225 citations

Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers

1984 • 223 citations

Specificity of retrograde transport of nerve growth factor (NGF) in sensory neurons: A biochemical and morphological study

1975 • 221 citations

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

1990 • 221 citations

Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells

1989 • 219 citations

Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers

1983 • 218 citations

Nerve growth factor enhances regeneration through silicone chambers

1989 • 216 citations

NGF gene expression in actively growing brain glia

1991 • 210 citations

The Death Programme in Cultured Sympathetic Neurones Can Be Suppressed at the Posttranslational Level by Nerve Growth Factor, Cyclic AMP, and Depolarization

1991 • 202 citations

Phosphoinositide kinase, diacylglycerol kinase, and phospholipase C activities associated to the cytoskeleton: effect of epidermal growth factor.

1991 • 202 citations

Molecular characteristics of nerve growth factor receptors on PC12 cells.

1985 • 200 citations

Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

1984 • 197 citations

Quantitative demonstration of the retrograde axonal transport of endogenous nerve growth factor

1983 • 195 citations

Evidence for a physiological role of nerve growth factor in the central nervous system of neonatal rats

1989 • 195 citations

Basal forebrain magnocellular neurons stain for nerve growth factor receptor: Correlation with cholinergic cell bodies and effects of axotomy

1987 • 193 citations

A novel modular mosaic of cell adhesion motifs in the extracellular domains of the neurogenic trk and trkB tyrosine kinase receptors.

1991 • 193 citations

Nerve growth factor is a mitogen for cultured chromaffin cells

1985 • 192 citations

ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons

1989 • 192 citations

Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease.

1992 • 185 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

1991 • 184 citations

Dependence of Kidney Morphogenesis on the Expression of Nerve Growth Factor Receptor

1991 • 184 citations

Retrograde axonal transport of specific macromolecules as a tool for characterizing nerve terminal membranes

1979 • 183 citations

Differential effects of NGF, FGF, EGF, cAMP, and dexamethasone on neurite outgrowth and sodium channel expression in PC12 cells

1990 • 181 citations

Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons.

1981 • 180 citations

Dissecting the Mode of Action of a Neuronal Growth Factor

1991 • 179 citations

Regulation of neural cell adhesion molecule expression on cultured mouse Schwann cells by nerve growth factor.

1987 • 177 citations

Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent neural crest cells

1991 • 176 citations

Characterization of the binding properties and retrograde axonal transport of a monoclonal antibody directed against the rat nerve growth factor receptor.

1985 • 175 citations

Sympathetic nerve fibers ingrowth in the central nervous system of neonatal rodent upon intracerebral NGF injections.

1978 • 173 citations

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

1989 • 171 citations

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey

1990 • 170 citations

Localization of nerve growth factor receptor messenger RNA and protein in the adult rat brain

1989 • 169 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells

1991 • 168 citations

Histochemical characterization of sensory neurons with high-affinity receptors for nerve growth factor

1989 • 165 citations

The spatial and temporal pattern of beta NGF receptor expression in the developing chick embryo.

1985 • 163 citations

Effect of exposure to anti-NGF on sensory neurons of adult rats and guinea pigs

1982 • 163 citations

NGF receptor-mediated reduction in axonal NGF uptake and retrograde transport following sciatic nerve injury and during regeneration

1991 • 161 citations

NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease

1989 • 160 citations

NGF and excitatory neurotransmitters regulate survival and morphogenesis of cultured cerebellar Purkinje cells

1991 • 160 citations

Developmentally regulated expression of the nerve growth factor receptor gene in the periphery and brain.

1987 • 157 citations

Molecular investigations on the high-affinity nerve growth factor receptor

1991 • 154 citations

The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation.

1991 • 153 citations

Developmental changes of nerve growth factor and its mRNA in the rat hippocampus: Comparison with choline acetyltransferase

1987 • 152 citations

Role of nerve growth factor in the adult dorsal root ganglia neuron and its response to injury

1984 • 152 citations

Cell division in the developing sympathetic nervous system

1977 • 151 citations

Retrograde transport of nerve growth factor (NGF) in motoneurons of developing rats: Assessment of potential neurotrophic effects

1988 • 151 citations

A reappraisal of the functions of the nucleus basalis of Meynert

1988 • 151 citations

Localization and development of nerve growth factor-sensitive rat basal forebrain neurons and their afferent projections to hippocampus and neocortex

1989 • 149 citations

Activated N‐ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells

1986 • 149 citations

Development of the rat superior cervical ganglion: ganglion cell maturation

1985 • 147 citations

Developmental changes of nerve growth factor levels in sympathetic ganglia and their target organs

1988 • 145 citations

Immunohistochemical localization and biochemical characterization of nerve growth factor receptor in adult rat brain

1989 • 143 citations

Target attraction: Are developing axons guided by chemotropism?

1991 • 142 citations

Correlation between GAP43 and nerve growth factor receptors in rat sensory neurons

1990 • 140 citations

Nerve Growth Factor Regulates Expression of the Nerve Growth Factor Receptor Gene in Adult Sensory Neurons

1990 • 136 citations

Regulation of axonal caliber, neurofilament content, and nuclear localization in mature sensory neurons by nerve growth factor

1991 • 136 citations

Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression.

1989 • 134 citations

Nerve Growth Factor Induces the Proto-oncogene c-jun in PC12 Cells

1989 • 134 citations

Induction by NGF of Meiotic Maturation of Xenopus Oocytes Expressing the trk Proto-Oncogene Product

1991 • 133 citations

Epidermal growth factor receptors associated to cytoskeletal elements of epidermoid carcinoma (A431) cells.

1986 • 133 citations

Characterization of the retrograde transport of nerve growth factor (NGF) using high specific activity [125I]NGF

1978 • 131 citations

Nerve Growth Factor

1977 • 130 citations

Developmental neuron death in the rat superior cervical sympathetic ganglion: cell counts and ultrastructure

1983 • 127 citations

Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen

1989 • 126 citations

Nerve growth factor stimulates the hydrolysis of glycosylphosphatidylinositol in PC-12 cells: a mechanism of protein kinase C regulation.

1989 • 126 citations

Uptake of nerve growth factor along peripheral and spinal axons of primary sensory neurons

1984 • 125 citations

Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro

1988 • 122 citations

Biochemical and anatomical effects of antibodies against nerve growth factor on developing rat sensory ganglia.

1984 • 122 citations

Structure and expression of the chicken beta nerve growth factor gene.

1986 • 121 citations

Regulation of nerve growth factor receptor gene expression by nerve growth factor in the developing peripheral nervous system.

1991 • 121 citations

Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms.

1990 • 121 citations

Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells

1990 • 120 citations

NGF effects on developing forebrain cholinergic neurons are regionally specific

1987 • 120 citations

Structure and developmental expression of the chicken NGF receptor

1990 • 120 citations

Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients

1989 • 118 citations

Nerve growth factor and fibroblast growth factor selectively activate a protein kinase that phosphorylates high molecular weight microtubule-associated proteins. Detection, partial purification, and characterization in PC12 cells.

1990 • 116 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells.

1988 • 115 citations

Multiple autophosphorylation site mutations of the epidermal growth factor receptor. Analysis of kinase activity and endocytosis

1991 • 114 citations

Expression of the NGF receptor gene in sensory neurons and their cutaneous targets prior to and during innervation

1990 • 113 citations

Treatment with 6-hydroxydopamine and colchicine decreases nerve growth factor levels in sympathetic ganglia and increases them in the corresponding target tissues

1985 • 111 citations

Chimeric molecules with multiple neurotrophic activities reveal structural elements determining the specificities of NGF and BDNF.

1991 • 111 citations

Nerve growth factor mRNA in brain: Localization by in situ hybridization

1986 • 110 citations

Immunohistochemical localization of cells containing nerve growth factor receptors in the different regions of the adult rat forebrain

1988 • 108 citations

Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of Schwannoma and other conditioned media

1982 • 108 citations

Nerve growth factor-induced neuronal differentiation after dominant repression of both type I and type II cAMP-dependent protein kinase activities

1991 • 106 citations

Nerve growth factor-independent development of embryonic mouse sympathetic neurons in dissociated cell culture

1985 • 104 citations

Nerve growth factor has both mitogenic and antimitogenic activity

1982 • 103 citations

Inhibition of protein synthesis prevents cell death in sensory and parasympathetic neurons deprived of neurotrophic factor in vitro

1990 • 103 citations

[3] Assaying binding of nerve growth factor to cell surface receptors

1985 • 102 citations

The Mechanism of Action of Nerve Growth Factor

1991 • 102 citations

Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase.

1989 • 101 citations

Expression of growth factor receptors in injured nervous tissue. I. Axotomy leads to a shift in the cellular distribution of specific β-nerve growth factor binding in the injured and regenerating PNS

1987 • 98 citations

The internalization of nerve growth factor by high-affinity receptors on pheochromocytoma PC12 cells.

1987 • 98 citations

NGF Amplifies Expression of NGF Receptor Messenger RNA in Forebrain Cholinergic Neurons of Rats

1989 • 97 citations

Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding.

1990 • 94 citations

Biochemical effects of antibodies against nerve growth factor on developing and differentiated sympathetic ganglia

1978 • 94 citations

Short- and long-term effects of nerve growth factor on the sympathetic nervous system in the adult mouse

1975 • 91 citations

Neuronal growth factors produced by adult peripheral nerve after injury

1986 • 89 citations

Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines

1991 • 88 citations

Cell-free detection and characterization of a novel nerve growth factor-activated protein kinase in PC12 cells.

1987 • 88 citations

Nerve growth factor regulates gene expression by several distinct mechanisms.

1989 • 86 citations

Sciatic nerve regeneration across gaps within silicone chambers: Long-term effects of NGF and consideration of axonal branching

1990 • 86 citations

Factors influencing GAP-43 gene expression in PC12 pheochromocytoma cells

1990 • 85 citations

Neuronotrophic effect of developing otic vesicle on cochleo-vestibular neurons: evidence for nerve growth factor involvement

1990 • 85 citations

Separate endocytic pathways of kinase-defective and -active EGF receptor mutants expressed in same cells.

1990 • 84 citations

The synthesis of nerve growth factor (NGF) in developing skin is independent of innervation

1988 • 84 citations

Ligand‐induced association of epidermal growth factor receptor to the cytoskeleton of A431 cells

1989 • 82 citations

Differential regulation of the low‐affinity nerve growth factor receptor during postnatal development of the rat brain

1991 • 81 citations

Loss of AChE- and NGFr-labeling precedes neuronal death of axotomized septal-diagonal band neurons: Reversal by intraventricular NGF infusion

1991 • 75 citations

Nerve growth factor enhances neurite arborization of adult sensory neurons; a study i single-cell culture

1990 • 73 citations

Nerve growth factor effects on cholinergic neurons of neostriatum and nucleus accumbens in the adult rat

1989 • 71 citations

Nerve growth factor treatment or cAMP elevation reduces Ca2+/calmodulin-dependent protein kinase III activity in PC12 cells.

1987 • 70 citations

Embryologic development of a mouse sympathetic ganglion in vivo and in vitro.

1977 • 68 citations

Phosphorylation of the peripherin 58-kDa neuronal intermediate filament protein

1989 • 68 citations

Alterations in the fine structure of nucleoli in sympathetic neurons following NGF-antiserum treatment

1969 • 66 citations

Expression of high- and low-affinity nerve growth factor receptors by Purkinje cells in the developing rat cerebellum

1989 • 65 citations

Recombinant human nerve growth factor is biologically active and labels novel high-affinity binding sites in rat brain.

1991 • 64 citations

Regulation of nerve growth factor mRNA levels in developing rat heart ventricle is not altered by sympathectomy

1989 • 63 citations

The effects of nerve growth factor (NGF) and antiserum to NGF on the development of embryonic sympathetic neurons in vivo

1980 • 63 citations

Nerve growth factor and the peptidergic sensory neurons

1984 • 63 citations

Nerve growth factor stimulates protein tyrosine phosphorylation in PC-12 pheochromocytoma cells.

1991 • 62 citations

Ultrastructural changes in sympathetic neurons of newborn and adult mice treated with nerve growth factor

1971 • 60 citations

NGF-induced remodeling of mature uninjured axon collaterals

1990 • 60 citations

Monoamines in immunosympathectomized rats

1965 • 60 citations

Nerve growth factor binding domain of the nerve growth factor receptor.

1991 • 59 citations

The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides.

1990 • 57 citations

The genes encoding nerve growth factor and its receptor are expressed in the developing female rat hypothalamus

1991 • 57 citations

Production of 1,2‐Diacylglycerol in PC12 Cells by Nerve Growth Factor and Basic Fibroblast Growth Factor

1990 • 57 citations

Nerve growth factor-mediated induction of choline acetyltransferase in PC12 cells: evaluation of the site of action of nerve growth factor and the involvement of lysosomal degradation products of nerve growth factor

1984 • 57 citations

Association of nerve growth factor receptors with the triton X-100 cytoskeleton of PC12 cells

1985 • 56 citations

Differentiation of PC12 cells with v‐src: Comparison with nerve growth factor

1989 • 55 citations

Detection of nerve growth factor and epidermal growth factor-regulated protein kinases in PC12 cells with synthetic peptide substrates.

1989 • 55 citations

Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.

1991 • 55 citations

Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.

1992 • 54 citations

Neurotrophins: structural relatedness and receptor interactions

1991 • 54 citations

Early effects of antiserum against the nerve growth factor on fine structure of sympathetic neurons

1965 • 52 citations

NGF-induction of the metalloproteinase-transin/stromelysin in PC12 cells: involvement of multiple protein kinases.

1991 • 48 citations

ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells.

1991 • 48 citations

Nerve Growth Factor in Neuronal Development and Maintenance

1987 • 45 citations

Selective Inhibition of Nerve Growth Factor‐Stimulated Protein Kinases by K‐252a and 5′‐S‐Methyladenosine in PC12 Cells

1989 • 45 citations

Synapsin I in PC12 cells. II. Evidence for regulation by NGF of phosphorylation at a novel site

1987 • 44 citations

Correlative decrease of large neurons in the neostriatum and basal nucleus of Meynert in Alzheimer's disease

1989 • 41 citations

Nerve growth factor rapidly stimulates arachidonate metabolism in PC12 cells: Potential involvement in nerve fiber growth

1988 • 41 citations

Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients

1989 • 41 citations

Molecular studies in Alzheimer's disease

1991 • 40 citations

Epidermal growth factor receptor expression during morphological differentiation of pheochromocytoma cells, induced by nerve growth factor or dibutyryl cyclic AMP

1987 • 38 citations

Nerve Growth Factor‐Induced Down‐Regulation of Calmodulin‐Dependent Protein Kinase III in PC12 Cells Involves Cyclic AMP‐Dependent Protein Kinase

1990 • 37 citations

Developmental study of nerve growth factor receptor mRNA expression in the postnatal rat cerebellum

1990 • 36 citations

Evidence that certain peripheral anti-acetylcholine receptor antibodies do not interact with brain BuTX binding sites

1983 • 35 citations

Immunohistochemical evidence for the distribution of nerve growth factor in the embryonic mouse

1987 • 34 citations

The response of cultured trigeminal and spinal cord motoneurons to nerve growth factor

1990 • 34 citations

Immunosympathectomy: Lack of evidence for a complement-mediated cytotoxic mechanism

1980 • 33 citations

Nerve Growth Factor Stimulation of Arachidonic Acid Release from PC12 Cells: Independence from Phosphoinositide Turnover

1990 • 32 citations

Analysis of local cholinergic tremor mechanisms following selective neurochemical lesions

1970 • 31 citations

Multiple Pathways of N‐Kinase Activation in PC12 Cells

1990 • 31 citations

Analytical purification of the slow, high affinity NGF receptor: Identification of a novel 135 kd polypeptide

1991 • 29 citations

Developmental expression of the chicken nerve growth factor receptor gene during brain morphogenesis

1989 • 28 citations

Nerve growth factor induces rapid redistribution of F‐actin in PC12 cells

1988 • 28 citations

The Differential Role of Protein Kinase C Isozyme in the Rapid Induction of Neurofilament Phosphorylation by Nerve Growth Factor and Phorbol Esters in PC12 Cells

1991 • 26 citations

Relationship among types of nerve growth factor receptors on PC12 cells.

1990 • 26 citations

On the development of the sympathetic chain and the adrenal medulla in the mouse

1971 • 26 citations

Induction of ornithine decarboxylase by nerve growth factor in PC12 cells: dissection by purine analogues.

1990 • 26 citations

The roles of macromolecular synthesis and phosphorylation in the regulation of a protein kinase activity transiently stimulated by nerve growth factor

1991 • 25 citations

Nerve growth factor increases the cyclic GMP level and activates the cyclic GMP phosphodiesterase in PC12 cells

1988 • 23 citations

Nerve Growth Factor Potentiates the Hormone‐Stimulated Intracellular Accumulation of Inositol Phosphates and Ca²⁺ in Rat PC12 Pheochromocytoma Cells: Comparison with the Effect of Epidermal Growth Factor

1989 • 23 citations

Temporal pattern of nerve growth factor receptor expression in developing cochlear and vestibular ganglia in quail and mouse

1991 • 22 citations

The ontogeny of specific retrograde transport of nerve growth factor by motoneurons of the brainstem and spinal cord

1990 • 22 citations

Microinjection of a p21ras Antibody into PC12 Cells Inhibits Neurite Outgrowth Induced by Nerve Growth Factor and Basic Fibroblast Growth Factor

1991 • 19 citations

Nerve Growth Factor (NGF) Responses by Non-Neuronal Cells: Detection by Assay of a Novel NGF-Activated Protein Kinase

1990 • 18 citations

Characterization of nerve growth factor binding to embryonic rat spinal cord neurons

1990 • 15 citations

Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts

1989 • 12 citations

NGF-induced alternations in protein secretion and substrate-attached material of a clonal nerve cell line

1978 • 12 citations

Nerve growth factor in Alzheimer's disease: To treat or not to treat?

1989 • 11 citations

The role of striatal cholinergic mechanisms for the development of limb rigidity: An electromyographic study in rats

1986 • 11 citations

The influence of nerve growth factor on the activities of adenylate cyclase and high‐affinity GTPase in pheochromocytoma PC12 cells

1989 • 8 citations

Effects of NGF-antiserum in sympathetic neurons during early postnatal development

1972 • 7 citations