Lentivirus-transduced human monocyte-derived dendritic cells efficiently stimulate antigen-specific cytotoxic T lymphocytes

Dendritic cells and the control of immunity

1998 • 14,345 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector

1996 • 4,854 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

A Third-Generation Lentivirus Vector with a Conditional Packaging System

1998 • 3,175 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

1997 • 1,977 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

1997 • 1,911 citations

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.

1996 • 1,516 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Generation of mature dendritic cells from human blood An improved method with special regard to clinical applicability

1996 • 1,138 citations

Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo

1999 • 1,013 citations

Integration of murine leukemia virus DNA depends on mitosis.

1993 • 931 citations

A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.

1996 • 925 citations

Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes.

1994 • 850 citations

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

1994 • 845 citations

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1994 • 798 citations

Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector

1997 • 732 citations

Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

1999 • 727 citations

Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood

1996 • 696 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors

1997 • 614 citations

Alu polymerase chain reaction: a method for rapid isolation of human-specific sequences from complex DNA sources.

1989 • 578 citations

Dendritic cell subtypes in mouse lymphoid organs: cross-correlation of surface markers, changes with incubation, and differences among thymus, spleen, and lymph nodes.

1997 • 524 citations

Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector

1997 • 499 citations

Dendritic Cell Vaccines for Cancer Immunotherapy

1999 • 497 citations

Cytotoxic T lymphocytes recognize a fragment of influenza virus matrix protein in association with HLA-A2

1987 • 429 citations

Dendritic cells freshly isolated from human blood express CD4 and mature into typical immunostimulatory dendritic cells after culture in monocyte-conditioned medium.

1993 • 395 citations

Effects of retroviral vector design on expression of human adenosine deaminase in murine bone marrow transplant recipients engrafted with genetically modified cells.

1995 • 357 citations

Immature Dendritic Cells Selectively Replicate Macrophagetropic (M-Tropic) Human Immunodeficiency Virus Type 1, while Mature Cells Efficiently Transmit both M- and T-Tropic Virus to T Cells

1998 • 325 citations

Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells

1987 • 304 citations

Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.

1994 • 276 citations

Dendritic Cells

1999 • 269 citations

Minimal Requirement for a Lentivirus Vector Based on Human Immunodeficiency Virus Type 1

1998 • 263 citations

Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.

1987 • 237 citations

Retroviral transduction of human dendritic cells with a tumor-associated antigen gene.

1996 • 218 citations

Endogenously synthesized peptide with an endoplasmic reticulum signal sequence sensitizes antigen processing mutant cells to class I-restricted cell-mediated lysis.

1991 • 215 citations

The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2.

1991 • 214 citations

Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.

1990 • 210 citations

Cd40-Independent Pathways of T Cell Help for Priming of Cd8+ Cytotoxic T Lymphocytes

2000 • 201 citations

Viral Protein R Regulates Docking of the HIV-1 Preintegration Complex to the Nuclear Pore Complex

1998 • 185 citations

High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells

1998 • 182 citations

Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells

2000 • 180 citations

HIV-1, Vpr and the cell cycle

1996 • 173 citations

Recombinant Retroviruses Pseudotyped With the Vesicular Stomatitis Virus G Glycoprotein Mediate Both Stable Gene Transfer and Pseudotransduction in Human Peripheral Blood Lymphocytes

1997 • 169 citations

Lentiviral Vectors--the Promise of Gene Therapy Within Reach?

1999 • 168 citations

High Efficiency Adenovirus-Mediated Gene Transfer to Human Dendritic Cells

1998 • 167 citations

Identification of Five MAGE-A1 Epitopes Recognized by Cytolytic T Lymphocytes Obtained by In Vitro Stimulation with Dendritic Cells Transduced with MAGE-A1

1999 • 154 citations

Transduction of Human PBMC-Derived Dendritic Cells and Macrophages by an HIV-1-Based Lentiviral Vector System

2000 • 127 citations

Effect of mutations and variations of HLA-A2 on recognition of a virus peptide epitope by cytotoxic T lymphocytes.

1988 • 117 citations

Identification of the nonamer peptide from influenza A matrix protein and the role of pockets of HLA‐A2 in its recognition by cytotoxic T lymphocytes

1992 • 114 citations

Evidence that retroviruses integrate into post-replication host DNA.

1993 • 110 citations

Generation and functional characterization of mouse monocyte-derived dendritic cells

1999 • 93 citations

Retrovirally Transduced Human Dendritic Cells Express a Normal Phenotype and Potent T-Cell Stimulatory Capacity

1997 • 85 citations

Induction of Epstein-Barr Virus-Specific Cytotoxic T-Lymphocyte Responses Using Dendritic Cells Pulsed With EBNA-3A Peptides or UV-Inactivated, Recombinant EBNA-3A Vaccinia Virus

1999 • 78 citations

A Critical Role for Conserved Residues in the Cleft of HLA-A2 in Presentation of a Nonapeptide to T Cells

1992 • 72 citations

Enrichment of an Antigen-Specific T Cell Response by Retrovirally Transduced Human Dendritic Cells

1999 • 71 citations

Retrovirally Transduced Mouse Dendritic Cells Require CD4+ T Cell Help to Elicit Antitumor Immunity: Implications for the Clinical Use of Dendritic Cells

2000 • 71 citations

The internal ribosomal entry site of the encephalomyocarditis virus enables reliable coexpression of two transgenes in human primary T lymphocytes

1997 • 69 citations

Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins

1995 • 65 citations

Active site-directed double mutants of dihydrofolate reductase.

1996 • 61 citations

Efficient Retrovirus-Mediated Gene Transfer of Dendritic Cells Generated from CD34⁺Cord Blood Cells under Serum-Free Conditions

1997 • 46 citations

Analysis of mutant HLA-A2 molecules. Differential effects on peptide binding and CTL recognition.

1994 • 46 citations

Antigen gene transfer to cultured human dendritic cells using recombinant avipoxvirus vectors

1999 • 44 citations

High Level of Retrovirus-Mediated Gene Transfer into Dendritic Cells Derived from Cord Blood and Mobilized Peripheral Blood CD34+ Cells

1999 • 43 citations

Pure populations of transduced primary human cells can be produced using GFP expressing herpes virus vectors and flow cytometry

1998 • 38 citations

Methods for the Construction of Retroviral Vectors and the Generation of High-Titer Producers

2003 • 30 citations

Retroviral Expression of MUC-1 Human Tumor Antigen with Intact Repeat Structure and Capacity to Elicit Immunity In Vivo

1998 • 23 citations

In vitro human cytotoxic T cell responses against influenza A virus can be induced and selected by synthetic peptides

1990 • 19 citations

Expression of the nlsLacz gene in dendritic cells derived from retrovirally transduced peripheral blood CD34+ cells.

1999 • 10 citations

The Movements of Horizontal Pendulums

1895 • 2 citations