NGF-induction of the metalloproteinase-transin/stromelysin in PC12 cells: involvement of multiple protein kinases.

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins

1989 • 3,219 citations

The Nerve Growth Factor 35 Years Later

1987 • 3,107 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

1990 • 2,392 citations

Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

1979 • 2,285 citations

Metalloproteinases and their inhibitors in matrix remodeling

1990 • 1,627 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities

1988 • 1,084 citations

pl Bl5: A cDNA Clone of the Rat mRNA Encoding Cyclophilin

1988 • 1,039 citations

Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells.

1985 • 888 citations

The role of the leucine zipper in the fos–jun interaction

1988 • 836 citations

Inhibition of membrane phosphotyrosyl-protein phosphatase activity by vanadate

1982 • 699 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro.

1988 • 511 citations

Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction.

1989 • 502 citations

Superinduction of c- fos by Nerve Growth Factor in the Presence of Peripherally Active Benzodiazepines

1985 • 478 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

PRIMARY CULTURES OF DISSOCIATED SYMPATHETIC NEURONS

1973 • 426 citations

Induction of the proto-oncogene fos by nerve growth factor.

1985 • 359 citations

Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts.

1985 • 344 citations

Isolation of the oncogene and epidermal growth factor-induced transin gene: complex control in rat fibroblasts.

1986 • 339 citations

K-252a: a specific inhibitor of the action of nerve growth factor on PC 12 cells

1988 • 320 citations

Growth Factors Regulate Transin Gene Expression by c- fos -Dependent and c- fos -Independent Pathways

1988 • 290 citations

Identification and characterization of mRNAs regulated by nerve growth factor in PC12 cells.

1987 • 267 citations

Nerve growth factor regulates tyrosine hydroxylase gene transcription through a nucleoprotein complex that contains c-Fos.

1990 • 247 citations

2-Aminopurine Selectively Inhibits the Induction of β-Interferon, c- fos , and c- myc Gene Expression

1988 • 233 citations

Release of plasminogen activator and a calcium-dependent metalloprotease from cultured sympathetic and sensory neurons

1985 • 221 citations

Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cells.

1986 • 220 citations

Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells

1989 • 219 citations

Down regulation of protein kinase C in neuronal cells: effects on neurotransmitter release

1987 • 204 citations

Protein kinase C as a component of a nerve growth factor-sensitive phosphorylation system in PC12 cells.

1986 • 197 citations

Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2.

1990 • 196 citations

Identification of a Cyclic Adenosine Monophosphate-Responsive Element in the Rat Corticotropin-Releasing Hormone Gene

1988 • 187 citations

Dual regulation of GAP-43 gene expression by nerve growth factor and glucocorticoids.

1988 • 181 citations

Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.

1988 • 172 citations

Epidermal Growth Factor Stimulation of Stromelysin mRNA in Rat Fibroblasts Requires Induction of Proto-Oncogenes c-fos and c-jun and Activation of Protein Kinase C

1990 • 170 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Transcriptional and post-transcriptional effects of nerve growth factor on expression of the three neurofilament subunits in PC-12 cells.

1988 • 153 citations

The induction of a neural-specific gene, SCG10, by nerve growth factor in PC12 cells is transcriptional, protein synthesis dependent, and glucocorticoid inhibitable

1988 • 148 citations

NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells

1989 • 140 citations

Protein kinase C is involved in laminin stimulation of neurite outgrowth

1989 • 140 citations

Nerve Growth Factor Induces the Proto-oncogene c-jun in PC12 Cells

1989 • 134 citations

Nerve growth factor and fibroblast growth factor regulate neurite outgrowth and gene expression in PC12 cells via both protein kinase C- and cAMP-independent mechanisms.

1990 • 121 citations

Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells

1990 • 120 citations

Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C

1987 • 117 citations

Clonal variants of PC12 pheochromocytoma cells with defects in cAMP-dependent protein kinases induce ornithine decarboxylase in response to nerve growth factor but not to adenosine agonists.

1985 • 113 citations

Induction of transiently expressed genes in PC-12 pheochromocytoma cells.

1987 • 109 citations

The mode of action of nerve growth factor in PC12 cells

1988 • 102 citations

Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase.

1989 • 101 citations

Transcriptional and post-transcriptional regulation of tyrosine hydroxylase gene by protein kinase C.

1990 • 100 citations

Isolation of the Oncogene and Epidermal Growth Factor-Induced Transin Gene: Complex Control in Rat Fibroblasts

1986 • 90 citations

Cell-free detection and characterization of a novel nerve growth factor-activated protein kinase in PC12 cells.

1987 • 88 citations

Regulation of protein kinase activities in PC12 pheochromocytoma cells.

1986 • 88 citations

Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine

1990 • 86 citations

Factors influencing GAP-43 gene expression in PC12 pheochromocytoma cells

1990 • 85 citations

The Lack of a Role for Protein Kinase C in Neurite Extension and in the Induction of Ornithine Decarboxylase by Nerve Growth Factor in PC12 Cells

1989 • 78 citations

K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells

1989 • 71 citations

Comparison of the effects of NGF, activators of protein kinase C, and a calcium ionophore on the expression of Thy-1 and N-CAM in PC12 cell cultures.

1988 • 69 citations

Mimicry and Inhibition of Nerve Growth Factor Effects: Interactions of Staurosporine, Forskolin, and K252a in PC12 Cells and Normal Rat Chromaffin Cells In Vitro

1990 • 67 citations

Identification and Characterization of mRnas Regulated by Nerve Growth Factor in PC12 Cells

1987 • 67 citations

Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes

1989 • 57 citations

Blockage of Nerve Growth Factor Action in PC12h Cells by Staurosporine, a Potent Protein Kinase Inhibitor

1989 • 55 citations

The Induction of Ornithine Decarboxylase by Nerve Growth Factor and Epidermal Growth Factor in PC 12 Cells

1981 • 54 citations

Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor beta.

1988 • 49 citations

Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor.

1987 • 47 citations

Effect of nerve growth factor and fibroblast growth factor on SCG10 and c-fos expression and neurite outgrowth in protein kinase C-depleted PC12 cells.

1990 • 47 citations

Characterization of a Nerve Growth Factor‐Stimulated Protein Kinase in PC12 Cells Which Phosphorylates Microtubule‐Associated Protein 2 and pp250

1990 • 43 citations

A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression.

1991 • 42 citations

Effects of 12‐0‐tetradecanoylphorbol‐13‐acetate (TPA) on rat pheochromocytoma (PC12) cells: Interactions with epidermal growth factor and nerve growth factor

1982 • 39 citations

Epidermal growth factor receptor expression during morphological differentiation of pheochromocytoma cells, induced by nerve growth factor or dibutyryl cyclic AMP

1987 • 38 citations

Nerve Growth Factor‐Induced Down‐Regulation of Calmodulin‐Dependent Protein Kinase III in PC12 Cells Involves Cyclic AMP‐Dependent Protein Kinase

1990 • 37 citations

Role of the cAMP‐dependent protein kinase and protein kinase C in regulating the morphological differentiation of PC12 cells

1990 • 36 citations

A Nerve Growth Factor‐Sensitive S6 Kinase in Cell‐Free Extracts from PC 12 Cells

1986 • 29 citations

Increased Intracellular Cyclic AMP Differentially Modulates Nerve Growth Factor Induction of Three Neuronal Recognition Molecules Involved in Neurite Outgrowth

1989 • 29 citations

Clonal Variants of PC12 Pheochromocytoma Cells with Defects in cAMP-Dependent Protein Kinases Induce Ornithine Decarboxylase in Response to Nerve Growth Factor but not to Adenosine Agonists

1985 • 27 citations

Protein kinase C negatively modulated by phorbol ester

1986 • 25 citations

Detection of Phosphotyrosine-Containing Proteins in Polyomavirus Middle Tumor Antigen-Transformed Cells After Treatment with a Phosphotyrosine Phosphatase Inhibitor

1987 • 25 citations

Transcriptional Modulation of Transin Gene Expression by Epidermal Growth Factor and Transforming Growth Factor Beta

1988 • 12 citations

Gene Regulation by Nerve Growth Factor

1985 • 4 citations