Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

Heritable formation of pancreatic β-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes

1985 • 1,292 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

Tumor Antigens Recognized by T Lymphocytes

1994 • 1,238 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Tumor Rejection After Direct Costimulation of CD8 ⁺ T Cells by B7-Transfected Melanoma Cells

1993 • 1,154 citations

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

1992 • 1,076 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.

1994 • 921 citations

Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo

1984 • 884 citations

Implications for immunosurveillance of altered HLA class I phenotypes in human tumours

1997 • 769 citations

Antigenicity of Murine Skin Tumors Induced by Ultraviolet Light2

1974 • 484 citations

Lymphocytic Choriomeningitis Virus

2016 • 423 citations

Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas.

1994 • 333 citations

How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model

1994 • 309 citations

Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs

1995 • 308 citations

Vitiligo in patients with metastatic melanoma: A good prognostic sign

1983 • 292 citations

Antigenic Properties of Lymphomas Induced by the Moloney Agent<xref ref-type="fn" rid="FN2">2</xref>

1964 • 286 citations

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic β cells

1987 • 269 citations

Genes Coding for Tumor Antigens Recognized by Cytolytic T Lymphocytes

1995 • 233 citations

Antibodies to normal human melanocytes in vitiligo.

1983 • 221 citations

Induction of anti-self-immunity to cure cancer

1995 • 207 citations

The role of tyrosinase in autoimmune vitiligo

1994 • 198 citations

Implicating a role for immune recognition of self in tumor rejection: passive immunization against the brown locus protein.

1995 • 186 citations

Interactions between SV40 large‐tumor antigen and the growth suppressor proteins pRB and p53

1993 • 180 citations

Rejection by syngeneic mice of cell variants obtained by mutagenesis of a malignant teratocarcinoma cell line.

1977 • 147 citations

Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo?

1996 • 147 citations

Lymphocytic Choriomeningitis Virus

1971 • 143 citations

Vaccination and protection from a lethal viral infection: Identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope

1990 • 132 citations

Tumor immunotherapy: the tumor cell as an antigen-presenting cell

1994 • 132 citations

CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells.

1995 • 124 citations

Limited capacity for tolerization of CD4+ T cells specific for a pancreatic β cell neo-antigen

1995 • 121 citations

T‐Cell Immunotherapy of Tumors by Adoptive Transfer of Cytotoxic T Lymphocytes and by Vaccination with Minimal Essential Epitopes

1995 • 115 citations

Modulation of L-selectin ligand expression during an immune response accompanying tumorigenesis in transgenic mice.

1996 • 101 citations

T and B cell Tolerance and Responses to Viral Antigens in Transgenic Mice: Implications for the Pathogenesis of Autoimmune versus Immunopathological Disease

1991 • 97 citations

Teratocarcinoma cell variants rejected by syngeneic mice: protection of mice immunized with these variants against other variants and against the original malignant cell line.

1978 • 88 citations

Cell-Surface Differentiation in the Mouse

1980 • 86 citations

Can Co‐stimulated Tumor Immunity be Therapeutically Efficacious?

1995 • 81 citations

Timely immunization subverts the development of peripheral nonresponsiveness and suppresses tumor development in simian virus 40 tumor antigen-transgenic mice.

1994 • 74 citations

The immune response of the mouse to lymphocytic choriomeningitis virus V. High numbers of cytolytic T lymphocytes are generated in the spleen during acute infection

1987 • 72 citations

An evaluation of the potential to use tumor-associated antigens as targets for antitumor T cell therapy using transgenic mice expressing a retroviral tumor antigen in normal lymphoid tissues.

1993 • 69 citations

The immune response of the mouse to lymphocytic choriomeningitis virus

1983 • 64 citations

Direct analysis of tumor-associated peptide antigens

1994 • 60 citations

Neoplastic cells that express low levels of MHC class I determinants escape host immunity.

1994 • 47 citations

Functional analysis of the retinoblastoma gene product and of RB-SV40 T antigen complexes.

1992 • 14 citations