Generation of Mature Dendritic Cells from Human Blood

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

1996 • 2,032 citations

Proliferating dendritic cell progenitors in human blood.

1994 • 1,922 citations

Vaccination of patients with B–cell lymphoma using autologous antigen–pulsed dendritic cells

1996 • 1,854 citations

GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells

1992 • 1,608 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

CD14+ blood monocytes can differentiate into functionally mature CD83+ dendritic cells.

1996 • 1,105 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily.

1995 • 756 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Interleukin‐10 differentially regulates B7‐1 (CD80) and B7‐2 (CD86) expression on human peripheral blood dendritic cells

1995 • 282 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

Disappearance of certain acidic organelles (endosomes and Langerhans cell granules) accompanies loss of antigen processing capacity upon culture of epidermal Langerhans cells.

1990 • 159 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

Interleukin‐10 inhibits the primary allogeneic T cell response to human epidermal Langerhans cells

1994 • 151 citations

Human Cutaneous Dendritic Cells Migrate Through Dermal Lymphatic Vessels in a Skin Organ Culture Model

1996 • 114 citations

Interleukin-10 production in malignant melanoma: Preferential detection of IL-10-secreting tumor cells in metastatic lesions

1996 • 105 citations

Both Dendritic Cells and Memory T Lymphocytes Emigrate From Organ Cultures of Human Skin and Form Distinctive Dendritic-T-Cell Conjugates

1995 • 95 citations

Human Resident Langerhans Cells Display a Lysosomal compartment Enriched in MHC Class II

1994 • 68 citations

Dendritic antigen-presenting cells from the peripheral blood of renal-cell-carcinoma patients

1995 • 43 citations

Biochemical properties of MHC class II molecules endogenously synthesized and expressed by mouse Langerhans cells

1991 • 42 citations