Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen.

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

IgG or IgM monoclonal antibodies reactive with different determinants on the molecular complex bearing Lyt 2 antigen block T cell-mediated cytolysis in the absence of complement.

1980 • 835 citations

Treatment of Established Renal Cancer by Tumor Cells Engineered to Secrete Interleukin-4

1991 • 733 citations

Human papillomavirus type 16 DNA sequence

1985 • 718 citations

The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells

1991 • 592 citations

Immunology: The ins and outs of antigen processing and presentations

1986 • 498 citations

Identification of two lysosomal membrane glycoproteins.

1985 • 475 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

Follicular Dendritic Cells as Accessory Cells

1990 • 351 citations

Role for intracellular proteases in the processing and transport of class II HLA antigens.

1988 • 336 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Glycoproteins of the lysosomal membrane.

1985 • 294 citations

Human CD4+ T cells specifically recognize a shared melanoma-associated antigen encoded by the tyrosinase gene.

1994 • 287 citations

T and B memory cells

1994 • 285 citations

Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail.

1990 • 272 citations

The binary logic of antigen processing and presentation to T cells

1990 • 235 citations

In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.

1994 • 196 citations

The motif Tyr-X-X-hydrophobic residue mediates lysosomal membrane targeting of lysosome-associated membrane protein 1.

1993 • 169 citations

The NK-1.1(-) mouse: a model to study differentiation of murine NK cells.

1986 • 165 citations

Immunization against human papillomavirus type 16 tumor cells with recombinant vaccinia viruses expressing E6 and E7

1991 • 160 citations

Melanoma‐specific CD4+ T lymphocytes recognize human melanoma antigens processed and presented by epstein‐barr virus‐transformed B cells

1994 • 86 citations

Immunology of the human papilloma virus in relation to cancer

1994 • 77 citations

The effect of class II gene transfection on the tumourigenicity of the H-2K-negative mouse leukaemia cell line K36.16.

1991 • 46 citations

Rejection of K1735 murine melanoma in syngeneic hosts requires expression of MHC class I antigens and either class II antigens or IL-2.

1993 • 42 citations