Association of 125I-nerve growth factor with PC12 pheochromocytoma cells. Evidence for internalization via high-affinity receptors only and for long-term regulation by nerve growth factor of both high- and low-affinity receptors.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Nerve growth factor.

1968 • 2,025 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells.

1980 • 798 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

Local control of neurite development by nerve growth factor

1977 • 732 citations

PC12 Pheochromocytoma Cultures in Neurobiological Research

1982 • 728 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

Reconstituted rattail collagen used as substrate for tissue cultures on coverslips in Maximow slides and roller tubes.

1958 • 660 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

The retrograde axonal transport of nerve growth factor

1974 • 598 citations

RESOLUTION IN ELECTRON MICROSCOPE RADIOAUTOGRAPHY

1969 • 433 citations

AUTORADIOGRAPHY WITH THE ELECTRON MICROSCOPE

1964 • 375 citations

Trophic Mechanisms in the Peripheral Nervous System

1978 • 326 citations

The Biology and Mechanism of Action of Nerve Growth Factor

1982 • 324 citations

Nerve growth factor receptors on PC12 cells: Evidence for two receptor classes with differing cytoskeletal association

1981 • 302 citations

Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states.

1980 • 255 citations

Nerve Growth Factor

1978 • 243 citations

A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands

1981 • 236 citations

A quantitative bioassay for nerve growth factor (NGF) activity employing a clonal pheochromocytoma cell line

1977 • 192 citations

Nerve growth factor in the nucleus: interaction with receptors on the nuclear membrane.

1979 • 191 citations

Binding of Nerve Growth Factor Receptor in Sympathetic Ganglia

1973 • 180 citations

Biological importance of retrograde axonal transport of nerve growth factor in adrenergic neurons

1975 • 161 citations

Rapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factor

1979 • 146 citations

Internalized insulin receptors are recycled to the cell surface in rat hepatocytes.

1982 • 142 citations

Binding, internalization, and retrograde transport of 125I-nerve growth factor in cultured rat sympathetic neurons

1982 • 141 citations

Mobility, clustering, and transport of nerve growth factor in embryonal sensory cells and in a sympathetic neuronal cell line.

1980 • 140 citations

A second messenger required for nerve growth factor biological activity?

1981 • 132 citations

Alteration of binding properties and cytoskeletal attachment of nerve growth factor receptors in PC12 cells by wheat germ agglutinin.

1982 • 98 citations

Sequestration of 125I-labeled beta nerve growth factor by sympathetic neurons.

1980 • 89 citations

Nerve growth factor-induced differentiation of PC12 cells: evaluation of changes in RNA and DNA metabolism

1981 • 86 citations

Proteins in the nervous system — structure and function

1982 • 80 citations

A novel assay of neuronal cell adhesion

1975 • 68 citations

Pit formation and rapid changes in surface morphology of sympathetic neurons in response to nerve growth factor.

1981 • 67 citations

Retrograde transport of nerve growth factor in chicken embryo.

1979 • 65 citations

Specific binding sites for 125I-nerve growth factor in peripheral tissues and brain

1974 • 60 citations

Localization of nerve growth factor bound to neurons growing nerve fibers in culture

1982 • 54 citations

The effect of the retrograde axonal transport of nerve growth factor on the morphology of adrenergic neurones

1977 • 50 citations

A comparison of binding properties and structure of NGF receptor on PC12 pheochromocytoma and A875 melanoma cells

1983 • 48 citations

Interactions of low density lipoprotein receptors with coated pits on human fibroblasts: estimate of the forward rate constant and comparison with the diffusion limit.

1981 • 47 citations

Binding constants of isolated NGF-receptors from different species

1983 • 47 citations

Internalization of nerve growth factor by pheochromocytoma PC12 cells: absence of transfer to the nucleus

1982 • 47 citations

Interaction of nerve growth factor with pheochromocytoma cells. Evidence for tight binding and sequestration

1980 • 46 citations

Electron microscopic radioautographic localization of iodinated nerve growth factor bound to and internalized by PC12 cells

1983 • 43 citations

Nerve growth factor receptors: analysis of the interaction of ßNGF with membranes of chick embryo dorsal root ganglia

1980 • 36 citations

The Nerve Growth Factor Receptor on PC 12 Cells: Interconversion Between Two Forms with Different Binding Properties

1983 • 35 citations

Endocytosis of nerve growth factor by PC12 cells studied by quantitative ultrastructural autoradiography

1982 • 27 citations

Binding, sequestration, and processing of epidermal growth factor and nerve growth facor by PC12 cells

1983 • 26 citations

Sequestration requirements for the degradation of ¹²⁵I‐labeled β nerve growth factor bound to embryonic sensory neurons

1982 • 14 citations

Characteristics of the association of nerve growth factor with primary cultures of rat sympathetic neurons

1982 • 9 citations

Receptor interactions of nerve growth factor.

1981 • 3 citations