The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Translational Findings on Brain-Derived Neurotrophic Factor and Anxiety: Contributions from Basic Research to Clinical Practice

2013 • 3,921 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Purification of a new neurotrophic factor from mammalian brain.

1982 • 1,762 citations

A Manual of Methods for Baculovirus Vectors and Insect Cell Culture Procedures.

1987 • 1,703 citations

Molecular cloning and expression of brain-derived neurotrophic factor

1989 • 1,453 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

NT-3, BDNF, and NGF in the developing rat nervous system: Parallel as well as reciprocal patterns of expression

1990 • 1,238 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family

1990 • 1,140 citations

Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF

1991 • 1,049 citations

PLATELET-DERIVED GROWTH FACTOR

1989 • 967 citations

Expression and structure of the human NGF receptor

1986 • 956 citations

Gene transfer and molecular cloning of the rat nerve growth factor receptor

1987 • 946 citations

The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3

1991 • 940 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

Murine Sarcoma and Leukemia Viruses: Assay Using Clonal Lines of Contact-Inhibited Mouse Cells

1969 • 821 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor

1990 • 720 citations

The nerve growth factor: thirty-five years later.

1987 • 720 citations

Nerve growth factor receptors. Characterization of two distinct classes of binding sites on chick embryo sensory ganglia cells.

1979 • 627 citations

trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.

1989 • 604 citations

Molecular and biochemical characterization of the human trk proto-oncogene.

1989 • 600 citations

Primary structure and biological activity of a novel human neurotrophic factor

1990 • 553 citations

Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines

1985 • 478 citations

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1985 • 458 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

Molecular cloning of a human gene that is a member of the nerve growth factor family.

1990 • 397 citations

Nerve growth factor induces growth and differentiation of human B lymphocytes.

1989 • 386 citations

Induction of the proto-oncogene fos by nerve growth factor.

1985 • 359 citations

Mast cells increase in tissues of neonatal rats injected with the nerve growth factor

1977 • 357 citations

Polypeptide Growth Factors: Roles In Normal And Abnormal Cell Growth

1987 • 339 citations

Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

1990 • 312 citations

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations.

1991 • 309 citations

Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene

1985 • 306 citations

Evidence that biological activity of NGF is mediated through a novel subclass of high affinity receptors

1991 • 296 citations

PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.

1986 • 282 citations

Kirsten murine sarcoma virus transformed cell lines and a spontaneously transformed rat cell‐line produce transforming factors

1980 • 244 citations

Expression of Functional Nerve Growth Factor Receptors After Gene Transfer

1989 • 235 citations

Molecular characteristics of nerve growth factor receptors on PC12 cells.

1985 • 200 citations

Nerve growth factor is a mitogen for cultured chromaffin cells

1985 • 192 citations

Structure and developmental expression of the nerve growth factor receptor in the chicken central nervous system

1989 • 171 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

PLATELET-DERIVED GROWTH FACTOR

1987 • 136 citations

Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling.

1981 • 133 citations

trkB, a Neural Receptor Protein-Tyrosine Kinase: Evidence for a Full-Length and Two Truncated Receptors

1991 • 131 citations

Molecular and Biochemical Characterization of the Human trk Proto-Oncogene

1989 • 124 citations

Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation

1991 • 116 citations

Nerve growth factor has both mitogenic and antimitogenic activity

1982 • 103 citations

Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding.

1990 • 94 citations

Human trk Oncogenes Activated by Point Mutation, In-Frame Deletion, and Duplication of the Tyrosine Kinase Domain

1990 • 73 citations

Nerve Growth Factor (NGF) Induces Neuronal Differentiation in Neuroblastoma Cells Transfected with the NGF Receptor cDNA

1990 • 72 citations

Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation.

1990 • 71 citations

Nerve growth factor and serum differentially regulate development of the embryonic otic vesicle and cochleovestibular ganglion in vitro

1989 • 61 citations

Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain.

1990 • 54 citations

Nerve growth factor (NGF) induces neuronal differentiation in neuroblastoma cells transfected with the NGF receptor cDNA.

1990 • 48 citations

Regional expression of the nerve growth factor gene family in rat brain during development

1991 • 39 citations

Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences.

1988 • 37 citations

Nerve Growth Factor (NGF) receptors in the central nervous system

1987 • 37 citations

Molecular Analysis of the Nerve Growth Factor Receptor

1988 • 23 citations