Oral Somatic Transgene Vaccination Using Attenuated S. typhimurium

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Studies on transformation of Escherichia coli with plasmids

1983 • 11,179 citations

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

DNA VACCINES

1997 • 977 citations

DNA–based immunization by in vivo transfection of dendritic cells

1996 • 849 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Systemic Gene Expression After Intravenous DNA Delivery into Adult Mice

1993 • 725 citations

The JAM test A simple assay for DNA fragmentation and cell death

1991 • 632 citations

Isolation and Characterization of Gal E Mutant Ty 21a of Salmonella typhi: A Candidate Strain for a Live, Oral Typhoid Vaccine

1975 • 521 citations

Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines

1995 • 486 citations

Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN [correction of INF] and augment IFN-mediated [correction of INF] natural killer activity.

1992 • 480 citations

ANTIGEN SAMPLING ACROSS EPITHELIAL BARRIERS AND INDUCTION OF MUCOSAL IMMUNE RESPONSES

1996 • 462 citations

Precise prediction of a dominant class I MHC-restricted epitope of Listeria monocytogenes

1991 • 425 citations

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

1995 • 416 citations

A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to the proline-rich region of vinculin.

1992 • 411 citations

Coordinate regulation of virulence genes in Listeria monocytogenes requires the product of the prfA gene

1992 • 404 citations

Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA.

1991 • 378 citations

In vivo engineering of a cellular immune response by co-administration of IL-12 expression vector with a DNA immunogen

1997 • 347 citations

Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis.

1995 • 300 citations

Attenuated Shigella as a DNA Delivery Vehicle for DNA-Mediated Immunization

1995 • 292 citations

In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen.

1997 • 286 citations

Expression in Escherichia coli and sequence analysis of the listeriolysin O determinant of Listeria monocytogenes

1988 • 286 citations

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes–prone mice

1996 • 266 citations

CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.

1992 • 260 citations

Immune Response to Cholera Toxin Epitope Inserted in Salmonella Flagellin

1989 • 257 citations

Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids.

1997 • 257 citations

Superior efficacy of secreted over somatic antigen display in recombinant Salmonella vaccine induced protection against listeriosis.

1996 • 219 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

M cells and the pathogenesis of mucosal and systemic infections

1996 • 168 citations

An Attenuated aroA Salmonella typhimurium Vaccine Elicits Humoral and Cellular Immunity to Cloned -Galactosidase in Mice

1987 • 131 citations

High efficiency transformation of Salmonella typhimurium and Salmonella typhi by electroporation

1990 • 120 citations

[54] Embryonic stem cell differentiation in vitro

1993 • 116 citations

Effect of vaccination of hens with an avirulent strain of Salmonella typhimurium on immunity of progeny challenged with wild-Type Salmonella strains

1996 • 101 citations

Generation of a cytotoxic T‐lymphocyte response using a Salmonella antigen‐delivery system

1990 • 101 citations

Gene transfer from bacteria to mammalian cells.

1995 • 91 citations

Protein-specific cytotoxic T lymphocytes. Recognition of transfectants expressing intracellular, membrane-associated or secreted forms of β-galactosidase

1989 • 59 citations

Salmonella typhimurium delta aroA delta aroD mutants expressing a foreign recombinant protein induce specific major histocompatibility complex class I-restricted cytotoxic T lymphocytes in mice

1993 • 57 citations

Upstream binding sequences of the XyIR activator protein and integration host factor in thexylSgene promoter region of thePseudomonasTOL plasmid

1992 • 51 citations

Hyperexpression of listeriolysin in the nonpathogenic species Listeria innocua and high yield purification

1995 • 50 citations

Listeriolysin generates a route for the presentation of exogenous antigens by major histocompatibility complex class I

1995 • 47 citations

Specific lung mucosal and systemic immune responses after oral immunization of mice with Salmonella typhimurium aroA, Salmonella typhi Ty21a, and invasive Escherichia coli expressing recombinant pertussis toxin S1 subunit

1992 • 47 citations

Class II-restricted presentation of a hen egg lysozyme determinant derived from endogenous antigen sequestered in the cytoplasm or endoplasmic reticulum of the antigen presenting cells.

1993 • 45 citations

TAP‐dependent major histocompatibility complex class I presentation of soluble proteins using listeriolysin

1997 • 38 citations

Antibody responses in the lungs of mice following oral immunization with Salmonella typhimurium aroA and invasive Escherichia coli strains expressing the filamentous hemagglutinin of Bordetella pertussis

1991 • 34 citations

Progress in the Development of Multivalent Oral Vaccines Based on Live Attenuated Salmonella

1994 • 22 citations

Use of live attenuated bacteria to stimulate immunity

1990 • 19 citations

Safety and efficacy of an avirulent live Salmonella choleraesuis vaccine for protection of calves against S dublin infection

1997 • 13 citations

Influence of prior infection on the dynamics of bacterial counts in calves experimentally infected with Salmonella dublin

1996 • 13 citations