ras isoprenylation is required for ras-induced but not for NGF-induced neuronal differentiation of PC12 cells.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Quantitative Film Detection of 3H and 14C in Polyacrylamide Gels by Fluorography

1975 • 4,693 citations

ras GENES

1987 • 3,818 citations

Oncogenes and signal transduction

1991 • 2,816 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

The Cellular Functions of Small GTP-Binding Proteins

1990 • 881 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation

1985 • 738 citations

Characterization and isolation of proteolytically modified nerve growth factor

1976 • 677 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell line

1985 • 458 citations

Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium

1978 • 431 citations

Inhibition of growth factor-induced differentiation of PC12 cells by microinjection of antibody to ras p21

1986 • 421 citations

Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry

1980 • 404 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Farnesylated γ-subunit of photoreceptor G protein indispensable for GTP-binding

1990 • 389 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Nerve growth factor mediates phosphorylation of specific proteins

1980 • 305 citations

PC12 cell mutants that possess low- but not high-affinity nerve growth factor receptors neither respond to nor internalize nerve growth factor.

1986 • 282 citations

Evidence for modification of lamin B by a product of mevalonic acid.

1988 • 254 citations

Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells.

1981 • 239 citations

Structural and functional properties of ras proteins

1989 • 211 citations

Nerve growth factor induces protein-tyrosine phosphorylation.

1988 • 184 citations

Nerve growth factor action is mediated by cyclic AMP- and Ca+2/phospholipid-dependent protein kinases.

1986 • 169 citations

Direct identification of palmitic acid as the lipid attached to p21ras.

1986 • 157 citations

Activated N‐ras gene induces neuronal differentiation of PC12 rat pheochromocytoma cells

1986 • 149 citations

Rapid, sequential changes in surface morphology of PC12 pheochromocytoma cells in response to nerve growth factor

1979 • 146 citations

Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

1987 • 136 citations

Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1985 • 129 citations

Nerve growth factor and other agents mediate phosphorylation and activation of tyrosine hydroxylase. A convergence of multiple kinase activities.

1985 • 124 citations

Common Modifications of Trimeric G Proteins and ras Protein: Involvement of Polyisoprenylation

1990 • 122 citations

K-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells.

1988 • 115 citations

Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP.

1984 • 112 citations

Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid.

1990 • 103 citations

Nerve growth factor has both mitogenic and antimitogenic activity

1982 • 103 citations

Differential inhibition of nerve growth factor and epidermal growth factor effects on the PC12 pheochromocytoma line.

1984 • 102 citations

Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase.

1989 • 101 citations

Isoprenylation of C-terminal cysteine in a G-protein gamma subunit.

1990 • 95 citations

Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability

1989 • 89 citations

Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis

1985 • 87 citations

Dissociation of c-fos from ODC expression and neuronal differentiation in a PC12 subline stably transfected with an inducible N-ras oncogene

1988 • 70 citations

Evidence for an S-farnesylcysteine methyl ester at the carboxyl terminus of the Saccharomyces cerevisiae RAS2 protein

1990 • 63 citations

Purine analogs inhibit nerve growth factor-promoted neurite outgrowth by sympathetic and sensory neurons

1990 • 58 citations

Effect of a Dominant Inhibitory Ha-ras Mutation on Neuronal Differentiation of PC12 Cells

1990 • 58 citations

Differentiation of PC12 cells with v‐src: Comparison with nerve growth factor

1989 • 55 citations

Role of protein tyrosine phosphorylation in the NGF response

1989 • 52 citations

Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae.

1989 • 51 citations

Effect of nerve growth factor and fibroblast growth factor on SCG10 and c-fos expression and neurite outgrowth in protein kinase C-depleted PC12 cells.

1990 • 47 citations

Direct Identification of Palmitic Acid as the Lipid Attached to p21^ras

1986 • 42 citations

Induction of differentiation in murine neuroblastoma cells by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

1984 • 36 citations

Decreased levels of nerve growth factor receptor on dexamethasone‐treated PC12 cells

1988 • 32 citations

Oncogene N-ras mediates selective inhibition of c-fos induction by nerve growth factor and basic fibroblast growth factor in a PC12 cell line.

1990 • 23 citations

Potentiation of oncogenic N‐ras‐induced neurite outgrowth and ornithine decarboxylase activity by phorbol dibutyrate and protein kinase inhibitor H‐8

1990 • 8 citations

Oncogene N-rasMediates Selective Inhibition of c-fosInduction by Nerve Growth Factor and Basic Fibroblast Growth Factor in a PC12 Cell Line

1990 • 7 citations