Spinning molecular immunology into successful immunotherapy

Dendritic cells and the control of immunity

1998 • 14,345 citations

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 • 4,853 citations

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1990 • 3,896 citations

A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma

1991 • 3,493 citations

Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells

1998 • 2,916 citations

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 • 2,746 citations

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

1999 • 2,380 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

High-Dose Recombinant Interleukin 2 Therapy for Patients With Metastatic Melanoma: Analysis of 270 Patients Treated Between 1985 and 1993

1999 • 1,967 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine

2000 • 1,594 citations

Activation of human dendritic cells through CD40 cross-linking.

1994 • 1,351 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharynx

1970 • 1,261 citations

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.

1989 • 1,186 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

1995 • 1,147 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

CD91 Is a Common Receptor for Heat Shock Proteins gp96, hsp90, hsp70, and Calreticulin

2001 • 1,118 citations

Human neoplasms elicit multiple specific immune responses in the autologous host.

1995 • 1,097 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Roles of heat-shock proteins in innate and adaptive immunity

2002 • 1,037 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

1996 • 992 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

Detection of Epstein–Barr Viral Genomes in Reed–Sternberg Cells of Hodgkin's Disease

1989 • 917 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

2001 • 850 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Immunotherapy of Tumors with Autologous Tumor-Derived Heat Shock Protein Preparations

1997 • 699 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Immunotherapy of Hormone-Refractory Prostate Cancer With Antigen-Loaded Dendritic Cells

2000 • 627 citations

Identification of human cancers deficient in antigen processing.

1993 • 625 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells

1997 • 596 citations

Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

1978 • 588 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

Novel Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Tumor Vaccine for Pancreatic Cancer: A Phase I Trial of Safety and Immune Activation

2001 • 576 citations

Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp100 modified at HLA-A*0201-binding residues.

1996 • 566 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

2001 • 555 citations

The Dendritic Cell Receptor for Endocytosis, Dec-205, Can Recycle and Enhance Antigen Presentation via Major Histocompatibility Complex Class II–Positive Lysosomal Compartments

2000 • 546 citations

Genetically engineered poxviruses for recombinant gene expression, vaccination, and safety.

1996 • 521 citations

Identification of proliferating dendritic cell precursors in mouse blood.

1992 • 445 citations

Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.

2000 • 421 citations

Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by Ex Vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer

1998 • 419 citations

Receptor-Mediated Uptake of Antigen/Heat Shock Protein Complexes Results in Major Histocompatibility Complex Class I Antigen Presentation via Two Distinct Processing Pathways

1999 • 413 citations

Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, hsp90, and hsp70.

1994 • 411 citations

Oral Somatic Transgene Vaccination Using Attenuated S. typhimurium

1997 • 409 citations

A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.

1990 • 409 citations

B cells inhibit induction of T cell-dependent tumor immunity

1998 • 393 citations

Dendritic Cells Genetically Modified with an Adenovirus Vector Encoding the cDNA for a Model Antigen Induce Protective and Therapeutic Antitumor Immunity

1997 • 390 citations

Engagement of the OX-40 Receptor In Vivo Enhances Antitumor Immunity

2000 • 386 citations

Vaccination with a recombinant vaccinia virus encoding a “self” antigen induces autoimmune vitiligo and tumor cell destruction in mice: Requirement for CD4⁺T lymphocytes

1999 • 383 citations

CTLA-4 blockade synergizes with tumor-derived granulocyte– macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma

1998 • 375 citations

The prime-boost strategy: exciting prospects for improved vaccination

2000 • 373 citations

Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes.

1995 • 372 citations

Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation

1984 • 359 citations

Enhancement of DNA vaccine potency by linkage of antigen gene to an HSP70 gene.

2000 • 354 citations

Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens.

1995 • 343 citations

Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

1995 • 339 citations

Vitiligo in Patients with Melanoma

1996 • 335 citations

Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor

2001 • 322 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma

1993 • 314 citations

Enhanced Antigen-Specific Antitumor Immunity with Altered Peptide Ligands that Stabilize the MHC-Peptide-TCR Complex

2000 • 312 citations

Dendritic Cells Retrovirally Transduced with a Model Antigen Gene Are Therapeutically Effective against Established Pulmonary Metastases

1997 • 309 citations

Generation of Mature Dendritic Cells from Human Blood

1997 • 297 citations

Construction and characterization of an infectious vaccinia virus recombinant that expresses the influenza hemagglutinin gene and induces resistance to influenza virus infection in hamsters.

1983 • 296 citations

Attenuated Shigella as a DNA Delivery Vehicle for DNA-Mediated Immunization

1995 • 292 citations

Cancer Tumor antigens

1997 • 289 citations

Detection of ebv gene expression in reed‐sternberg cells of Hodgkin's disease

1990 • 279 citations

Negative regulation of cytokine signaling

2001 • 259 citations

A Monocyte Conditioned Medium Is More Effective Than Defined Cytokines in Mediating the Terminal Maturation of Human Dendritic Cells

1997 • 256 citations

Heat shock fusion proteins as vehicles for antigen delivery into the major histocompatibility complex class I presentation pathway

1997 • 253 citations

Enhanced responses to a DNA vaccine encoding a fusion antigen that is directed to sites of immune induction

1998 • 251 citations

SSX: A multigene family with several members transcribed in normal testis and human cancer

1997 • 242 citations

A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours

1995 • 237 citations

Signaling through OX40 (CD134) breaks peripheral T-cell tolerance

2001 • 235 citations

Cabin 1, A Negative Regulator for Calcineurin Signaling in T Lymphocytes

1998 • 235 citations

Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response.

1996 • 232 citations

Engineering of in vivo immune responses to DNA immunization via codelivery of costimulatory molecule genes

1997 • 226 citations

Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin.

1983 • 225 citations

Human tumor antigens recognized by T cells

1996 • 217 citations

The role of heat shock protein (hsp70) in dendritic cell maturation: Hsp70 induces the maturation of immature dendritic cells but reduces DC differentiation from monocyte precursors

2001 • 208 citations

Targeting Human Papillomavirus Type 16 E7 to the Endosomal/Lysosomal Compartment Enhances the Antitumor Immunity of DNA Vaccines against Murine Human Papillomavirus Type 16 E7-Expressing Tumors

1999 • 207 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

Heteroclitic Immunization Induces Tumor Immunity

1998 • 203 citations

Human CD14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4

1996 • 199 citations

Dendritic Cells Infiltrating Tumors Cotransduced with Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf) and Cd40 Ligand Genes Take up and Present Endogenous Tumor-Associated Antigens, and Prime Naive Mice for a Cytotoxic T Lymphocyte Response

1999 • 184 citations

Peripheral T cell tolerance as a tumor escape mechanism: deletion of CD4⁺ T cells specific for a monoclonal immunoglobulin idiotype secreted by a plasmacytoma

1996 • 165 citations

Characterization of Heat Shock Protein 110 and Glucose-Regulated Protein 170 as Cancer Vaccines and the Effect of Fever-Range Hyperthermia on Vaccine Activity

2001 • 165 citations

Cytokine-in-adjuvant steering of the immune response phenotype to HIV-1 vaccine constructs: granulocyte-macrophage colony-stimulating factor and TNF-alpha synergize with IL-12 to enhance induction of cytotoxic T lymphocytes.

1997 • 161 citations

Enhancing Efficacy of Recombinant Anticancer Vaccines With Prime/Boost Regimens That Use Two Different Vectors

1997 • 158 citations

Comparative Analysis of Genetically Modified Dendritic Cells and Tumor Cells as Therapeutic Cancer Vaccines

2000 • 158 citations

Optimization of epitope processing enhances immunogenicity of multiepitope DNA vaccines

2001 • 155 citations

Cancer immunotherapy using a DNA vaccine encoding the translocation domain of a bacterial toxin linked to a tumor antigen.

2001 • 154 citations

Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

1996 • 147 citations

Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes

2001 • 145 citations

Improving Vaccine Potency Through Intercellular Spreading and Enhanced MHC Class I Presentation of Antigen

2001 • 139 citations

Principles and Practice of the Biologic Therapy of Cancer

2000 • 134 citations

Eradication of established tumors by vaccination with Venezuelan equine encephalitis virus replicon particles delivering human papillomavirus 16 E7 RNA.

2001 • 130 citations

Targeting dendritic cells to enhance DNA vaccine potency.

2001 • 115 citations

Recent advances with recombinant bacterial vaccine vectors

2000 • 114 citations

Enhancement of tumor lysate- and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein.

2001 • 113 citations

Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a Murine tumor model

1997 • 110 citations

ANTIGENIC SPECIFICITIES ON MURINE SARCOMA CELLS

1971 • 107 citations

The T-cell protein tyrosine phosphatase

2000 • 107 citations

Immunocytokines

1998 • 99 citations

Recombinant BCG vaccines

2001 • 92 citations

Highly Attenuated Poxvirus Vectors

1992 • 89 citations

p21‐ras‐peptide‐specific T‐cell responses in a patient with colorectal cancer. CD4⁺ and CD8⁺ T cells recognize a peptide corresponding to a common mutation (13Gly → Asp)

1994 • 85 citations

Immunization with type 5 adenovirus recombinant for a tumor antigen in combination with recombinant canarypox virus (alvac) cytokine gene delivery induces destruction of established prostate tumors

2001 • 84 citations

CD86 (B7-2) Can Function to Drive MHC-Restricted Antigen-Specific CTL Responses In Vivo

1999 • 76 citations

Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis.

2001 • 69 citations

Loss of HLA class‐I alleles, heavy chains and β₂‐microglobulin in colorectal cancer

1992 • 61 citations

Virus subversion of immunity: a structural perspective

2001 • 53 citations

Highly attenuated poxvirus vectors: NYVAC, ALVAC and TROVAC.

1995 • 40 citations

Characterization of the humoral immune response to genital papillomaviruses.

1990 • 39 citations

Live bacterial delivery systems for development of mucosal vaccines.

2000 • 38 citations

A K‐ras 13GLY → ASP mutation is recognized by HLA‐DQ7 restricted T cells in a patient with colorectal cancer. Modifying effect of DQ7 on established cancers harbouring this mutation?

1994 • 38 citations

Equipotent Generation of Protective Antitumor Immunity by Various Methods of Dendritic Cell Loading With Whole Cell Tumor Antigens

2001 • 36 citations

Lack of expression of HLA-ABC antigens in choriocarcinoma and other human tumor cell lines.

1982 • 35 citations

Bacterial Mucosal Vaccines: Vibrio cholerae as a Live Attenuated Vaccine/Vector Paradigm

1999 • 22 citations

T‐Cell Recognition of Antigen

1995 • 12 citations

[What is the role of hepatitis B virus in the appearance of hepatocellular carcinomas in patients with alcoholic cirrhosis?].

1982 • 2 citations