Molecular studies in Alzheimer's disease

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Mutation of the Alzheimer's Disease Amyloid Gene in Hereditary Cerebral Hemorrhage, Dutch Type

1990 • 1,361 citations

Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

1989 • 1,237 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Alzheimer's Disease

1986 • 772 citations

Tau protein function in living cells.

1986 • 727 citations

Secreted form of amyloid β protein precursor is involved in the growth regulation of fibroblasts

1989 • 477 citations

Amyloid β Protein Enhances the Survival of Hippocampal Neurons in Vitro

1989 • 470 citations

Amyloid β Protein Precursor Gene and Hereditary Cerebral Hemorrhage with Amyloidosis (Dutch)

1990 • 466 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

Expression of β amyloid protein precursor mRNAs: Recognition of a novel alternatively spliced form and quantitation in alzheimer's disease using PCR

1990 • 426 citations

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

1990 • 396 citations

Expression of the Alzheimer amyloid precursor gene transcripts in the human brain

1988 • 386 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

New Perspectives on Alzheimer's Disease

1986 • 349 citations

The promoter of Alzheimer's disease amyloid A4 precursor gene.

1988 • 309 citations

Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease

1988 • 254 citations

Genomic organization of the human amyloid beta-protein precursor gene

1990 • 248 citations

Relation of Neuronal APP-751/APP-695 mRNA Ratio and Neuritic Plaque Density in Alzheimer's Disease

1990 • 248 citations

Molecular definition of a region of chromosome 21 that causes features of the Down syndrome phenotype.

1990 • 241 citations

Mouse nerve growth factor prevents degeneration of axotomized basal forebrain cholinergic neurons in the monkey

1990 • 170 citations

Deciphering Alzheimer's Disease: The Amyloid Precursor Protein Yields New Clues

1990 • 140 citations

The PreA4₆₉₅precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons

1989 • 123 citations

Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates

1990 • 121 citations

Nerve growth factor infusions combined with fetal hippocampal grafts enhance reconstruction of the lesioned septohippocampal projection

1990 • 113 citations

Down syndrome, Alzheimer's disease and the trisomy 16 mouse

1988 • 88 citations

The protease inhibitory properties of the Alzheimer's beta-amyloid precursor protein.

1990 • 87 citations

Tau protein: An update on structure and function

1990 • 78 citations

Molecular genetic approaches to Alzheimer's disease

1989 • 65 citations

Unraveling prion diseases through molecular genetics

1989 • 46 citations

Along the Way to a Neurofibrillary Tangle: A Look at the Structure of Tau

1989 • 30 citations

Nerve growth factor in Alzheimer's disease: To treat or not to treat?

1989 • 11 citations